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Kahaleh M, Mahpour NY, Tyberg A, et al. Per Oral Endoscopic Myotomy for Zenker's Diverticulum: A Novel and Superior Technique Compared With Septotomy?. J Clin Gastroenterol. 2021;doi: 10.1097/MCG.0000000000001579.
Kahaleh, M., Mahpour, N. Y., Tyberg, A., Bareket, R., Shahid, H. M., Sarkar, A., Abdelqader, A., Gjeorgjievski, M., Marino, D., Kats, D., Gaidhane, M., Greenberg, I., Lee, D. P., Bushe, B., Eke, C., Sun, H., Kedia, P., Méndez, A. L. M., Lambroza, A., Barret, M., Hallit, R., Eleftheriadis, N. P., Nieto, J., Oleas, R., Robles-Medranda, C., & Bapaye, A. (2021). Per Oral Endoscopic Myotomy for Zenker's Diverticulum: A Novel and Superior Technique Compared With Septotomy?. Journal of clinical gastroenterology, . https://doi.org/10.1097/MCG.0000000000001579
Kahaleh, Michel, et al. "Per Oral Endoscopic Myotomy for Zenker's Diverticulum: A Novel and Superior Technique Compared With Septotomy?." Journal of clinical gastroenterology vol. (2021). doi: https://doi.org/10.1097/MCG.0000000000001579
Kahaleh M, Mahpour NY, Tyberg A, Bareket R, Shahid HM, Sarkar A, Abdelqader A, Gjeorgjievski M, Marino D, Kats D, Gaidhane M, Greenberg I, Lee DP, Bushe B, Eke C, Sun H, Kedia P, Méndez ALM, Lambroza A, Barret M, Hallit R, Eleftheriadis NP, Nieto J, Oleas R, Robles-Medranda C, Bapaye A. Per Oral Endoscopic Myotomy for Zenker's Diverticulum: A Novel and Superior Technique Compared With Septotomy?. J Clin Gastroenterol. 2021 Jun 29; doi: 10.1097/MCG.0000000000001579. Epub 2021 Jun 29. PMID: 34183618.
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J Clin Gastroenterol. 2021 Jun 29; doi: 10.1097/MCG.0000000000001579. Epub 2021 Jun 29.

Per Oral Endoscopic Myotomy for Zenker's Diverticulum: A Novel and Superior Technique Compared With Septotomy?.

Journal of clinical gastroenterology

Michel Kahaleh, Noah Y Mahpour, Amy Tyberg, Romy Bareket, Haroon M Shahid, Avik Sarkar, Abdelhai Abdelqader, Mihajlo Gjeorgjievski, Daniel Marino, Daniel Kats, Monica Gaidhane, Ian Greenberg, David P Lee, Bryce Bushe, Chiemeziem Eke, Hojin Sun, Prashant Kedia, Ana L M Méndez, Arnon Lambroza, Maximilien Barret, Rachel Hallit, Nikolas P Eleftheriadis, Jose Nieto, Roberto Oleas, Carlos Robles-Medranda, Amol Bapaye

Affiliations

  1. Department of Gastroenterology, Robert Wood Johnson University Hospital, New Brunswick, NJ Methodist Health System, Dallas, TX University Of Costa Rica, San José, Costa Rica Weill Cornell Medical, New York, NY Institute Cochin, Paris, Île-de-France, France Gastroenterology Unit, Endoscopy Department, Metropolitan Hospital Athens, Athens, Greece Borland Clinic, Jacksonville, FL Gastroenterology and Endoscopy Division, Ecuadorian Institute of Digestive Diseases (IECED), Guayaquil, Ecuador Deenanath Mangeshkar Hospital and Research Center, Pune, India.

PMID: 34183618 DOI: 10.1097/MCG.0000000000001579

Abstract

INTRODUCTION: Endoscopic management of Zenker diverticuli (ZD) has traditionally been via septotomy technique. The recent development of tunneling technique has shown to be both efficacious and safe. The aim of this study is to evaluate the tunneling technique using per oral endoscopic myotomy (Z-POEM) versus septotomy.

METHODS: Patients who underwent endoscopic management of ZD either by Z-POEM or septotomy from March 2017 until November 2020 from 9 international academic centers were included. Demographics, clinical data preprocedure and postprocedure, procedure time, adverse events, and hospital length of stay were analyzed.

RESULTS: A total of 101 patients (mean age 74.9 y old, 55.4% male) were included: septotomy (n=49), Z-POEM (n=52). Preprocedure Functional Oral Intake Scale score and Eckardt score was 5.3 and 5.4 for the septotomy group and 5.9 and 5.15 for the Z-POEM group. Technical success was achieved in 98% of the Z-POEM group and 100% of the septotomy group. Clinical success was achieved in 84% and 92% in the septotomy versus Z-POEM groups. Adverse events occurred in 30.6% (n=15) in septotomy group versus 9.6% (n=5) in the Z-POEM group (P=0.017). Reintervention for ongoing symptoms occurred in 7 patients in the septotomy group and 3 patients in the Z-POEM group. Mean hospital length of stay was shorter for the Z-POEM group, at 1.5 versus 1.9 days.

CONCLUSIONS: A tunneling technique via the Z-POEM procedure is an efficacious and safe endoscopic treatment for ZD. Z-POEM is a safer procedure with a statistically significant reduction in adverse events compared with traditional septotomy technique.

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