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Gertzen CGW, Gohlke H, Häussinger D, et al. The many facets of bile acids in the physiology and pathophysiology of the human liver. Biol Chem. 2021;402(9):1047-1062doi: 10.1515/hsz-2021-0156.
Gertzen, C. G. W., Gohlke, H., Häussinger, D., Herebian, D., Keitel, V., Kubitz, R., Mayatepek, E., & Schmitt, L. (2021). The many facets of bile acids in the physiology and pathophysiology of the human liver. Biological chemistry, 402(9), 1047-1062. https://doi.org/10.1515/hsz-2021-0156
Gertzen, Christoph G W, et al. "The many facets of bile acids in the physiology and pathophysiology of the human liver." Biological chemistry vol. 402,9 (2021): 1047-1062. doi: https://doi.org/10.1515/hsz-2021-0156
Gertzen CGW, Gohlke H, Häussinger D, Herebian D, Keitel V, Kubitz R, Mayatepek E, Schmitt L. The many facets of bile acids in the physiology and pathophysiology of the human liver. Biol Chem. 2021 May 31;402(9):1047-1062. doi: 10.1515/hsz-2021-0156. Print 2021 Aug 26. PMID: 34049433.
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Biol Chem. 2021 May 31;402(9):1047-1062. doi: 10.1515/hsz-2021-0156. Print 2021 Aug 26.

The many facets of bile acids in the physiology and pathophysiology of the human liver.

Biological chemistry

Christoph G W Gertzen, Holger Gohlke, Dieter Häussinger, Diran Herebian, Verena Keitel, Ralf Kubitz, Ertan Mayatepek, Lutz Schmitt

Affiliations

  1. Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
  2. Center for Structural Studies (CSS), Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
  3. John von Neumann Institute for Computing (NIC), Jülich Supercomputing Centre (JSC), Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Institute of Bio- and Geosciences (IBG-4: Bioinformatics), Forschungszentrum Jülich GmbH, Jülich, Germany.
  4. Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Düsseldorf, Germany.
  5. Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
  6. Institute of Biochemistry, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

PMID: 34049433 DOI: 10.1515/hsz-2021-0156

Abstract

Bile acids perform vital functions in the human liver and are the essential component of bile. It is therefore not surprising that the biology of bile acids is extremely complex, regulated on different levels, and involves soluble and membrane receptors as well as transporters. Hereditary disorders of these proteins manifest in different pathophysiological processes that result in liver diseases of varying severity. In this review, we summarize our current knowledge of the physiology and pathophysiology of bile acids with an emphasis on recently established analytical approaches as well as the molecular mechanisms that underlie signaling and transport of bile acids. In this review, we will focus on ABC transporters of the canalicular membrane and their associated diseases. As the G protein-coupled receptor, TGR5, receives increasing attention, we have included aspects of this receptor and its interaction with bile acids.

© 2021 Christoph G.W. Gertzen et al., published by De Gruyter, Berlin/Boston.

Keywords: bile salts; hereditary diseases; liver; membrane transport

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