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Manoccio M, Esposito M, Primiceri E, et al. Femtomolar Biodetection by a Compact Core-Shell 3D Chiral Metamaterial. Nano Lett. 2021;21(14):6179-6187doi: 10.1021/acs.nanolett.1c01791.
Manoccio, M., Esposito, M., Primiceri, E., Leo, A., Tasco, V., Cuscunà, M., Zuev, D., Sun, Y., Maruccio, G., Romano, A., Quattrini, A., Gigli, G., & Passaseo, A. (2021). Femtomolar Biodetection by a Compact Core-Shell 3D Chiral Metamaterial. Nano letters, 21(14), 6179-6187. https://doi.org/10.1021/acs.nanolett.1c01791
Manoccio, Mariachiara, et al. "Femtomolar Biodetection by a Compact Core-Shell 3D Chiral Metamaterial." Nano letters vol. 21,14 (2021): 6179-6187. doi: https://doi.org/10.1021/acs.nanolett.1c01791
Manoccio M, Esposito M, Primiceri E, Leo A, Tasco V, Cuscunà M, Zuev D, Sun Y, Maruccio G, Romano A, Quattrini A, Gigli G, Passaseo A. Femtomolar Biodetection by a Compact Core-Shell 3D Chiral Metamaterial. Nano Lett. 2021 Jul 28;21(14):6179-6187. doi: 10.1021/acs.nanolett.1c01791. Epub 2021 Jul 12. PMID: 34251835.
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Nano Lett. 2021 Jul 28;21(14):6179-6187. doi: 10.1021/acs.nanolett.1c01791. Epub 2021 Jul 12.

Femtomolar Biodetection by a Compact Core-Shell 3D Chiral Metamaterial.

Nano letters

Mariachiara Manoccio, Marco Esposito, Elisabetta Primiceri, Angelo Leo, Vittorianna Tasco, Massimo Cuscunà, Dmitry Zuev, Yali Sun, Giuseppe Maruccio, Alessandro Romano, Angelo Quattrini, Giuseppe Gigli, Adriana Passaseo

Affiliations

  1. CNR NANOTEC Institute of Nanotechnology, Via Monteroni, 73100 Lecce, Italy.
  2. Department of Mathematics and Physics Ennio De Giorgi, University of Salento, Via Arnesano, 73100 Lecce, Italy.
  3. Department of Physics and Engineering, ITMO University, 49 Kronverkskiy Av., St. Petersburg 197101, Russia.
  4. Division of Neuroscience, Institute of Experimental Neurology, San Raffaele Scientific Institute, Milan 20132, Italy.

PMID: 34251835 DOI: 10.1021/acs.nanolett.1c01791

Abstract

Advanced sensing tools, detecting extremely low concentrations of circulating biomarkers, can open unexplored routes toward early diagnostics and diseases progression monitoring. Here, we demonstrate the sensing capabilities of a chip-based metamaterial, combining 3D chiral geometry with a functional core-shell nanoarchitecture. The chiral metamaterial provides a circular polarization-dependent optical response, allowing analysis in a complex environment without significant background interferences. The functional nanoarchitecture, based on the conformal coating with a polymer shell, modifies the chiral metamaterial near- and far-field optical response because of the energy transfer between dielectric shell polarization charges and plasmonic core free electrons, leading to efficient interaction with biomolecules. The system sensitivity slope is 27 nm/pM, in the detection of TAR DNA-binding protein 43, clinically relevant for neurodegenerative diseases. Measurements were performed in spiked solution and in human serum with concentrations from 1 pM down to 10 fM, which is a range not accessible with common immunological assays, opening new perspectives for next-generation biomedical systems.

Keywords: Biosensing; Chiral Metamaterials; Chiral Plasmonics; Circular Dichroism; Focused Ion Beam

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