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Behaegel J, Tassignon MJ, Lagali N, et al. Outcomes of Human Leukocyte Antigen-Matched Allogeneic Cultivated Limbal Epithelial Transplantation in Aniridia-Associated Keratopathy-A Single-Center Retrospective Analysis. Cornea. 2022;41(1):69-77doi: 10.1097/ICO.0000000000002729.
Behaegel, J., Tassignon, M. J., Lagali, N., Consejo, A., Koppen, C., & Ní Dhubhghaill, S. (2022). Outcomes of Human Leukocyte Antigen-Matched Allogeneic Cultivated Limbal Epithelial Transplantation in Aniridia-Associated Keratopathy-A Single-Center Retrospective Analysis. Cornea, 41(1), 69-77. https://doi.org/10.1097/ICO.0000000000002729
Behaegel, Joséphine, et al. "Outcomes of Human Leukocyte Antigen-Matched Allogeneic Cultivated Limbal Epithelial Transplantation in Aniridia-Associated Keratopathy-A Single-Center Retrospective Analysis." Cornea vol. 41,1 (2022): 69-77. doi: https://doi.org/10.1097/ICO.0000000000002729
Behaegel J, Tassignon MJ, Lagali N, Consejo A, Koppen C, Ní Dhubhghaill S. Outcomes of Human Leukocyte Antigen-Matched Allogeneic Cultivated Limbal Epithelial Transplantation in Aniridia-Associated Keratopathy-A Single-Center Retrospective Analysis. Cornea. 2022 Jan 01;41(1):69-77. doi: 10.1097/ICO.0000000000002729. PMID: 33928920; PMCID: PMC8647694.
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Cornea. 2022 Jan 01;41(1):69-77. doi: 10.1097/ICO.0000000000002729.

Outcomes of Human Leukocyte Antigen-Matched Allogeneic Cultivated Limbal Epithelial Transplantation in Aniridia-Associated Keratopathy-A Single-Center Retrospective Analysis.

Cornea

Joséphine Behaegel, Marie-José Tassignon, Neil Lagali, Alejandra Consejo, Carina Koppen, Sorcha Ní Dhubhghaill

Affiliations

  1. Ophthalmology, Visual Optics and Visual Rehabilitation, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
  2. Department of Ophthalmology, Antwerp University Hospital, Edegem, Belgium.
  3. Division of Ophthalmology, Department of Biomedical and Clinical Sciences, Faculty of Medicine, Linkoping University, Linköping, Sweden; and.
  4. Department of Applied Physics, University of Zaragoza, Zaragoza, Spain.

PMID: 33928920 PMCID: PMC8647694 DOI: 10.1097/ICO.0000000000002729

Abstract

PURPOSE: To assess the efficacy and safety of human leukocyte antigen-matched allogeneic cultivated limbal epithelial stem cell grafts in the treatment of aniridia-associated keratopathy (AAK).

METHODS: Six eyes of 6 patients with severe AAK received an allogeneic stem cell graft between January 2010 and March 2017. Anatomical and functional results were assessed at 6 months, 1 year, 2 years, and the final follow-up visit available. Safety analysis was performed by considering all perioperative and postoperative adverse events and additional surgeries required during the follow-up period.

RESULTS: The mean follow-up was 53.6 months (range 24-104 months). In most patients (80%), there was an early improvement of the keratopathy postoperatively, which slowly regressed during longer follow-up. At the final follow-up, 4 of the eyes were graded as failure and 1 eye was graded as partial success. Grading the sixth eye was not possible because of an adverse event. None of the patients maintained a total anatomical success in the long-term. Only 1 patient maintained a modest improvement in best-corrected visual acuity from hand motion to counting fingers. Four serious adverse events were recorded in 2 patients.

CONCLUSIONS: Severe AAK remains a challenging condition to manage. Transplantation of allogenic ex vivo cultivated limbal stem cells may provide a temporary improvement in ocular surface stability, but anatomical and functional results are poor in the long-term. The eyes are prone to adverse events, and any surgical treatment should take this into consideration.

Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc.

Conflict of interest statement

The authors have no conflicts of interest to disclose.

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