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Slieker RC, Donnelly LA, Fitipaldi H, et al. Distinct Molecular Signatures of Clinical Clusters in People With Type 2 Diabetes: An IMI-RHAPSODY Study. Diabetes. 2021;70(11):2683-2693doi: 10.2337/db20-1281.
Slieker, R. C., Donnelly, L. A., Fitipaldi, H., Bouland, G. A., Giordano, G. N., Åkerlund, M., Gerl, M. J., Ahlqvist, E., Ali, A., Dragan, I., Elders, P., Festa, A., Hansen, M. K., van der Heijden, A. A., Mansour Aly, D., Kim, M., Kuznetsov, D., Mehl, F., Klose, C., Simons, K., Pavo, I., Pullen, T. J., Suvitaival, T., Wretlind, A., Rossing, P., Lyssenko, V., Legido Quigley, C., Groop, L., Thorens, B., Franks, P. W., Ibberson, M., Rutter, G. A., Beulens, J. W. J., 't Hart, L. M., & Pearson, E. R. (2021). Distinct Molecular Signatures of Clinical Clusters in People With Type 2 Diabetes: An IMI-RHAPSODY Study. Diabetes, 70(11), 2683-2693. https://doi.org/10.2337/db20-1281
Slieker, Roderick C, et al. "Distinct Molecular Signatures of Clinical Clusters in People With Type 2 Diabetes: An IMI-RHAPSODY Study." Diabetes vol. 70,11 (2021): 2683-2693. doi: https://doi.org/10.2337/db20-1281
Slieker RC, Donnelly LA, Fitipaldi H, Bouland GA, Giordano GN, Åkerlund M, Gerl MJ, Ahlqvist E, Ali A, Dragan I, Elders P, Festa A, Hansen MK, van der Heijden AA, Mansour Aly D, Kim M, Kuznetsov D, Mehl F, Klose C, Simons K, Pavo I, Pullen TJ, Suvitaival T, Wretlind A, Rossing P, Lyssenko V, Legido Quigley C, Groop L, Thorens B, Franks PW, Ibberson M, Rutter GA, Beulens JWJ, 't Hart LM, Pearson ER. Distinct Molecular Signatures of Clinical Clusters in People With Type 2 Diabetes: An IMI-RHAPSODY Study. Diabetes. 2021 Nov;70(11):2683-2693. doi: 10.2337/db20-1281. Epub 2021 Aug 10. PMID: 34376475; PMCID: PMC8564413.
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Diabetes. 2021 Nov;70(11):2683-2693. doi: 10.2337/db20-1281. Epub 2021 Aug 10.

Distinct Molecular Signatures of Clinical Clusters in People With Type 2 Diabetes: An IMI-RHAPSODY Study.

Diabetes

Roderick C Slieker, Louise A Donnelly, Hugo Fitipaldi, Gerard A Bouland, Giuseppe N Giordano, Mikael Åkerlund, Mathias J Gerl, Emma Ahlqvist, Ashfaq Ali, Iulian Dragan, Petra Elders, Andreas Festa, Michael K Hansen, Amber A van der Heijden, Dina Mansour Aly, Min Kim, Dmitry Kuznetsov, Florence Mehl, Christian Klose, Kai Simons, Imre Pavo, Timothy J Pullen, Tommi Suvitaival, Asger Wretlind, Peter Rossing, Valeriya Lyssenko, Cristina Legido Quigley, Leif Groop, Bernard Thorens, Paul W Franks, Mark Ibberson, Guy A Rutter, Joline W J Beulens, Leen M 't Hart, Ewan R Pearson

Affiliations

  1. Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands.
  2. Department of Epidemiology and Data Science, Amsterdam Public Health Institute, Amsterdam UMC, location VUmc, Amsterdam, the Netherlands.
  3. Population Health & Genomics, School of Medicine, University of Dundee, Dundee, U.K.
  4. Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Department of Clinical Sciences, Clinical Research Centre, Lund University, SUS, Malmö, Sweden.
  5. Lipotype GmbH, Dresden, Germany.
  6. Steno Diabetes Center Copenhagen, Gentofte, Denmark.
  7. Vital-IT Group, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.
  8. Department of General Practice and Elderly Care Medicine, Amsterdam Public Health Research Institute, Amsterdam UMC, location VUmc, Amsterdam, the Netherlands.
  9. Eli Lilly Regional Operations GmbH, Vienna, Austria.
  10. 1st Medical Department, LK Stockerau, Niederösterreich, Austria.
  11. Cardiovascular and Metabolic Disease Research, Janssen Research & Development, Spring House, PA.
  12. Institute of Pharmaceutical Science, Faculty of Life Sciences and Medicines, King's College London, London, U.K.
  13. Department of Diabetes, Guy's Campus, King's College London, London, U.K.
  14. Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, U.K.
  15. Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
  16. Department of Clinical Science, Center for Diabetes Research, University of Bergen, Bergen, Norway.
  17. Genomics, Diabetes and Endocrinology Unit, Department of Clinical Sciences Malmö, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden.
  18. Finnish Institute of Molecular Medicine, Helsinki University, Helsinki, Finland.
  19. Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.
  20. Department of Nutrition, Harvard School of Public Health, Boston, MA.
  21. Lee Kong Chian School of Medicine, Nan Yang Technological University, Singapore.
  22. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.
  23. Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands [email protected] [email protected].
  24. Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands.
  25. Population Health & Genomics, School of Medicine, University of Dundee, Dundee, U.K. [email protected] [email protected].

PMID: 34376475 PMCID: PMC8564413 DOI: 10.2337/db20-1281

Abstract

Type 2 diabetes is a multifactorial disease with multiple underlying aetiologies. To address this heterogeneity, investigators of a previous study clustered people with diabetes according to five diabetes subtypes. The aim of the current study is to investigate the etiology of these clusters by comparing their molecular signatures. In three independent cohorts, in total 15,940 individuals were clustered based on five clinical characteristics. In a subset, genetic (

© 2021 by the American Diabetes Association.

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