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Breillat P, Pourcher V, Deshayes S, et al. AA Amyloidosis in the Course of HIV Infection: A Report of 19 Cases Including 4 New French Cases and a Comprehensive Review of Literature. Nephron. 2021;145(6):675-683doi: 10.1159/000516982.
Breillat, P., Pourcher, V., Deshayes, S., Buob, D., Cez, A., Michel, P. A., Boffa, J. J., Langlois, V., Grateau, G., & Georgin-Lavialle, S. (2021). AA Amyloidosis in the Course of HIV Infection: A Report of 19 Cases Including 4 New French Cases and a Comprehensive Review of Literature. Nephron, 145(6), 675-683. https://doi.org/10.1159/000516982
Breillat, Paul, et al. "AA Amyloidosis in the Course of HIV Infection: A Report of 19 Cases Including 4 New French Cases and a Comprehensive Review of Literature." Nephron vol. 145,6 (2021): 675-683. doi: https://doi.org/10.1159/000516982
Breillat P, Pourcher V, Deshayes S, Buob D, Cez A, Michel PA, Boffa JJ, Langlois V, Grateau G, Georgin-Lavialle S. AA Amyloidosis in the Course of HIV Infection: A Report of 19 Cases Including 4 New French Cases and a Comprehensive Review of Literature. Nephron. 2021;145(6):675-683. doi: 10.1159/000516982. Epub 2021 Jul 15. PMID: 34265778.
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Nephron. 2021;145(6):675-683. doi: 10.1159/000516982. Epub 2021 Jul 15.

AA Amyloidosis in the Course of HIV Infection: A Report of 19 Cases Including 4 New French Cases and a Comprehensive Review of Literature.

Nephron

Paul Breillat, Valérie Pourcher, Samuel Deshayes, David Buob, Alexandre Cez, Pierre-Antoine Michel, Jean-Jacques Boffa, Vincent Langlois, Gilles Grateau, Sophie Georgin-Lavialle

Affiliations

  1. Department of Internal Medicine, Sorbonne University, AP-HP, Tenon Hospital, Centre De Référence Des Maladies Auto-Inflammatoires Et Des Amyloses D'origine Inflammatoire (CEREMAIA), Paris, France.
  2. Department of Infectious Diseases, Sorbonne University, APHP, Pitié Salpétrière Hospital, INSERM 1136, Paris, France.
  3. Department of Internal Medicine, Normandie University, UNICAEN, CHU De Caen Normandie, Caen, France.
  4. Department of Biopathology, Sorbonne University, AP-HP, Tenon Hospital, Paris, France.
  5. Department of Nephrology, Sorbonne University, AP-HP, Tenon Hospital, Paris, France.
  6. Department of Internal Medicine, Jacques Monod Hospital, Le Havre, France.

PMID: 34265778 DOI: 10.1159/000516982

Abstract

INTRODUCTION: HIV infection has been recently retained as an unclear cause of AA amyloidosis. Our aim was to investigate cases of AA amyloidosis associated with HIV infection to understand if it could be considered as a cause of AA amyloidosis.

METHODS: A comprehensive literature review was conducted as well as retrospective study from French cases collected from our national reference center for AA amyloidosis.

RESULTS: Altogether, 19 patients with AA amyloidosis and HIV infection were found with 68% of men and median age at amyloidosis diagnosis of 38 years (range 28-75 years). Clinical presentation was nephrotic syndrome in 94% (n = 17/18). Among patients with renal involvement and assessable outcome (n = 17), 11 (64.7%) progressed to chronic kidney disease, with 6 (35%) end-stage renal disease. Seventy-five percent of patients had uncontrolled HIV infection and 71.4% CD4 counts <400/mm3 at amyloidosis diagnosis. Repeated or chronic bacterial or fungal infection was found in 47% of cases and a history of parenteral drug use in 55% of patients. Three patients had no classical or at least no suspected AA amyloidosis cause found or reported.

CONCLUSIONS: AA Amyloidosis is a rare condition in HIV patients with common renal involvement and significant risk of progression to chronic renal insufficiency. Because of the frequency related to other inflammatory conditions in this population, HIV is probably not an independent risk factor for AA amyloidosis.

© 2021 S. Karger AG, Basel.

Keywords: Acquired immune deficiency syndrome; Amyloidosis; Chronic inflammation; Human immunodeficiency virus infection; Nephrotic syndrome

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