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Bonus M, Häussinger D, Gohlke H. Liver cell hydration and integrin signaling. Biol Chem. 2021;402(9):1033-1045doi: 10.1515/hsz-2021-0193.
Bonus, M., Häussinger, D., & Gohlke, H. (2021). Liver cell hydration and integrin signaling. Biological chemistry, 402(9), 1033-1045. https://doi.org/10.1515/hsz-2021-0193
Bonus, Michele, et al. "Liver cell hydration and integrin signaling." Biological chemistry vol. 402,9 (2021): 1033-1045. doi: https://doi.org/10.1515/hsz-2021-0193
Bonus M, Häussinger D, Gohlke H. Liver cell hydration and integrin signaling. Biol Chem. 2021 Apr 29;402(9):1033-1045. doi: 10.1515/hsz-2021-0193. Print 2021 Aug 26. PMID: 33915604.
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Biol Chem. 2021 Apr 29;402(9):1033-1045. doi: 10.1515/hsz-2021-0193. Print 2021 Aug 26.

Liver cell hydration and integrin signaling.

Biological chemistry

Michele Bonus, Dieter Häussinger, Holger Gohlke

Affiliations

  1. Institute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstr. 1, D-40225 Düsseldorf, Germany.
  2. Clinic for Gastroenterology, Hepatology, and Infectious Diseases, Heinrich Heine University Düsseldorf, Moorenstr. 5, D-40225 Düsseldorf, Germany.
  3. John von Neumann Institute for Computing (NIC), Jülich Supercomputing Centre (JSC), Wilhelm-Johnen-Str., D-52428 Jülich, Germany.
  4. Institute of Biological Information Processing (IBI-7: Structural Biochemistry), and Institute of Bio- and Geosciences (IBG-4: Bioinformatics), Forschungszentrum Jülich GmbH, Wilhelm-Johnen-Str., D-52428 Jülich, Germany.

PMID: 33915604 DOI: 10.1515/hsz-2021-0193

Abstract

Liver cell hydration (cell volume) is dynamic and can change within minutes under the influence of hormones, nutrients, and oxidative stress. Such volume changes were identified as a novel and important modulator of cell function. It provides an early example for the interaction between a physical parameter (cell volume) on the one hand and metabolism, transport, and gene expression on the other. Such events involve mechanotransduction (osmosensing) which triggers signaling cascades towards liver function (osmosignaling). This article reviews our own work on this topic with emphasis on the role of β

© 2021 Michele Bonus et al., published by De Gruyter, Berlin/Boston.

Keywords: bile acids; cell swelling; functional selectivity; mechanotransduction; molecular dynamics simulations; tauroursodeoxycholate

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