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Yu Y, Yan Y, Niu F, et al. Ferroptosis: a cell death connecting oxidative stress, inflammation and cardiovascular diseases. Cell Death Discov. 2021;7(1):193doi: 10.1038/s41420-021-00579-w.
Yu, Y., Yan, Y., Niu, F., Wang, Y., Chen, X., Su, G., Liu, Y., Zhao, X., Qian, L., Liu, P., & Xiong, Y. (2021). Ferroptosis: a cell death connecting oxidative stress, inflammation and cardiovascular diseases. Cell death discovery, 7(1), 193. https://doi.org/10.1038/s41420-021-00579-w
Yu, Yi, et al. "Ferroptosis: a cell death connecting oxidative stress, inflammation and cardiovascular diseases." Cell death discovery vol. 7,1 (2021): 193. doi: https://doi.org/10.1038/s41420-021-00579-w
Yu Y, Yan Y, Niu F, Wang Y, Chen X, Su G, Liu Y, Zhao X, Qian L, Liu P, Xiong Y. Ferroptosis: a cell death connecting oxidative stress, inflammation and cardiovascular diseases. Cell Death Discov. 2021 Jul 26;7(1):193. doi: 10.1038/s41420-021-00579-w. PMID: 34312370; PMCID: PMC8313570.
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Cell Death Discov. 2021 Jul 26;7(1):193. doi: 10.1038/s41420-021-00579-w.

Ferroptosis: a cell death connecting oxidative stress, inflammation and cardiovascular diseases.

Cell death discovery

Yi Yu, Yuan Yan, Fanglin Niu, Yajun Wang, Xueyi Chen, Guodong Su, Yuru Liu, Xiling Zhao, Lu Qian, Ping Liu, Yuyan Xiong

Affiliations

  1. Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University, Xi'an, 710069, Shaanxi, China.
  2. Department of Endocrinology, Xi'an No.3 Hospital, the Affiliated Hospital of Northwest University, Xi'an, Shaanxi, 710018, P. R. China. [email protected].
  3. Department of Endocrinology, Xi'an No.3 Hospital, the Affiliated Hospital of Northwest University, Xi'an, Shaanxi, 710018, P. R. China. [email protected].
  4. Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University, Xi'an, 710069, Shaanxi, China. [email protected].

PMID: 34312370 PMCID: PMC8313570 DOI: 10.1038/s41420-021-00579-w

Abstract

Ferroptosis, a recently identified and iron-dependent cell death, differs from other cell death such as apoptosis, necroptosis, pyroptosis, and autophagy-dependent cell death. This form of cell death does not exhibit typical morphological and biochemical characteristics, including cell shrinkage, mitochondrial fragmentation, nuclear condensation. The dysfunction of lipid peroxide clearance, the presence of redox-active iron as well as oxidation of polyunsaturated fatty acid (PUFA)-containing phospholipids are three essential features of ferroptosis. Iron metabolism and lipid peroxidation signaling are increasingly recognized as central mediators of ferroptosis. Ferroptosis plays an important role in the regulation of oxidative stress and inflammatory responses. Accumulating evidence suggests that ferroptosis is implicated in a variety of cardiovascular diseases such as atherosclerosis, stroke, ischemia-reperfusion injury, and heart failure, indicating that targeting ferroptosis will present a novel therapeutic approach against cardiovascular diseases. Here, we provide an overview of the features, process, function, and mechanisms of ferroptosis, and its increasingly connected relevance to oxidative stress, inflammation, and cardiovascular diseases.

© 2021. The Author(s).

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