Autophagy. 2021 Oct;17(10):3262-3263. doi: 10.1080/15548627.2021.1953849. Epub 2021 Jul 19.

The secretory function of BECN1 in metabolic regulation.

Autophagy

Kenta Kuramoto, Congcong He

PMID: 34281478 PMCID: PMC8525985 DOI: 10.1080/15548627.2021.1953849

Abstract

Macroautophagy/autophagy is primarily considered as a degradative pathway via the lysosome, yet the secretory functions of autophagy proteins have recently been unveiled. Autophagy proteins have been implicated in metabolic organ development, homeostasis and function, and deficiency in autophagy is associated with metabolic disorders. However, the molecular mechanisms by which autophagy proteins regulate energy metabolism and insulin sensitivity were unclear. We previously showed that systemic activation of autophagy by a hyperactive BECN1

Keywords: AMPK; Adiponectin; BECN1; SEC6-SEC8; adipose tissue; exocyst; glucose tolerance; insulin sensitivity; secretory pathway

References

1. Cell Rep. 2021 May 25;35(8):109184 - PubMed

Publication Types

• Journal Article
• Research Support, Non-U.S. Gov't
• Research Support, N.I.H., Extramural

Grant support

• R01 DK113170/DK/NIDDK NIH HHS/United States