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Yang G, Postoak JL, Song W, et al. Dendritic cell PIK3C3/VPS34 controls the pathogenicity of CNS autoimmunity independently of LC3-associated phagocytosis. Autophagy. 2021;1-10doi: 10.1080/15548627.2021.1922051.
Yang, G., Postoak, J. L., Song, W., Martinez, J., Zhang, J., Wu, L., & Van Kaer, L. (2021). Dendritic cell PIK3C3/VPS34 controls the pathogenicity of CNS autoimmunity independently of LC3-associated phagocytosis. Autophagy, 1-10. https://doi.org/10.1080/15548627.2021.1922051
Yang, Guan, et al. "Dendritic cell PIK3C3/VPS34 controls the pathogenicity of CNS autoimmunity independently of LC3-associated phagocytosis." Autophagy vol. (2021): 1-10. doi: https://doi.org/10.1080/15548627.2021.1922051
Yang G, Postoak JL, Song W, Martinez J, Zhang J, Wu L, Van Kaer L. Dendritic cell PIK3C3/VPS34 controls the pathogenicity of CNS autoimmunity independently of LC3-associated phagocytosis. Autophagy. 2021 May 07;1-10. doi: 10.1080/15548627.2021.1922051. Epub 2021 May 07. PMID: 33960279.
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Autophagy. 2021 May 07;1-10. doi: 10.1080/15548627.2021.1922051. Epub 2021 May 07.

Dendritic cell PIK3C3/VPS34 controls the pathogenicity of CNS autoimmunity independently of LC3-associated phagocytosis.

Autophagy

Guan Yang, J Luke Postoak, Wenqiang Song, Jennifer Martinez, Jianhua Zhang, Lan Wu, Luc Van Kaer

Affiliations

  1. Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA.
  2. Immunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
  3. Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
  4. Department of Veterans Affairs, Birmingham Veterans Affairs Medical Center, Birmingham, AL, USA.

PMID: 33960279 DOI: 10.1080/15548627.2021.1922051

Abstract

PIK3C3/VPS34 is a key player in macroautophagy/autophagy and MAP1LC3/LC3-associated phagocytosis (LAP), which play critical roles in dendritic cell (DC) function. In this study, we assessed the contribution of PIK3C3 to DC function during experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). We found that

Keywords: Autophagy; LC3-associated phagocytosis; PIK3C3/VPS34; dendritic cell; experimental autoimmune encephalomyelitis

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