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Jenz ST, Goodyear CD, TSgt Graves PR, et al. Blood and affective markers of stress in Elite Airmen during a preparatory training course: A pilot study. Neurobiol Stress. 2021;14:100323doi: 10.1016/j.ynstr.2021.100323.
Jenz, S. T., Goodyear, C. D., TSgt Graves, P. R., Goldstein, S., Shia, M. R., & Redei, E. E. (2021). Blood and affective markers of stress in Elite Airmen during a preparatory training course: A pilot study. Neurobiology of stress, 14100323. https://doi.org/10.1016/j.ynstr.2021.100323
Jenz, S T, et al. "Blood and affective markers of stress in Elite Airmen during a preparatory training course: A pilot study." Neurobiology of stress vol. 14 (2021): 100323. doi: https://doi.org/10.1016/j.ynstr.2021.100323
Jenz ST, Goodyear CD, TSgt Graves PR, Goldstein S, Shia MR, Redei EE. Blood and affective markers of stress in Elite Airmen during a preparatory training course: A pilot study. Neurobiol Stress. 2021 Apr 09;14:100323. doi: 10.1016/j.ynstr.2021.100323. eCollection 2021 May. PMID: 33912629; PMCID: PMC8066699.
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Neurobiol Stress. 2021 Apr 09;14:100323. doi: 10.1016/j.ynstr.2021.100323. eCollection 2021 May.

Blood and affective markers of stress in Elite Airmen during a preparatory training course: A pilot study.

Neurobiology of stress

S T Jenz, C D Goodyear, P R TSgt Graves, S Goldstein, M R Shia, E E Redei

Affiliations

  1. Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
  2. lnfoscitex Corporation, 4027 Colonel Glenn Highway, Suite 210, Dayton, OH, 45431, USA.
  3. Air Force Research Laboratory, 711th Human Performance Wing, Airman Systems Directorate, 2510 Fifth Street, Wright Patterson AFB, OH, 45433, USA.
  4. Air Force Research Laboratory, Materials and Manufacturing Directorate, 2977 Hobson Way, Wright-Patterson AFB, OH, 45433, USA.

PMID: 33912629 PMCID: PMC8066699 DOI: 10.1016/j.ynstr.2021.100323

Abstract

In highly stressful environments, individuals with diverging stress-reactivity can perform differently. Identification of blood markers of stress-reactivity is of major significance to help human performance during stress. Candidate transcripts were identified between stressed and non-stressed strains of rats' blood and brain, and overlapping significant differentially expressed genes were selected. Serum levels of human orthologues of these proteins, in lieu of blood RNA, in addition to classic stress and general clinical markers, were measured in 33 Battlefield Airmen undergoing a 52 day long preparatory training course before their course of initial entry (COIE). Blood samples and factors of affective state, negative valence "Threat" and positive valence "Challenge", were obtained five times across different days of training which included either routine physical exercise or prolonged and intense physical and mental training. During training, levels of chloride (Cl), dehydroepiandrosterone-sulfate (DHEA-S), creatinine kinase (CK), and total carbon dioxide (TCO2) differed between airmen who subsequently graduated from their COIE and those who did not. Time dependent changes of serum TCO2 and neuropeptide Y (NPY), as well as the affective factor Challenge differed by future graduation status throughout the training. Serum levels of parvin beta (PARVB) correlated with the affective factor Threat, while those of NPY, testosterone, coactosin like F-actin binding protein 1 (COTL1) and C-reactive protein (CRP) correlated with factor Challenge during the extended, intensive periods of training, consistently. These pilot data suggest that the identified panel of blood markers can measure stress responsiveness, which has the potential to advance individualized stress-management strategies.

© 2021 The Authors.

Keywords: Affective measures; Battlefield airmen; Preparatory training; Serum stress markers; Stress-severity

Conflict of interest statement

None.

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