Fam Cancer. 2021 Jun 14; doi: 10.1007/s10689-021-00248-y. Epub 2021 Jun 14.

First international workshop of the ATM and cancer risk group (4-5 December 2019).

Familial cancer

Fabienne Lesueur, Douglas F Easton, Anne-Laure Renault, Sean V Tavtigian, Jonine L Bernstein, Zsofia Kote-Jarai, Rosalind A Eeles, Dijana Plaseska-Karanfia, Lidia Feliubadaló, Banu Arun, Natalie Herold, Beatrix Versmold, Rita Katharina Schmutzler, Tú Nguyen-Dumont, Melissa C Southey, Leila Dorling, Alison M Dunning, Paola Ghiorzo, Bruna Samia Dalmasso, Eve Cavaciuti, Dorothée Le Gal, Nicholas J Roberts, Mev Dominguez-Valentin, Matti Rookus, Alexander M R Taylor, Alisa M Goldstein, David E Goldgar, Dominique Stoppa-Lyonnet, Nadine Andrieu

PMID: 34125377 DOI: 10.1007/s10689-021-00248-y

Abstract

The first International Workshop of the ATM and Cancer Risk group focusing on the role of Ataxia-Telangiectasia Mutated (ATM) gene in cancer was held on December 4 and 5, 2019 at Institut Curie in Paris, France. It was motivated by the fact that germline ATM pathogenic variants have been found to be associated with different cancer types. However, due to the lack of precise age-, sex-, and site-specific risk estimates, no consensus on management guidelines for variant carriers exists, and the clinical utility of ATM variant testing is uncertain. The meeting brought together epidemiologists, geneticists, biologists and clinicians to review current knowledge and on-going challenges related to ATM and cancer risk. This report summarizes the meeting sessions content that covered the latest results in family-based and population-based studies, the importance of accurate variant classification, the effect of radiation exposures for ATM variant carriers, and the characteristics of ATM-deficient tumors. The report concludes that ATM variant carriers outside of the context of Ataxia-Telangiectasia may benefit from effective cancer risk management and therapeutic strategies and that efforts to set up large-scale studies in the international framework to achieve this goal are necessary.

Keywords: ATM; Cancer risk; Cancer spectrum; Tumor profiles; Variants classification

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