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Golovinskaia O, Wang CK. Review of Functional and Pharmacological Activities of Berries. Molecules. 2021;26(13)doi: 10.3390/molecules26133904.
Golovinskaia, O., & Wang, C. K. (2021). Review of Functional and Pharmacological Activities of Berries. Molecules (Basel, Switzerland), 26(13), . https://doi.org/10.3390/molecules26133904
Golovinskaia, Oksana, and Wang, Chin-Kun. "Review of Functional and Pharmacological Activities of Berries." Molecules (Basel, Switzerland) vol. 26,13 (2021). doi: https://doi.org/10.3390/molecules26133904
Golovinskaia O, Wang CK. Review of Functional and Pharmacological Activities of Berries. Molecules. 2021 Jun 25;26(13). doi: 10.3390/molecules26133904. PMID: 34202412; PMCID: PMC8271923.
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Molecules. 2021 Jun 25;26(13). doi: 10.3390/molecules26133904.

Review of Functional and Pharmacological Activities of Berries.

Molecules (Basel, Switzerland)

Oksana Golovinskaia, Chin-Kun Wang

Affiliations

  1. School of Nutrition, Chung Shan Medical University, 110, Section 1, Jianguo North Road, Taichung 40201, Taiwan.

PMID: 34202412 PMCID: PMC8271923 DOI: 10.3390/molecules26133904

Abstract

Functional plant-based foods (such as fruits, vegetables, and berries) can improve health, have a preventive effect, and diminish the risk of different chronic diseases during in vivo and in vitro studies. Berries contain many phytochemicals, fibers, vitamins, and minerals. The primary phytochemicals in berry fruits are phenolic compounds including flavonoids (anthocyanins, flavonols, flavones, flavanols, flavanones, and isoflavonoids), tannins, and phenolic acids. Since berries have a high concentration of polyphenols, it is possible to use them for treating various diseases pharmacologically by acting on oxidative stress and inflammation, which are often the leading causes of diabetes, neurological, cardiovascular diseases, and cancer. This review examines commonly consumed berries: blackberries, blackcurrants, blueberries, cranberries, raspberries, black raspberries, and strawberries and their polyphenols as potential medicinal foods (due to the presence of pharmacologically active compounds) in the treatment of diabetes, cardiovascular problems, and other diseases. Moreover, much attention is paid to the bioavailability of active berry components. Hence, this comprehensive review shows that berries and their bioactive compounds possess medicinal properties and have therapeutic potential. Nevertheless, future clinical trials are required to study and improve the bioavailability of berries' phenolic compounds and extend the evidence that the active compounds of berries can be used as medicinal foods against various diseases.

Keywords: berries; bioavailability; chronic diseases; pharmaceuticals properties; phytochemicals

References

  1. Int J Mol Sci. 2019 Feb 08;20(3): - PubMed
  2. Nutrition. 2014 Feb;30(2):134-44 - PubMed
  3. Cancer Prev Res (Phila). 2009 Jan;2(1):84-93 - PubMed
  4. Cancer Prev Res (Phila). 2014 Jul;7(7):666-74 - PubMed
  5. Phytomedicine. 2021 Jun;86:153170 - PubMed
  6. J Agric Food Chem. 2005 Apr 6;53(7):2760-6 - PubMed
  7. Nutrients. 2019 Jun 25;11(6): - PubMed
  8. J Agric Food Chem. 2014 Oct 1;62(39):9458-62 - PubMed
  9. Oxid Med Cell Longev. 2016;2016:1591803 - PubMed
  10. Adv Nutr. 2016 Jul 15;7(4):706-18 - PubMed
  11. Am J Clin Nutr. 2004 May;79(5):727-47 - PubMed
  12. Mol Carcinog. 2011 Apr;50(4):291-300 - PubMed
  13. J Food Sci. 2010 Oct;75(8):H218-23 - PubMed
  14. J Clin Pharmacol. 2005 Oct;45(10):1153-64 - PubMed
  15. Biofactors. 2005;23(4):197-205 - PubMed
  16. J Agric Food Chem. 2000 Jul;48(7):2960-5 - PubMed
  17. J Agric Food Chem. 2004 Jan 28;52(2):188-95 - PubMed
  18. Cancer Prev Res (Phila). 2015 Aug;8(8):743-50 - PubMed
  19. J Agric Food Chem. 2006 Dec 13;54(25):9329-39 - PubMed
  20. J Agric Food Chem. 2006 May 31;54(11):4069-75 - PubMed
  21. Eur J Nutr. 2003 Jan;42(1):29-42 - PubMed
  22. Mol Nutr Food Res. 2019 Apr;63(8):e1800636 - PubMed
  23. Int J Mol Sci. 2018 Jan 06;19(1): - PubMed
  24. Neurotox Res. 2016 Jul;30(1):41-52 - PubMed
  25. Nutr Rev. 2015 Dec;73(12):799-822 - PubMed
  26. Oncotarget. 2015 Oct 20;6(32):33438-55 - PubMed
  27. J Agric Food Chem. 2008 Feb 13;56(3):696-704 - PubMed
  28. Mol Nutr Food Res. 2007 Jun;51(6):714-25 - PubMed
  29. J Agric Food Chem. 2002 Jun 5;50(12):3495-500 - PubMed
  30. Mol Nutr Food Res. 2009 May;53 Suppl 1:S76-84 - PubMed
  31. J Gerontol A Biol Sci Med Sci. 2019 Jun 18;74(7):967-976 - PubMed
  32. J Nutr. 2007 Jan;137(1 Suppl):186S-193S - PubMed
  33. Biochem Biophys Res Commun. 2002 Aug 23;296(3):631-6 - PubMed
  34. Mol Nutr Food Res. 2010 Mar;54(3):388-95 - PubMed
  35. Nutr Rev. 2007 Nov;65(11):490-502 - PubMed
  36. J Agric Food Chem. 2008 Feb 13;56(3):670-5 - PubMed
  37. Obesity (Silver Spring). 2015 Mar;23(3):573-80 - PubMed
  38. Nutr Rev. 2018 Jan 1;76(1):29-46 - PubMed
  39. J Agric Food Chem. 2011 Mar 23;59(6):2324-31 - PubMed
  40. Nutrition. 2012 Mar;28(3):324-30 - PubMed
  41. Neurotoxicology. 2007 Jan;28(1):93-100 - PubMed
  42. Food Funct. 2019 Oct 16;10(10):6227-6243 - PubMed
  43. Int J Mol Sci. 2018 Feb 03;19(2): - PubMed
  44. Helicobacter. 2018 Jun;23(3):e12469 - PubMed
  45. PLoS One. 2011;6(10):e25878 - PubMed
  46. J Med Food. 2010 Feb;13(1):116-22 - PubMed
  47. J Agric Food Chem. 2014 May 7;62(18):3963-71 - PubMed
  48. Crit Rev Food Sci Nutr. 2018;58(15):2491-2507 - PubMed
  49. Food Chem. 2018 Jan 1;238:134-138 - PubMed
  50. Eur J Appl Physiol. 2017 Feb;117(2):247-254 - PubMed
  51. Biomed Pharmacother. 2019 Aug;116:108999 - PubMed
  52. J Agric Food Chem. 2013 Feb 20;61(7):1477-86 - PubMed
  53. J Agric Food Chem. 2008 Feb 13;56(3):642-6 - PubMed
  54. Mol Nutr Food Res. 2007 Jun;51(6):665-74 - PubMed
  55. Ann Neurol. 2012 Jul;72(1):135-43 - PubMed
  56. Crit Rev Food Sci Nutr. 2002;42(3 Suppl):273-8 - PubMed
  57. J Nutr. 2004 Mar;134(3):613-7 - PubMed
  58. Food Chem. 2017 Feb 15;217:773-781 - PubMed
  59. J Agric Food Chem. 2005 Aug 10;53(16):6484-90 - PubMed
  60. Eur J Nutr. 2013 Mar;52(2):559-68 - PubMed
  61. Am J Clin Nutr. 2016 Sep;104(3):587-94 - PubMed
  62. J Agric Food Chem. 2010 Apr 14;58(7):3884-900 - PubMed
  63. J Nutr. 2013 Apr;143(4):430-6 - PubMed
  64. Nutr Cancer. 2006;54(1):18-32 - PubMed
  65. J Agric Food Chem. 2002 Dec 18;50(26):7731-7 - PubMed
  66. Nutr Neurosci. 2009 Jun;12(3):135-40 - PubMed
  67. Food Chem Toxicol. 2018 Mar;113:49-65 - PubMed
  68. Nutr Cancer. 2006;54(1):13-7 - PubMed
  69. J Neuroinflammation. 2016 Nov 8;13(1):286 - PubMed
  70. J Agric Food Chem. 2005 Oct 5;53(20):7721-7 - PubMed
  71. Phytochemistry. 2000 May;54(2):173-81 - PubMed
  72. J Nutr. 2004 Sep;134(9):2275-9 - PubMed
  73. J Agric Food Chem. 2010 Apr 14;58(7):3970-6 - PubMed
  74. Drug Dev Ind Pharm. 2015 May;41(5):772-9 - PubMed
  75. Mol Nutr Food Res. 2015 Jul;59(7):1264-73 - PubMed
  76. Plant Foods Hum Nutr. 2015 Dec;70(4):427-32 - PubMed
  77. J Agric Food Chem. 2005 Oct 5;53(20):7878-85 - PubMed
  78. Diagn Microbiol Infect Dis. 2004 Dec;50(4):231-5 - PubMed
  79. Nutrients. 2015 Mar 10;7(3):1696-715 - PubMed
  80. J Agric Food Chem. 2009 Sep 9;57(17):7899-906 - PubMed
  81. Clin Chim Acta. 2004 Oct;348(1-2):63-8 - PubMed
  82. J Agric Food Chem. 2010 Feb 24;58(4):2491-7 - PubMed
  83. Plant Foods Hum Nutr. 2019 Sep;74(3):300-306 - PubMed
  84. Biotechnol Lett. 2013 Apr;35(4):491-8 - PubMed
  85. Food Chem. 2013 Dec 1;141(3):2923-33 - PubMed
  86. Adv Nutr. 2016 Jan 15;7(1):44-65 - PubMed
  87. Gut. 2015 Jun;64(6):872-83 - PubMed
  88. J Agric Food Chem. 2012 Jun 13;60(23):5685-6 - PubMed
  89. Antioxid Redox Signal. 2013 May 10;18(14):1818-92 - PubMed
  90. J Med Food. 2016 Apr;19(4):346-52 - PubMed
  91. Food Funct. 2012 May;3(5):508-16 - PubMed
  92. J Nutr Biochem. 2002 May;13(5):282-288 - PubMed
  93. Antioxidants (Basel). 2020 Jan 10;9(1): - PubMed
  94. Ageing Res Rev. 2013 Jan;12(1):376-90 - PubMed
  95. Phytother Res. 2014 Mar;28(3):416-22 - PubMed
  96. J Agric Food Chem. 2010 Apr 14;58(7):3996-4000 - PubMed
  97. Food Funct. 2011 Aug;2(8):475-82 - PubMed
  98. J Food Sci. 2012 Aug;77(8):H176-83 - PubMed
  99. Food Chem. 2015 Jan 15;167:84-90 - PubMed
  100. Food Chem. 2013 Nov 15;141(2):961-6 - PubMed
  101. Nutr Cancer. 2001;40(2):125-33 - PubMed
  102. J Med Food. 2010 Oct;13(5):1027-35 - PubMed
  103. Antioxidants (Basel). 2016 Aug 18;5(3): - PubMed
  104. Phytochemistry. 2013 Nov;95:436-44 - PubMed
  105. J Agric Food Chem. 2001 Feb;49(2):969-74 - PubMed
  106. J Agric Food Chem. 2004 Dec 29;52(26):7846-56 - PubMed
  107. J Hum Hypertens. 2017 Mar;31(3):165-171 - PubMed
  108. J Nutr. 2010 Mar;140(3):527-33 - PubMed
  109. Life Sci. 2015 Mar 1;124:120-7 - PubMed
  110. Appl Microbiol Biotechnol. 2005 Apr;67(1):8-18 - PubMed
  111. J Gastroenterol Hepatol. 2021 Apr;36(4):927-935 - PubMed
  112. Nutr Neurosci. 2019 Aug;22(8):596-606 - PubMed
  113. Mol Nutr Food Res. 2016 Oct;60(10):2130-2140 - PubMed
  114. Food Funct. 2016 Oct 12;7(10):4175-4187 - PubMed
  115. Molecules. 2017 Jan 21;22(1): - PubMed
  116. J Agric Food Chem. 2005 Jan 12;53(1):28-31 - PubMed
  117. J Agric Food Chem. 2006 Dec 27;54(26):9966-77 - PubMed
  118. J Agric Food Chem. 2008 Mar 26;56(6):1880-8 - PubMed
  119. J Carcinog. 2007 Apr 18;6:4 - PubMed
  120. Mol Nutr Food Res. 2013 Dec;57(12):2258-63 - PubMed
  121. J Agric Food Chem. 2008 Aug 27;56(16):7422-30 - PubMed
  122. Int J Mol Sci. 2018 Feb 28;19(3): - PubMed
  123. PLoS One. 2012;7(10):e47021 - PubMed
  124. Eur J Nutr. 2013 Apr;52(3):949-61 - PubMed
  125. Eur J Pharmacol. 2006 Sep 1;545(1):51-64 - PubMed
  126. J Nutr Sci Vitaminol (Tokyo). 2018;64(4):258-264 - PubMed
  127. J Sci Food Agric. 2015 Jun;95(8):1584-97 - PubMed
  128. Zhongguo Zhong Yao Za Zhi. 2012 May;37(10):1460-6 - PubMed
  129. Int Urol Nephrol. 2016 Sep;48(9):1379-86 - PubMed
  130. Nutrients. 2018 May 23;10(6): - PubMed
  131. J Nutr Biochem. 2015 Nov;26(11):1166-73 - PubMed
  132. PLoS One. 2013 Aug 05;8(8):e71762 - PubMed
  133. Cancer Epidemiol Biomarkers Prev. 2007 Aug;16(8):1621-5 - PubMed
  134. PLoS One. 2013 Jul 25;8(7):e69925 - PubMed
  135. Eur J Nutr. 2020 Jun;59(4):1329-1343 - PubMed
  136. Br J Nutr. 2012 Sep;108(5):900-9 - PubMed
  137. Nutr Res. 2011 Mar;31(3):190-6 - PubMed
  138. Drug Metab Dispos. 2011 Sep;39(9):1680-8 - PubMed
  139. J Nutr. 2015 Jun;145(6):1185-93 - PubMed
  140. J Agric Food Chem. 2014 May 7;62(18):3987-96 - PubMed
  141. Brain Res Bull. 2016 Oct;127:260-269 - PubMed
  142. J Agric Food Chem. 2010 Apr 14;58(7):3992-5 - PubMed
  143. Food Nutr Res. 2017 Aug 13;61(1):1361779 - PubMed
  144. Food Chem. 2012 Jun 1;132(3):1420-1428 - PubMed
  145. J Agric Food Chem. 2007 Dec 12;55(25):10476-85 - PubMed
  146. J Nutr. 2003 May;133(5):1296-301 - PubMed
  147. Cancer Res. 2008 Jun 15;68(12):4945-57 - PubMed
  148. J Agric Food Chem. 2000 Feb;48(2):140-6 - PubMed
  149. J Med Food. 2011 Dec;14(12):1511-8 - PubMed
  150. Cancer Lett. 1994 Nov 25;87(1):55-63 - PubMed
  151. J Nutr. 2003 Jul;133(7):2125-30 - PubMed
  152. J Ethnopharmacol. 2014 Sep 29;155(3):1441-9 - PubMed
  153. Biochem Biophys Res Commun. 2008 Jul 18;372(1):57-61 - PubMed
  154. Br J Nutr. 2017 Feb;117(4):519-531 - PubMed
  155. Planta Med. 2004 Jul;70(7):620-6 - PubMed
  156. J Agric Food Chem. 2012 Jun 13;60(23):5716-27 - PubMed
  157. Clin Cancer Res. 2011 Feb 1;17(3):598-610 - PubMed
  158. J Food Sci. 2008 Nov;73(9):H241-5 - PubMed
  159. Food Funct. 2018 Dec 13;9(12):6218-6226 - PubMed
  160. Int J Mol Sci. 2015 Oct 16;16(10):24673-706 - PubMed
  161. Neurochem Int. 2016 Nov;100:1-10 - PubMed
  162. Age (Dordr). 2005 Mar;27(1):49-57 - PubMed
  163. J Food Sci. 2019 Sep;84(9):2387-2401 - PubMed
  164. J Agric Food Chem. 2002 Apr 10;50(8):2432-8 - PubMed
  165. FEMS Microbiol Lett. 2004 Mar 12;232(1):89-92 - PubMed
  166. Food Chem. 2012 Jun 1;132(3):1495-1501 - PubMed
  167. Int J Mol Sci. 2015 Jan 22;16(2):2352-65 - PubMed
  168. Pharm Res. 2010 Jun;27(6):1138-45 - PubMed
  169. Br J Pharmacol. 2017 Jun;174(11):1244-1262 - PubMed
  170. J Nutr. 2011 May;141(5):989S-1009S - PubMed
  171. J Agric Food Chem. 1999 Jun;47(6):2274-9 - PubMed
  172. Nutr Cancer. 2006;54(1):148-56 - PubMed
  173. Crit Rev Food Sci Nutr. 2004;44(1):1-17 - PubMed
  174. Cancer Prev Res (Phila). 2012 Jan;5(1):41-50 - PubMed
  175. J Agric Food Chem. 2002 Jan 30;50(3):519-25 - PubMed
  176. J Agric Food Chem. 2005 Jan 26;53(2):227-35 - PubMed
  177. J Agric Food Chem. 2007 Feb 21;55(4):1612-9 - PubMed
  178. Food Microbiol. 2019 Sep;82:202-208 - PubMed
  179. Free Radic Biol Med. 2015 Dec;89:758-69 - PubMed

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