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Wang HH, Li T, Portincasa P, et al. New insights into the role of . Liver Res. 2017;1(1):42-53doi: 10.1016/j.livres.2017.05.005.
Wang, H. H., Li, T., Portincasa, P., Ford, D. A., Neuschwander-Tetri, B. A., Tso, P., & Wang, D. Q. (2017). New insights into the role of . Liver research, 1(1), 42-53. https://doi.org/10.1016/j.livres.2017.05.005
Wang, Helen H, et al. "New insights into the role of ." Liver research vol. 1,1 (2017): 42-53. doi: https://doi.org/10.1016/j.livres.2017.05.005
Wang HH, Li T, Portincasa P, Ford DA, Neuschwander-Tetri BA, Tso P, Wang DQ. New insights into the role of . Liver Res. 2017 Jun;1(1):42-53. doi: 10.1016/j.livres.2017.05.005. Epub 2017 Jun 03. PMID: 34367715; PMCID: PMC8341472.
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Liver Res. 2017 Jun;1(1):42-53. doi: 10.1016/j.livres.2017.05.005. Epub 2017 Jun 03.

New insights into the role of .

Liver research

Helen H Wang, Tiangang Li, Piero Portincasa, David A Ford, Brent A Neuschwander-Tetri, Patrick Tso, David Q-H Wang

Affiliations

  1. Department of Internal Medicine, Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, St. Louis, MO, USA.
  2. Department of Pharmacology, Toxicology and Therapeutics, Kansas University Medical Center, Kansas City, KS, USA.
  3. Clinica Medica "A. Murri", Department of Biomedical Sciences and Human Oncology, University of Bari "Aldo Moro"Medical School, Bari, Italy.
  4. Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO, USA.
  5. Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

PMID: 34367715 PMCID: PMC8341472 DOI: 10.1016/j.livres.2017.05.005

Abstract

Cholesterol gallstone formation represents a failure of biliary cholesterol homeostasis in which the physical-chemical balance of cholesterol solubility in bile is disturbed. Lithogenic bile is mainly caused by persistent hepatic hypersecretion of biliary cholesterol and sustained cholesterol-supersaturated bile is an essential prerequisite for the precipitation of solid cholesterol monohydrate crystals and the formation of cholesterol gallstones. The metabolic determinants of the supply of hepatic cholesterol molecules that are recruited for biliary secretion are dependent upon the input-output balance of cholesterol and its catabolism in the liver. The sources of cholesterol for hepatic secretion into bile have been extensively investigated; however, to what extent each cholesterol source contributes to hepatic secretion is still unclear both under normal physiological conditions and in the lithogenic state. Although it has been long known that biliary lithogenicity is initiated by hepatic cholesterol hypersecretion, the genetic mechanisms that cause supersaturated bile have not been defined yet. Identification of the

Keywords: Bile acid; Bile flow; Biliary secretion; Lith gene; Micelle; Vesicle

Conflict of interest statement

Conflict of interest There is no conflict of interest to disclose for all authors.

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