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Wang J, Li Y, Nie G. Multifunctional biomolecule nanostructures for cancer therapy. Nat Rev Mater. 2021;1-18doi: 10.1038/s41578-021-00315-x.
Wang, J., Li, Y., & Nie, G. (2021). Multifunctional biomolecule nanostructures for cancer therapy. Nature reviews. Materials, 1-18. https://doi.org/10.1038/s41578-021-00315-x
Wang, Jing, et al. "Multifunctional biomolecule nanostructures for cancer therapy." Nature reviews. Materials vol. (2021): 1-18. doi: https://doi.org/10.1038/s41578-021-00315-x
Wang J, Li Y, Nie G. Multifunctional biomolecule nanostructures for cancer therapy. Nat Rev Mater. 2021 May 19;1-18. doi: 10.1038/s41578-021-00315-x. Epub 2021 May 19. PMID: 34026278; PMCID: PMC8132739.
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Nat Rev Mater. 2021 May 19;1-18. doi: 10.1038/s41578-021-00315-x. Epub 2021 May 19.

Multifunctional biomolecule nanostructures for cancer therapy.

Nature reviews. Materials

Jing Wang, Yiye Li, Guangjun Nie

Affiliations

  1. CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, China, Beijing, China.
  2. Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing, China.
  3. GBA Research Innovation Institute for Nanotechnology, Guangdong, China.
  4. Henan Institute of Advanced Technology, Zhengzhou University, Zhengzhou, China.

PMID: 34026278 PMCID: PMC8132739 DOI: 10.1038/s41578-021-00315-x

Abstract

Biomolecule-based nanostructures are inherently multifunctional and harbour diverse biological activities, which can be explored for cancer nanomedicine. The supramolecular properties of biomolecules can be precisely programmed for the design of smart drug delivery vehicles, enabling efficient transport in vivo, targeted drug delivery and combinatorial therapy within a single design. In this Review, we discuss biomolecule-based nanostructures, including polysaccharides, nucleic acids, peptides and proteins, and highlight their enormous design space for multifunctional nanomedicines. We identify key challenges in cancer nanomedicine that can be addressed by biomolecule-based nanostructures and survey the distinct biological activities, programmability and in vivo behaviour of biomolecule-based nanostructures. Finally, we discuss challenges in the rational design, characterization and fabrication of biomolecule-based nanostructures, and identify obstacles that need to be overcome to enable clinical translation.

© Springer Nature Limited 2021.

Keywords: Cancer therapy; Nanotechnology in cancer

Conflict of interest statement

Competing interestsThe authors declare no competing interests.

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