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bioRxiv. 2021 May 03; doi: 10.1101/2021.05.01.442279.

Signaling through FcγRIIA and the C5a-C5aR pathway mediates platelet hyperactivation in COVID-19.

bioRxiv : the preprint server for biology

Sokratis A Apostolidis, Amrita Sarkar, Heather M Giannini, Rishi R Goel, Divij Mathew, Aae Suzuki, Amy E Baxter, Allison R Greenplate, Cécile Alanio, Mohamed Abdel-Hakeem, Derek A Oldridge, Josephine Giles, Jennifer E Wu, Zeyu Chen, Yinghui Jane Huang, Ajinkya Pattekar, Sasikanth Manne, Oliva Kuthuru, Jeanette Dougherty, Brittany Weiderhold, Ariel R Weisman, Caroline A G Ittner, Sigrid Gouma, Debora Dunbar, Ian Frank, Alexander C Huang, Laura A Vella, John P Reilly, Scott E Hensley, Lubica Rauova, Liang Zhao, Nuala J Meyer, Mortimer Poncz, Charles S Abrams, E John Wherry

PMID: 33972943 PMCID: PMC8109205 DOI: 10.1101/2021.05.01.442279

Abstract

ONE-SENTENCE SUMMARY: The FcγRIIA and C5a-C5aR pathways mediate platelet hyperactivation in COVID-19.

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