Display options
Cite
Nathanson SD, Detmar M, Padera TP, et al. Mechanisms of breast cancer metastasis. Clin Exp Metastasis. 2021;doi: 10.1007/s10585-021-10090-2.
Nathanson, S. D., Detmar, M., Padera, T. P., Yates, L. R., Welch, D. R., Beadnell, T. C., Scheid, A. D., Wrenn, E. D., & Cheung, K. (2021). Mechanisms of breast cancer metastasis. Clinical & experimental metastasis, . https://doi.org/10.1007/s10585-021-10090-2
Nathanson, S David, et al. "Mechanisms of breast cancer metastasis." Clinical & experimental metastasis vol. (2021). doi: https://doi.org/10.1007/s10585-021-10090-2
Nathanson SD, Detmar M, Padera TP, Yates LR, Welch DR, Beadnell TC, Scheid AD, Wrenn ED, Cheung K. Mechanisms of breast cancer metastasis. Clin Exp Metastasis. 2021 May 05; doi: 10.1007/s10585-021-10090-2. Epub 2021 May 05. PMID: 33950409; PMCID: PMC8568733.
Copy Download .nbib Format: NLM
Share it on

Clin Exp Metastasis. 2021 May 05; doi: 10.1007/s10585-021-10090-2. Epub 2021 May 05.

Mechanisms of breast cancer metastasis.

Clinical & experimental metastasis

S David Nathanson, Michael Detmar, Timothy P Padera, Lucy R Yates, Danny R Welch, Thomas C Beadnell, Adam D Scheid, Emma D Wrenn, Kevin Cheung

Affiliations

  1. Department of Surgery, Henry Ford Cancer Institute, 2799 W Grand Boulevard, Detroit, MI, USA. [email protected].
  2. Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland.
  3. Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  4. Wellcome Sanger Institute, Cambridge, UK.
  5. Department of Cancer Biology, University of Kansas Medical Center and University of Kansas Cancer Center, Kansas City, KS, USA.
  6. Translational Research Program, Public Health Sciences and Human Biology Divisions, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
  7. Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA, USA.

PMID: 33950409 PMCID: PMC8568733 DOI: 10.1007/s10585-021-10090-2

Abstract

Invasive breast cancer tends to metastasize to lymph nodes and systemic sites. The management of metastasis has evolved by focusing on controlling the growth of the disease in the breast/chest wall, and at metastatic sites, initially by surgery alone, then by a combination of surgery with radiation, and later by adding systemic treatments in the form of chemotherapy, hormone manipulation, targeted therapy, immunotherapy and other treatments aimed at inhibiting the proliferation of cancer cells. It would be valuable for us to know how breast cancer metastasizes; such knowledge would likely encourage the development of therapies that focus on mechanisms of metastasis and might even allow us to avoid toxic therapies that are currently used for this disease. For example, if we had a drug that targeted a gene that is critical for metastasis, we might even be able to cure a vast majority of patients with breast cancer. By bringing together scientists with expertise in molecular aspects of breast cancer metastasis, and those with expertise in the mechanical aspects of metastasis, this paper probes interesting aspects of the metastasis cascade, further enlightening us in our efforts to improve the outcome from breast cancer treatments.

Keywords: Breast cancer evolution; Cell clusters; Genes; Lymph node and systemic metastasis; Mitochondrial DNA

References

  1. Cell. 2014 Aug 28;158(5):1110-1122 - PubMed
  2. Ann Surg Oncol. 2020 Nov;27(12):4810-4818 - PubMed
  3. Nat New Biol. 1973 Apr 4;242(118):148-9 - PubMed
  4. F1000Res. 2015 Aug 12;4(F1000 Faculty Rev):550 - PubMed
  5. Cancer Res. 2015 Nov 1;75(21):4474-82 - PubMed
  6. N Engl J Med. 2004 Dec 30;351(27):2817-26 - PubMed
  7. Oncogene. 2006 Aug 7;25(34):4647-62 - PubMed
  8. Sci Adv. 2020 Jun 10;6(24):eaay9691 - PubMed
  9. J Immunol. 2013 Apr 15;190(8):4408-19 - PubMed
  10. Am J Hum Genet. 2003 Apr;72(4):804-11 - PubMed
  11. Curr Opin Immunol. 2018 Apr;51:146-153 - PubMed
  12. Science. 2017 Jul 07;357(6346):55-60 - PubMed
  13. Nature. 2020 Jul;583(7817):631-637 - PubMed
  14. Clin Chem. 2016 Mar;62(3):505-13 - PubMed
  15. Cancer Res. 2006 Aug 15;66(16):8163-71 - PubMed
  16. Nat Genet. 2016 Oct;48(10):1119-30 - PubMed
  17. Cancer Res. 2000 Jun 1;60(11):2764-9 - PubMed
  18. J Pathol. 2015 Aug;236(4):457-66 - PubMed
  19. Science. 1987 Jan 9;235(4785):177-82 - PubMed
  20. Cell. 2017 Feb 9;168(4):670-691 - PubMed
  21. Science. 2019 Mar 29;363(6434):1463-1467 - PubMed
  22. Nat Genet. 2018 Apr;50(4):613-620 - PubMed
  23. Cancer. 2001 Jun 1;91(11):2110-21 - PubMed
  24. Cell. 2011 Mar 4;144(5):646-74 - PubMed
  25. Cancer Res. 2011 Feb 1;71(3):640-4 - PubMed
  26. Cancer Res. 2015 Oct 15;75(20):4429-36 - PubMed
  27. Cancer Res. 2019 Jun 15;79(12):3011-3027 - PubMed
  28. Science. 2008 May 2;320(5876):661-4 - PubMed
  29. Nat Rev Genet. 2009 Mar;10(3):184-94 - PubMed
  30. Cancer Res. 1976 Mar;36(3):889-94 - PubMed
  31. Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):11930-5 - PubMed
  32. JAMA. 2011 Feb 9;305(6):569-75 - PubMed
  33. Nat Rev Cancer. 2016 Apr;16(4):201-18 - PubMed
  34. Nat Rev Cancer. 2009 Apr;9(4):302-12 - PubMed
  35. Bio Protoc. 2016 Oct 20;6(20): - PubMed
  36. Cancer Res. 1996 Mar 15;56(6):1222-7 - PubMed
  37. Clin Cancer Res. 2018 May 1;24(9):2214-2224 - PubMed
  38. Genome Biol. 2016 Dec 9;17(1):250 - PubMed
  39. Nature. 2002 Jan 31;415(6871):530-6 - PubMed
  40. Cell Metab. 2019 Oct 1;30(4):720-734.e5 - PubMed
  41. Trends Immunol. 2019 Feb;40(2):142-158 - PubMed
  42. Lancet. 1998 Mar 14;351(9105):793-6 - PubMed
  43. Hepatology. 2004 Mar;39(3):792-7 - PubMed
  44. Cancer Res. 2017 Dec 15;77(24):6941-6949 - PubMed
  45. Cancer. 1954 Mar;7(2):215-23 - PubMed
  46. Cell. 2013 Dec 19;155(7):1639-51 - PubMed
  47. Nature. 2016 Jan 21;529(7586):298-306 - PubMed
  48. J Clin Oncol. 2014 Nov 10;32(32):3600-6 - PubMed
  49. Nature. 2019 May;569(7757):560-564 - PubMed
  50. Nat Cell Biol. 2018 Mar;20(3):296-306 - PubMed
  51. BMC Cancer. 2016 Feb 23;16:143 - PubMed
  52. J Clin Oncol. 2014 Jul 1;32(19):1979-86 - PubMed
  53. Science. 2015 May 22;348(6237):880-6 - PubMed
  54. Cancer Metastasis Rev. 2018 Dec;37(4):633-642 - PubMed
  55. Trends Mol Med. 2020 Feb;26(2):232-241 - PubMed
  56. N Engl J Med. 2002 Aug 22;347(8):567-75 - PubMed
  57. Cancer Res. 2020 Mar 1;80(5):1118-1129 - PubMed
  58. Breast Cancer Res Treat. 2017 Feb;161(3):491-499 - PubMed
  59. Ann Oncol. 2017 Sep 1;28(9):2135-2141 - PubMed
  60. Ann Surg Oncol. 2009 Dec;16(12):3396-405 - PubMed
  61. Breast Cancer Res. 2011 Feb 01;13(1):104 - PubMed
  62. Lancet. 2002 Aug 31;360(9334):683-9 - PubMed
  63. Nature. 2015 Apr 16;520(7547):353-357 - PubMed
  64. Nat Commun. 2018 Nov 29;9(1):5079 - PubMed
  65. Cell. 2009 Dec 24;139(7):1315-26 - PubMed
  66. Nature. 2016 May 02;534(7605):47-54 - PubMed
  67. Br J Cancer. 2021 Jan;124(1):124-135 - PubMed
  68. Nat Rev Cancer. 2006 Apr;6(4):259-69 - PubMed
  69. Ann Surg Oncol. 2015 Oct;22(10):3219-24 - PubMed
  70. Cancer Res. 2017 Nov 15;77(22):6051-6059 - PubMed
  71. Dis Markers. 2001;17(2):99-109 - PubMed
  72. Nat Methods. 2014 Apr;11(4):396-8 - PubMed
  73. Clin Cancer Res. 2019 Jan 15;25(2):674-686 - PubMed
  74. Biochem J. 2013 Oct 15;455(2):157-67 - PubMed
  75. Nat Protoc. 2007;2(8):2024-32 - PubMed
  76. Cancer Cell. 2008 Jan;13(1):58-68 - PubMed
  77. Cell. 2016 Jul 28;166(3):555-566 - PubMed
  78. Cell. 2018 Jan 11;172(1-2):205-217.e12 - PubMed
  79. Nat Genet. 2014 Aug;46(8):837-843 - PubMed
  80. Ann Surg Oncol. 2018 Jul;25(7):1921-1927 - PubMed
  81. Cancer Res. 2017 Nov 15;77(22):6202-6214 - PubMed
  82. Lancet Oncol. 2014 Nov;15(12):1303-10 - PubMed
  83. Clin Cancer Res. 2015 Jun 15;21(12):2771-9 - PubMed
  84. Oncogene. 1994 Jan;9(1):255-62 - PubMed
  85. Cell. 2019 Jan 10;176(1-2):98-112.e14 - PubMed
  86. Nat Clin Pract Oncol. 2006 Aug;3(8):448-57 - PubMed
  87. Nature. 2019 Feb;566(7745):553-557 - PubMed
  88. Genes Dev. 2016 Apr 15;30(8):892-908 - PubMed
  89. Oncogene. 2018 Aug;37(35):4769-4780 - PubMed
  90. Cell. 2014 Mar 27;157(1):121-41 - PubMed
  91. Cancer Epidemiol Biomarkers Prev. 2009 Nov;18(11):3110-7 - PubMed
  92. Am J Roentgenol Radium Ther. 1949 Sep;62(3):311-9; Disc., 349-54 - PubMed
  93. Cancer Metastasis Rev. 2018 Dec;37(4):615-632 - PubMed
  94. Cancer Cell. 2018 Oct 8;34(4):549-560.e9 - PubMed
  95. Adv Cancer Res. 2019;142:63-105 - PubMed
  96. Semin Cancer Biol. 2017 Dec;47:125-146 - PubMed
  97. Proc Natl Acad Sci U S A. 2016 May 3;113(18):4947-52 - PubMed
  98. Nature. 2020 Jan;577(7788):115-120 - PubMed
  99. Biochim Biophys Acta. 2011 Jun;1807(6):620-5 - PubMed
  100. N Engl J Med. 2017 Jun 8;376(23):2211-2222 - PubMed
  101. J Natl Cancer Inst Monogr. 2001;(30):62-6 - PubMed
  102. Oncologist. 2011;16 Suppl 1:61-70 - PubMed
  103. Curr Opin Genet Dev. 2011 Feb;21(1):42-9 - PubMed
  104. Nature. 2015 Nov 12;527(7577):186-91 - PubMed
  105. Front Oncol. 2017 Dec 01;7:295 - PubMed
  106. Nat Rev Cancer. 2018 Apr;18(4):211-223 - PubMed
  107. Am J Pathol. 2009 Nov;175(5):2235-48 - PubMed
  108. Nat Commun. 2018 Sep 28;9(1):3994 - PubMed
  109. Breast Cancer Res. 2009;11(5):R75 - PubMed
  110. J Cell Biol. 2020 Sep 7;219(9): - PubMed
  111. Genome Res. 2017 Aug;27(8):1287-1299 - PubMed
  112. Nat Clin Pract Oncol. 2008 Apr;5(4):206-19 - PubMed
  113. Breast Cancer Res Treat. 2017 Jan;161(1):83-94 - PubMed
  114. Cancer Res. 2013 Dec 15;73(24):7243-53 - PubMed
  115. PLoS Genet. 2016 Sep 22;12(9):e1006267 - PubMed
  116. Nat Rev Immunol. 2018 Nov;18(11):671-688 - PubMed
  117. J Clin Invest. 2018 Apr 2;128(4):1355-1370 - PubMed
  118. Nat Rev Genet. 2003 Nov;4(11):911-6 - PubMed
  119. Science. 2018 Mar 23;359(6382):1403-1407 - PubMed
  120. Int J Cancer. 1997 Jun 11;71(6):1035-44 - PubMed
  121. Annu Rev Pathol. 2017 Jan 24;12:419-447 - PubMed
  122. Breast Cancer Res Treat. 2015 Dec;154(3):563-71 - PubMed
  123. J Biol Chem. 2018 Aug 17;293(33):12741-12748 - PubMed
  124. Cancer Med. 2016 Jun;5(6):1022-30 - PubMed
  125. N Engl J Med. 2015 Jul 23;373(4):307-16 - PubMed
  126. Cancer Cell Int. 2017 Jan 5;17:6 - PubMed
  127. PLoS Med. 2016 Dec 27;13(12):e1002204 - PubMed
  128. Cancer Discov. 2019 Jan;9(1):96-113 - PubMed
  129. N Engl J Med. 2015 Jul 23;373(4):317-27 - PubMed
  130. J Cell Biol. 2011 Feb 7;192(3):373-82 - PubMed
  131. Nat Med. 2015 Jul;21(7):751-9 - PubMed
  132. Nat Genet. 1997 Nov;17(3):280-4 - PubMed
  133. Cancer Discov. 2015 Oct;5(10):1086-97 - PubMed
  134. Nature. 2014 Aug 14;512(7513):155-60 - PubMed
  135. Ann Surg Oncol. 2007 Jun;14(6):1790-800 - PubMed
  136. Lancet Oncol. 2013 Apr;14(4):297-305 - PubMed
  137. Cold Spring Harb Perspect Biol. 2011 Feb 01;3(2): - PubMed
  138. Cancer Cell. 2017 Aug 14;32(2):169-184.e7 - PubMed
  139. Genome Res. 2014 Feb;24(2):227-40 - PubMed
  140. Nature. 2016 Dec 22;540(7634):552-558 - PubMed
  141. Int J Mol Sci. 2015 Aug 06;16(8):18224-51 - PubMed
  142. Science. 2016 Apr 8;352(6282):167-9 - PubMed
  143. Nature. 2019 Sep;573(7774):439-444 - PubMed
  144. Cell. 2015 Sep 24;163(1):33-8 - PubMed
  145. Nature. 2012 Jul 18;487(7407):330-7 - PubMed
  146. J Clin Invest. 2018 Apr 2;128(4):1371-1383 - PubMed
  147. Cancer Cell. 2003 Jun;3(6):537-49 - PubMed
  148. Nat Rev Clin Oncol. 2019 Jul;16(7):409-424 - PubMed
  149. BMC Biol. 2019 Jul 8;17(1):53 - PubMed
  150. Gynecol Oncol. 2017 May;145(2):361-365 - PubMed
  151. Cell. 2020 Oct 15;183(2):395-410.e19 - PubMed
  152. Curr Opin Biomed Eng. 2017 Sep;3:13-19 - PubMed
  153. Elife. 2013 Apr 30;2:e00358 - PubMed
  154. J Clin Oncol. 2012 Feb 10;30(5):525-32 - PubMed
  155. Nature. 2014 Apr 3;508(7494):113-7 - PubMed
  156. Genome Biol. 2013 Nov 12;14(11):R125 - PubMed
  157. Semin Cell Dev Biol. 2015 Feb;38:106-16 - PubMed
  158. Sci Rep. 2019 Mar 5;9(1):3542 - PubMed
  159. Mol Cell Biol. 1992 Mar;12(3):954-61 - PubMed
  160. Cancer Cell. 2017 Aug 14;32(2):135-154 - PubMed
  161. Clin Exp Metastasis. 2012 Oct;29(7):729-36 - PubMed
  162. Ann Surg. 1907 Jul;46(1):1-19 - PubMed
  163. Transl Oncol. 2017 Jun;10(3):431-441 - PubMed
  164. Nat Rev Cancer. 2015 Aug;15(8):473-83 - PubMed
  165. Cancer Res. 2003 Jan 15;63(2):432-40 - PubMed
  166. Biochim Biophys Acta Mol Basis Dis. 2020 May 1;1866(5):165648 - PubMed
  167. J Cell Sci. 2019 Sep 9;132(17): - PubMed
  168. Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E854-63 - PubMed
  169. J Gastroenterol. 2020 May;55(5):553-564 - PubMed
  170. Nat Cell Biol. 2019 Jul;21(7):879-888 - PubMed
  171. Proc Natl Acad Sci U S A. 2020 Mar 17;117(11):5931-5937 - PubMed
  172. Eur J Cancer. 1973 Mar;9(3):223-7 - PubMed
  173. Science. 2018 Mar 23;359(6382):1408-1411 - PubMed
  174. Nat Rev Cancer. 2012 Jan 19;12(2):144-9 - PubMed
  175. Int J Cancer. 1998 Aug 12;77(4):640-4 - PubMed
  176. PLoS Comput Biol. 2014 Jul 10;10(7):e1003703 - PubMed
  177. Cancer Cell. 2013 Oct 14;24(4):410-21 - PubMed
  178. Sci Rep. 2019 Dec 13;9(1):19107 - PubMed
  179. Cell. 2012 May 25;149(5):994-1007 - PubMed
  180. Genome Biol. 2007;8(5):R76 - PubMed
  181. JAMA. 2006 Jun 7;295(21):2492-502 - PubMed
  182. Cell. 2014 Mar 13;156(6):1298-1311 - PubMed
  183. Nat Methods. 2019 Oct;16(10):987-990 - PubMed
  184. Cancer Res. 2011 Feb 15;71(4):1214-8 - PubMed
  185. J Natl Cancer Inst. 1996 Dec 4;88(23):1731-7 - PubMed
  186. J Clin Invest. 2011 Jul;121(7):2750-67 - PubMed
  187. Clin Cancer Res. 2013 Oct 1;19(19):5533-40 - PubMed
  188. J Hepatol. 2018 Jul;69(1):89-98 - PubMed
  189. Nat Rev Cancer. 2015 Apr;15(4):248-54 - PubMed

Publication Types

Grant support