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Zhang Y, Kang JD, Zhao D, et al. Hepatic Branch Vagotomy Modulates the Gut-Liver-Brain Axis in Murine Cirrhosis. Front Physiol. 2021;12:702646doi: 10.3389/fphys.2021.702646.
Zhang, Y., Kang, J. D., Zhao, D., Ghosh, S. S., Wang, Y., Tai, Y., Gonzalez-Maeso, J., Sikaroodi, M., Gillevet, P. M., Lippman, H. R., Hylemon, P. B., Zhou, H., & Bajaj, J. S. (2021). Hepatic Branch Vagotomy Modulates the Gut-Liver-Brain Axis in Murine Cirrhosis. Frontiers in physiology, 12702646. https://doi.org/10.3389/fphys.2021.702646
Zhang, Yuan, et al. "Hepatic Branch Vagotomy Modulates the Gut-Liver-Brain Axis in Murine Cirrhosis." Frontiers in physiology vol. 12 (2021): 702646. doi: https://doi.org/10.3389/fphys.2021.702646
Zhang Y, Kang JD, Zhao D, Ghosh SS, Wang Y, Tai Y, Gonzalez-Maeso J, Sikaroodi M, Gillevet PM, Lippman HR, Hylemon PB, Zhou H, Bajaj JS. Hepatic Branch Vagotomy Modulates the Gut-Liver-Brain Axis in Murine Cirrhosis. Front Physiol. 2021 Jun 25;12:702646. doi: 10.3389/fphys.2021.702646. eCollection 2021. PMID: 34248683; PMCID: PMC8268007.
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Front Physiol. 2021 Jun 25;12:702646. doi: 10.3389/fphys.2021.702646. eCollection 2021.

Hepatic Branch Vagotomy Modulates the Gut-Liver-Brain Axis in Murine Cirrhosis.

Frontiers in physiology

Yuan Zhang, Jason D Kang, Derrick Zhao, Siddartha S Ghosh, Yanyan Wang, Yunling Tai, Javier Gonzalez-Maeso, Masoumeh Sikaroodi, Patrick M Gillevet, H Robert Lippman, Phillip B Hylemon, Huiping Zhou, Jasmohan S Bajaj

Affiliations

  1. Division of Microbiology and Immunology, Central Virginia Veterans Health Care System, Virginia Commonwealth University, Richmond, VA, United States.
  2. Division of Nephrology, Virginia Commonwealth University, Richmond, VA, United States.
  3. Department of Physiology and Biophysics, Virginia Commonwealth University, Richmond, VA, United States.
  4. Microbiome Analysis Center, George Mason University, Manassas, VA, United States.
  5. Department of Pathology, Central Virginia Veterans Health Care System, Richmond, VA, United States.
  6. Division of Gastroenterology, Hepatology, and Nutrition, Central Virginia Veterans Health Care System, Virginia Commonwealth University, Richmond, VA, United States.

PMID: 34248683 PMCID: PMC8268007 DOI: 10.3389/fphys.2021.702646

Abstract

CONCLUSIONS: Hepatic vagal innervation affects the gut microbial composition, hepatic inflammation and steatosis, and cortical inflammation and BDNF expression and could be a critical modulator of the gut-liver-brain axis with consequences for HE development.

Copyright © 2021 Zhang, Kang, Zhao, Ghosh, Wang, Tai, Gonzalez-Maeso, Sikaroodi, Gillevet, Lippman, Hylemon, Zhou and Bajaj.

Keywords: BDNF; hepatic encephalopathy; inflammation; microbiota (16S); pathobiont; vagotomy

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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