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Ye C, Zheng F, Wang JX, et al. Dysregulation of the Excitatory Renal Reflex in the Sympathetic Activation of Spontaneously Hypertensive Rat. Front Physiol. 2021;12:673950doi: 10.3389/fphys.2021.673950.
Ye, C., Zheng, F., Wang, J. X., Wang, X. L., Chen, Q., Li, Y. H., Kang, Y. M., & Zhu, G. Q. (2021). Dysregulation of the Excitatory Renal Reflex in the Sympathetic Activation of Spontaneously Hypertensive Rat. Frontiers in physiology, 12673950. https://doi.org/10.3389/fphys.2021.673950
Ye, Chao, et al. "Dysregulation of the Excitatory Renal Reflex in the Sympathetic Activation of Spontaneously Hypertensive Rat." Frontiers in physiology vol. 12 (2021): 673950. doi: https://doi.org/10.3389/fphys.2021.673950
Ye C, Zheng F, Wang JX, Wang XL, Chen Q, Li YH, Kang YM, Zhu GQ. Dysregulation of the Excitatory Renal Reflex in the Sympathetic Activation of Spontaneously Hypertensive Rat. Front Physiol. 2021 Jun 03;12:673950. doi: 10.3389/fphys.2021.673950. eCollection 2021. PMID: 34149454; PMCID: PMC8209386.
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Front Physiol. 2021 Jun 03;12:673950. doi: 10.3389/fphys.2021.673950. eCollection 2021.

Dysregulation of the Excitatory Renal Reflex in the Sympathetic Activation of Spontaneously Hypertensive Rat.

Frontiers in physiology

Chao Ye, Fen Zheng, Jing-Xiao Wang, Xiao-Li Wang, Qi Chen, Yue-Hua Li, Yu-Ming Kang, Guo-Qing Zhu

Affiliations

  1. Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center of Translational Medicine for Cardiovascular Disease, Department of Physiology, Nanjing Medical University, Nanjing, China.
  2. Department of Pathophysiology, Nanjing Medical University, Nanjing, China.
  3. Department of Physiology and Pathophysiology, Cardiovascular Research Center, Xi'an Jiaotong University School of Medicine, Xi'an, China.

PMID: 34149454 PMCID: PMC8209386 DOI: 10.3389/fphys.2021.673950

Abstract

Excessive sympathetic activation plays crucial roles in the pathogenesis of hypertension. Chemical stimulation of renal afferents increases the sympathetic activity and blood pressure in normal rats. This study investigated the excitatory renal reflex (ERR) in the development of hypertension in the spontaneously hypertensive rat (SHR). Experiments were performed in the Wistar-Kyoto rat (WKY) and SHR aged at 4, 12, and 24 weeks under anesthesia. Renal infusion of capsaicin was used to stimulate renal afferents, and thus, to induce ERR. The ERR was evaluated by the changes in the contralateral renal sympathetic nerve activity and mean arterial pressure. At the age of 4 weeks, the early stage with a slight or moderate hypertension, the ERR was more enhanced in SHR compared with WKY. The pressor response was greater than the sympathetic activation response in the SHR. At the age of 12 weeks, the development stage with severe hypertension, there was no significant difference in the ERR between the WKY and SHR. At the age of 24 weeks, the later stage of hypertension with long-term several hypertensions, the ERR was more attenuated in the SHR compared with the WKY. On the other hand, the pressor response to sympathetic activation due to the ERR was smaller at the age of 12 and 24 weeks than those at the age of 4 weeks. These results indicate that ERR is enhanced in the early stage of hypertension, and attenuated in the later stage of hypertension in the SHR. Abnormal ERR is involved in the sympathetic activation and the development of hypertension.

Copyright © 2021 Ye, Zheng, Wang, Wang, Chen, Li, Kang and Zhu.

Keywords: blood pressure; hypertension; kidney; renal reflex; sympathetic activity

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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