Display options
Cite
Hendriks S, Peetoom K, Bakker C, et al. Global Prevalence of Young-Onset Dementia: A Systematic Review and Meta-analysis. JAMA Neurol. 2021;78(9):1080-1090doi: 10.1001/jamaneurol.2021.2161.
Hendriks, S., Peetoom, K., Bakker, C., van der Flier, W. M., Papma, J. M., Koopmans, R., Verhey, F. R. J., de Vugt, M., Köhler, S., Withall, A., Parlevliet, J. L., Uysal-Bozkir, �. �., Gibson, R. C., Neita, S. M., Nielsen, T. R., Salem, L. C., Nyberg, J., Lopes, M. A., Dominguez, J. C., De Guzman, M. F., Egeberg, A., Radford, K., Broe, T., Subramaniam, M., Abdin, E., Bruni, A. C., Di Lorenzo, R., Smith, K., Flicker, L., Mol, M. O., Basta, M., Yu, D., Masika, G., Petersen, M. S., & Ruano, L. (2021). Global Prevalence of Young-Onset Dementia: A Systematic Review and Meta-analysis. JAMA neurology, 78(9), 1080-1090. https://doi.org/10.1001/jamaneurol.2021.2161
Hendriks, Stevie, et al. "Global Prevalence of Young-Onset Dementia: A Systematic Review and Meta-analysis." JAMA neurology vol. 78,9 (2021): 1080-1090. doi: https://doi.org/10.1001/jamaneurol.2021.2161
Hendriks S, Peetoom K, Bakker C, van der Flier WM, Papma JM, Koopmans R, Verhey FRJ, de Vugt M, Köhler S, Withall A, Parlevliet JL, Uysal-Bozkir Ö, Gibson RC, Neita SM, Nielsen TR, Salem LC, Nyberg J, Lopes MA, Dominguez JC, De Guzman MF, Egeberg A, Radford K, Broe T, Subramaniam M, Abdin E, Bruni AC, Di Lorenzo R, Smith K, Flicker L, Mol MO, Basta M, Yu D, Masika G, Petersen MS, Ruano L. Global Prevalence of Young-Onset Dementia: A Systematic Review and Meta-analysis. JAMA Neurol. 2021 Sep 01;78(9):1080-1090. doi: 10.1001/jamaneurol.2021.2161. PMID: 34279544; PMCID: PMC8290331.
Copy Download .nbib Format: NLM
Share it on

JAMA Neurol. 2021 Sep 01;78(9):1080-1090. doi: 10.1001/jamaneurol.2021.2161.

Global Prevalence of Young-Onset Dementia: A Systematic Review and Meta-analysis.

JAMA neurology

Stevie Hendriks, Kirsten Peetoom, Christian Bakker, Wiesje M van der Flier, Janne M Papma, Raymond Koopmans, Frans R J Verhey, Marjolein de Vugt, Sebastian Köhler, Adrienne Withall, Juliette L Parlevliet, Özgül Uysal-Bozkir, Roger C Gibson, Susanne M Neita, Thomas Rune Nielsen, Lise C Salem, Jenny Nyberg, Marcos Antonio Lopes, Jacqueline C Dominguez, Ma Fe De Guzman, Alexander Egeberg, Kylie Radford, Tony Broe, Mythily Subramaniam, Edimansyah Abdin, Amalia C Bruni, Raffaele Di Lorenzo, Kate Smith, Leon Flicker, Merel O Mol, Maria Basta, Doris Yu, Golden Masika, Maria S Petersen, Luis Ruano

Affiliations

  1. Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, Maastricht, the Netherlands.
  2. Department of Primary and Community Care, Radboud University Medical Center, Radboud, the Netherlands.
  3. Groenhuysen, Center for Specialized Geriatric Care, Roosendaal, the Netherlands.
  4. Radboudumc Alzheimer Center, Nijmegen, the Netherlands.
  5. Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC (University Medical Center), Amsterdam, the Netherlands.
  6. Department of Epidemiology and Data Science, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.
  7. Department of Neurology, Erasmus University Medical Center, Rotterdam, the Netherlands.
  8. School of Public Health and Community Medicine, Faculty of Medicine, University of New South Wales, Sydney, Australia.
  9. Department of Internal Medicine, Section of Geriatric Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
  10. Department of Community Health and Psychiatry, University of the West Indies, Kingston, Jamaica.
  11. Department of Psychology, Faculty of Social Sciences, University of Copenhagen, Copenhagen, Denmark.
  12. Centre for Brain Repair and Rehabilitation, Institute for Neuroscience and Psychology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  13. Department of Internal Medicine, Federal University of Santa Catarina, Florianópolis, Brazil.
  14. St Luke's Medical Center, Quezon City, Metro Manila, Philippines.
  15. Department of Cardiology, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
  16. School of Medical Sciences, University of New South Wales, Sydney, Australia.
  17. Research Division, Institute of Mental Health Singapore, Singapore.
  18. Regional Neurogenetic Centre, Azienda Sanitaria Provinciale Catanzaro, Lamezia Terme, Italy.
  19. Western Australian Centre for Health and Aging, University of Western Australia, Perth, Australia.
  20. Department of Psychiatry, University Hospital of Heraklion, University of Crete, Heraklion, Greece.
  21. The Nethersole School of Nursing, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong.
  22. Department of Occupational Medicine and Public Health, The Faroese Hospital System, Tórshavn, Faroe Islands.
  23. EPIUnit-Instituto de Saude Publica, University of Porto, Porto, Portugal.

PMID: 34279544 PMCID: PMC8290331 DOI: 10.1001/jamaneurol.2021.2161

Abstract

IMPORTANCE: Reliable prevalence estimates are lacking for young-onset dementia (YOD), in which symptoms of dementia start before the age of 65 years. Such estimates are needed for policy makers to organize appropriate health care.

OBJECTIVE: To determine the global prevalence of YOD.

DATA SOURCES: The PubMed, Embase, CINAHL, and PsycInfo databases were systematically searched for population-based studies on the prevalence of YOD published between January 1, 1990, and March 31, 2020.

STUDY SELECTION: Studies containing data on the prevalence of dementia in individuals younger than 65 years were screened by 2 researchers for inclusion in a systematic review and meta-analysis.

DATA EXTRACTION AND SYNTHESIS: Prevalence estimates on 5-year age bands, from 30 to 34 years to 60 to 64 years, were extracted. Random-effects meta-analyses were conducted to pool prevalence estimates. Results were age standardized for the World Standard Population. Heterogeneity was assessed by subgroup analyses for sex, dementia subtype, study design, and economic status based on the World Bank classification and by meta-regression.

MAIN OUTCOMES AND MEASURES: Prevalence estimates of YOD for 5-year age bands.

RESULTS: A total of 95 unique studies were included in this systematic review, of which 74 with 2 760 379 unique patients were also included in 5-year age band meta-analyses. Studies were mostly conducted in Europe and in older groups in Asia, North America, and Oceania. Age-standardized prevalence estimates increased from 1.1 per 100 000 population in the group aged 30 to 34 years to 77.4 per 100 000 population in the group aged 60 to 64 years. This gives an overall global age-standardized prevalence of 119.0 per 100 000 population in the age range of 30 to 64 years, corresponding to 3.9 million people aged 30 to 64 years living with YOD in the world. Subgroup analyses showed prevalence between men and women to be similar (crude estimates for men, 216.5 per 100 000 population; for women, 293.1 per 100 000 population), whereas prevalence was lower in high-income countries (crude estimate, 663.9 per 100 000 population) compared with upper-middle-income (crude estimate, 1873.6 per 100 000 population) and lower-middle-income (crude estimate, 764.2 per 100 000 population) countries. Meta-regression showed that age range (P < .001), sample size (P < .001), and study methodology (P = .02) significantly influenced heterogeneity between studies.

CONCLUSIONS AND RELEVANCE: This systematic review and meta-analysis found an age-standardized prevalence of YOD of 119.0 per 100 000 population, although estimates of the prevalence in low-income countries and younger age ranges remain scarce. These results should help policy makers organize sufficient health care for this subgroup of individuals with dementia.

STUDY REGISTRATION: PROSPERO CRD42019119288.

Publication Types