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Jang DY, Kim HS, Pack EC, et al. Development of a Method for Simultaneous Analysis of Allergenic Flavoring Agents in Cigarettes and Quantitative Risk Assessment for Consumer Safety. Toxics. 2021;9(4)doi: 10.3390/toxics9040087.
Jang, D. Y., Kim, H. S., Pack, E. C., Koo, Y. J., Lim, K. M., & Choi, D. W. (2021). Development of a Method for Simultaneous Analysis of Allergenic Flavoring Agents in Cigarettes and Quantitative Risk Assessment for Consumer Safety. Toxics, 9(4), . https://doi.org/10.3390/toxics9040087
Jang, Dae Yong, et al. "Development of a Method for Simultaneous Analysis of Allergenic Flavoring Agents in Cigarettes and Quantitative Risk Assessment for Consumer Safety." Toxics vol. 9,4 (2021). doi: https://doi.org/10.3390/toxics9040087
Jang DY, Kim HS, Pack EC, Koo YJ, Lim KM, Choi DW. Development of a Method for Simultaneous Analysis of Allergenic Flavoring Agents in Cigarettes and Quantitative Risk Assessment for Consumer Safety. Toxics. 2021 Apr 18;9(4). doi: 10.3390/toxics9040087. PMID: 33919504; PMCID: PMC8072964.
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Toxics. 2021 Apr 18;9(4). doi: 10.3390/toxics9040087.

Development of a Method for Simultaneous Analysis of Allergenic Flavoring Agents in Cigarettes and Quantitative Risk Assessment for Consumer Safety.

Toxics

Dae Yong Jang, Hyung Soo Kim, Eun Chul Pack, Ye Ji Koo, Kyung Min Lim, Dal Woong Choi

Affiliations

  1. Department of Public Health Science, Graduate School, Korea University, Seoul 02841, Korea.
  2. Health Science Research Center, Korea University, Seoul 02841, Korea.
  3. School of Health and Environmental Sciences, Korea University, Seoul 02841, Korea.
  4. College of Pharmacy, Ewha Womans University, Seoul 03670, Korea.
  5. Department of Health and Safety Convergence Science, Transdisciplinary Major in Learning Health Systems, Graduate School, Korea University, Seoul 02841, Korea.

PMID: 33919504 PMCID: PMC8072964 DOI: 10.3390/toxics9040087

Abstract

Flavoring agents are added to cigarettes to improve taste. There are mostly permitted food additives, but some of them are restricted for use in food, cosmetics, and toys, since they can cause allergic reactions. Previous studies have investigated the levels of flavoring agents in tobacco but none has focused on their content in filter tips and capsules. Moreover, no studies have assessed the risk of adding allergenic flavoring agents in cigarettes. Here, we developed and validated a simultaneous analysis method for 25 allergenic flavoring agents and menthol with gas chromatography-tandem mass spectrometry to determine levels of flavoring agents in the tobacco, filter tips, and capsules of 54 commercial cigarettes in Korea. All cigarettes contained at least one allergenic flavoring agent regardless of the inclusion of flavoring capsules. Importantly, the filter tips and the capsules contained higher levels of flavoring agents than tobacco, highlighting the importance of the quantification of flavoring agents in these parts of cigarettes. Nevertheless, the risk assessment based on their levels in cigarettes suggested that their exposure was maintained at a safe level. However, the risk assessed from maximum menthol, linalool, and cinnamaldehyde exceeded one-tenth of derived no-effect levels, suggesting the need for further studies on their risk to human health.

Keywords: allergenic flavoring agent; capsule cigarette; gas chromatography-tandem mass spectrometry; inhalation exposure; risk assessment

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