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Li Y, Yang Q, Cai D, et al. Resistin, a Novel Host Defense Peptide of Innate Immunity. Front Immunol. 2021;12:699807doi: 10.3389/fimmu.2021.699807.
Li, Y., Yang, Q., Cai, D., Guo, H., Fang, J., Cui, H., Gou, L., Deng, J., Wang, Z., & Zuo, Z. (2021). Resistin, a Novel Host Defense Peptide of Innate Immunity. Frontiers in immunology, 12699807. https://doi.org/10.3389/fimmu.2021.699807
Li, Yanran, et al. "Resistin, a Novel Host Defense Peptide of Innate Immunity." Frontiers in immunology vol. 12 (2021): 699807. doi: https://doi.org/10.3389/fimmu.2021.699807
Li Y, Yang Q, Cai D, Guo H, Fang J, Cui H, Gou L, Deng J, Wang Z, Zuo Z. Resistin, a Novel Host Defense Peptide of Innate Immunity. Front Immunol. 2021 Jun 18;12:699807. doi: 10.3389/fimmu.2021.699807. eCollection 2021. PMID: 34220862; PMCID: PMC8253364.
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Front Immunol. 2021 Jun 18;12:699807. doi: 10.3389/fimmu.2021.699807. eCollection 2021.

Resistin, a Novel Host Defense Peptide of Innate Immunity.

Frontiers in immunology

Yanran Li, Qiyuan Yang, Dongjie Cai, Hongrui Guo, Jing Fang, Hengmin Cui, Liping Gou, Junliang Deng, Zhisheng Wang, Zhicai Zuo

Affiliations

  1. Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
  2. Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, China.

PMID: 34220862 PMCID: PMC8253364 DOI: 10.3389/fimmu.2021.699807

Abstract

Resistin, a cysteine-rich protein, expressed in adipocytes, was initially proposed as a link between obesity and diabetes in mice. In humans, resistin is considered to be a pro-inflammatory molecule expressed in immune cells, which plays a regulatory role in many chronic inflammatory diseases, metabolic diseases, infectious diseases, and cancers. However, increasing evidence shows that resistin functions as a host defense peptide of innate immunity, in terms of its wide-spectrum anti-microbial activity, modulation of immunity, and limitation of microbial product-induced inflammation. To date, the understanding of resistin participating in host defense mechanism is still limited. The review aims to summarize current knowledge about the biological properties, functions, and related mechanisms of resistin in host defense, which provides new insights into the pleiotropic biological function of resistin and yields promising strategies for developing new antimicrobial therapeutic agents.

Copyright © 2021 Li, Yang, Cai, Guo, Fang, Cui, Gou, Deng, Wang and Zuo.

Keywords: anti-bacteria; anti-inflammation; host defense peptide; immunomodulation; innate immunity; resistin

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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