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Son KN, Lee H, Shah D, et al. Histatin-1 is an endogenous ligand of the sigma-2 receptor. FEBS J. 2021;288(23):6815-6827doi: 10.1111/febs.16108.
Son, K. N., Lee, H., Shah, D., Kalmodia, S., Miller, R. C., Ali, M., Balasubramaniam, A., Cologna, S. M., Kong, H., Shukla, D., & Aakalu, V. K. (2021). Histatin-1 is an endogenous ligand of the sigma-2 receptor. The FEBS journal, 288(23), 6815-6827. https://doi.org/10.1111/febs.16108
Son, Kyung-No, et al. "Histatin-1 is an endogenous ligand of the sigma-2 receptor." The FEBS journal vol. 288,23 (2021): 6815-6827. doi: https://doi.org/10.1111/febs.16108
Son KN, Lee H, Shah D, Kalmodia S, Miller RC, Ali M, Balasubramaniam A, Cologna SM, Kong H, Shukla D, Aakalu VK. Histatin-1 is an endogenous ligand of the sigma-2 receptor. FEBS J. 2021 Dec;288(23):6815-6827. doi: 10.1111/febs.16108. Epub 2021 Jul 23. PMID: 34233061; PMCID: PMC8648968.
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FEBS J. 2021 Dec;288(23):6815-6827. doi: 10.1111/febs.16108. Epub 2021 Jul 23.

Histatin-1 is an endogenous ligand of the sigma-2 receptor.

The FEBS journal

Kyung-No Son, Hyun Lee, Dhara Shah, Sushma Kalmodia, Ryan Cree Miller, Marwan Ali, Arun Balasubramaniam, Stephanie M Cologna, Hyunjoon Kong, Deepak Shukla, Vinay Kumar Aakalu

Affiliations

  1. Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, IL, USA.
  2. Department of Pharmaceutical Science and Biophysics Core at Research Resources Center, University of Illinois at Chicago, IL, USA.
  3. Department of Chemical & Biomolecular Engineering, University of Illinois at Urbana-Champaign, IL, USA.
  4. Department of Chemistry, University of Illinois at Chicago, IL, USA.

PMID: 34233061 PMCID: PMC8648968 DOI: 10.1111/febs.16108

Abstract

The Sigma-2 receptor (S2R) (a.k.a TMEM97) is an important endoplasmic reticular protein involved in cancer, cholesterol processing, cell migration, and neurodegenerative diseases, including Niemann-Pick Type C. While several S2R pharmacologic agents have been discovered, its recent (2017) cloning has limited biological investigation, and no endogenous ligands of the S2R are known. Histatins are a family of endogenous antimicrobial peptides that have numerous important effects in multiple biological systems, including antifungal, antibacterial, cancer pathogenesis, immunomodulation, and wound healing. Histatin-1 (Hst1) has important roles in epithelial wound healing and cell migration, and is the primary wound healing agent in saliva. Little is understood about the downstream machinery that underpins the effects of histatins, and no mammalian receptor is known to date. In this study, we show, using biophysical methods and functional assays, that Hst1 is an endogenous ligand for S2R and that S2R is a mammalian receptor for Hst1.

© 2021 Federation of European Biochemical Societies.

Keywords: MAC30; TMEM97; antimicrobial peptide; histatin-1; migration; sigma-2 receptor; wound healing

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