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Davogustto GE, Salazar RL, Vasquez HG, et al. Metabolic remodeling precedes mTORC1-mediated cardiac hypertrophy. J Mol Cell Cardiol. 2021;158:115-127doi: 10.1016/j.yjmcc.2021.05.016.
Davogustto, G. E., Salazar, R. L., Vasquez, H. G., Karlstaedt, A., Dillon, W. P., Guthrie, P. H., Martin, J. R., Vitrac, H., De La Guardia, G., Vela, D., Ribas-Latre, A., Baumgartner, C., Eckel-Mahan, K., & Taegtmeyer, H. (2021). Metabolic remodeling precedes mTORC1-mediated cardiac hypertrophy. Journal of molecular and cellular cardiology, 158115-127. https://doi.org/10.1016/j.yjmcc.2021.05.016
Davogustto, Giovanni E, et al. "Metabolic remodeling precedes mTORC1-mediated cardiac hypertrophy." Journal of molecular and cellular cardiology vol. 158 (2021): 115-127. doi: https://doi.org/10.1016/j.yjmcc.2021.05.016
Davogustto GE, Salazar RL, Vasquez HG, Karlstaedt A, Dillon WP, Guthrie PH, Martin JR, Vitrac H, De La Guardia G, Vela D, Ribas-Latre A, Baumgartner C, Eckel-Mahan K, Taegtmeyer H. Metabolic remodeling precedes mTORC1-mediated cardiac hypertrophy. J Mol Cell Cardiol. 2021 Sep;158:115-127. doi: 10.1016/j.yjmcc.2021.05.016. Epub 2021 Jun 01. PMID: 34081952; PMCID: PMC8630806.
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J Mol Cell Cardiol. 2021 Sep;158:115-127. doi: 10.1016/j.yjmcc.2021.05.016. Epub 2021 Jun 01.

Metabolic remodeling precedes mTORC1-mediated cardiac hypertrophy.

Journal of molecular and cellular cardiology

Giovanni E Davogustto, Rebecca L Salazar, Hernan G Vasquez, Anja Karlstaedt, William P Dillon, Patrick H Guthrie, Joseph R Martin, Heidi Vitrac, Gina De La Guardia, Deborah Vela, Aleix Ribas-Latre, Corrine Baumgartner, Kristin Eckel-Mahan, Heinrich Taegtmeyer

Affiliations

  1. Division of Cardiology, Department of Internal Medicine, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA.
  2. Tosoh Bioscience LLC, King of Prussia, PA, USA.
  3. Cardiovascular Pathology Research Laboratory, Texas Heart Institute at CHI St. Luke's Health, and the Department of Pathology and Laboratory Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA.
  4. Center for Metabolic and Degenerative Diseases, Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA.
  5. Division of Cardiology, Department of Internal Medicine, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA. Electronic address: [email protected].

PMID: 34081952 PMCID: PMC8630806 DOI: 10.1016/j.yjmcc.2021.05.016

Abstract

RATIONALE: The nutrient sensing mechanistic target of rapamycin complex 1 (mTORC1) and its primary inhibitor, tuberin (TSC2), are cues for the development of cardiac hypertrophy. The phenotype of mTORC1 induced hypertrophy is unknown.

OBJECTIVE: To examine the impact of sustained mTORC1 activation on metabolism, function, and structure of the adult heart.

METHODS AND RESULTS: We developed a mouse model of inducible, cardiac-specific sustained mTORC1 activation (mTORC1

CONCLUSION: Activation of mTORC1 in the adult heart triggers the development of a non-specific form of hypertrophy which is preceded by changes in cardiac glucose metabolism.

Copyright © 2021 Elsevier Ltd. All rights reserved.

Keywords: Exercise; Glycolysis; Hypertrophy; Metabolism; mTORC1

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