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Biotechniques. 2021 May;70(5):290-300. doi: 10.2144/btn-2020-0165. Epub 2021 May 06.

Recombinant bacterial endotoxin testing: a proven solution.

BioTechniques

Brendan Tindall, Dogan Demircioglu, Thomas Uhlig

Affiliations

  1. Industry Healthcare, bioMérieux SA, Craponne, 69290, France.
  2. Industry Healthcare, bioMérieux Germany GmbH, Nürtingen, 72622, Germany.

PMID: 33956506 DOI: 10.2144/btn-2020-0165

Abstract

Testing of parenteral pharmaceuticals and medical devices for pyrogens (fever-inducing substances) is critical to patient safety. The original rabbit pyrogen test has largely been replaced by different bacterial endotoxin tests based on

Keywords: bacterial; comparability; endotoxin; fluorescence; pyrogen; rFC; recombinant

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