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Massey AE, Malik S, Sikander M, et al. Clinical Implications of Exosomes: Targeted Drug Delivery for Cancer Treatment. Int J Mol Sci. 2021;22(10)doi: 10.3390/ijms22105278.
Massey, A. E., Malik, S., Sikander, M., Doxtater, K. A., Tripathi, M. K., Khan, S., Yallapu, M. M., Jaggi, M., Chauhan, S. C., & Hafeez, B. B. (2021). Clinical Implications of Exosomes: Targeted Drug Delivery for Cancer Treatment. International journal of molecular sciences, 22(10), . https://doi.org/10.3390/ijms22105278
Massey, Andrew E, et al. "Clinical Implications of Exosomes: Targeted Drug Delivery for Cancer Treatment." International journal of molecular sciences vol. 22,10 (2021). doi: https://doi.org/10.3390/ijms22105278
Massey AE, Malik S, Sikander M, Doxtater KA, Tripathi MK, Khan S, Yallapu MM, Jaggi M, Chauhan SC, Hafeez BB. Clinical Implications of Exosomes: Targeted Drug Delivery for Cancer Treatment. Int J Mol Sci. 2021 May 17;22(10). doi: 10.3390/ijms22105278. PMID: 34067896; PMCID: PMC8156384.
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Int J Mol Sci. 2021 May 17;22(10). doi: 10.3390/ijms22105278.

Clinical Implications of Exosomes: Targeted Drug Delivery for Cancer Treatment.

International journal of molecular sciences

Andrew E Massey, Shabnam Malik, Mohammad Sikander, Kyle A Doxtater, Manish K Tripathi, Sheema Khan, Murali M Yallapu, Meena Jaggi, Subhash C Chauhan, Bilal B Hafeez

Affiliations

  1. National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, Bethesda, MD 20892, USA.
  2. Department of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.

PMID: 34067896 PMCID: PMC8156384 DOI: 10.3390/ijms22105278

Abstract

Exosomes are nanoscale vesicles generated by cells for intercellular communication. Due to their composition, significant research has been conducted to transform these particles into specific delivery systems for various disease states. In this review, we discuss the common isolation and loading methods of exosomes, some of the major roles of exosomes in the tumor microenvironment, as well as discuss recent applications of exosomes as drug delivery vessels and the resulting clinical implications.

Keywords: exosome; lncRNAs; miRNAs; tumor microenvironment

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