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Templin AT, Schmidt C, Hogan MF, et al. Loss of apoptosis repressor with caspase recruitment domain (ARC) worsens high fat diet-induced hyperglycemia in mice. J Endocrinol. 2021;251(2):125-135doi: 10.1530/JOE-20-0612.
Templin, A. T., Schmidt, C., Hogan, M. F., Esser, N., Kitsis, R. N., Hull, R. L., Zraika, S., & Kahn, S. E. (2021). Loss of apoptosis repressor with caspase recruitment domain (ARC) worsens high fat diet-induced hyperglycemia in mice. The Journal of endocrinology, 251(2), 125-135. https://doi.org/10.1530/JOE-20-0612
Templin, Andrew T, et al. "Loss of apoptosis repressor with caspase recruitment domain (ARC) worsens high fat diet-induced hyperglycemia in mice." The Journal of endocrinology vol. 251,2 (2021): 125-135. doi: https://doi.org/10.1530/JOE-20-0612
Templin AT, Schmidt C, Hogan MF, Esser N, Kitsis RN, Hull RL, Zraika S, Kahn SE. Loss of apoptosis repressor with caspase recruitment domain (ARC) worsens high fat diet-induced hyperglycemia in mice. J Endocrinol. 2021 Sep 20;251(2):125-135. doi: 10.1530/JOE-20-0612. PMID: 34382577; PMCID: PMC8651217.
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J Endocrinol. 2021 Sep 20;251(2):125-135. doi: 10.1530/JOE-20-0612.

Loss of apoptosis repressor with caspase recruitment domain (ARC) worsens high fat diet-induced hyperglycemia in mice.

The Journal of endocrinology

Andrew T Templin, Christine Schmidt, Meghan F Hogan, Nathalie Esser, Richard N Kitsis, Rebecca L Hull, Sakeneh Zraika, Steven E Kahn

Affiliations

  1. Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Veteran Affairs Puget Sound Health Care System and University of Washington, Seattle, Washington, USA.
  2. Departments of Medicine and Cell Biology and Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, Bronx, New York, USA.

PMID: 34382577 PMCID: PMC8651217 DOI: 10.1530/JOE-20-0612

Abstract

Apoptosis repressor with caspase recruitment domain (ARC) is an endogenous inhibitor of cell death signaling that is expressed in insulin-producing β cells. ARC has been shown to reduce β-cell death in response to diabetogenic stimuli in vitro, but its role in maintaining glucose homeostasis in vivo has not been fully established. Here we examined whether loss of ARC in FVB background mice exacerbates high fat diet (HFD)-induced hyperglycemia in vivo over 24 weeks. Prior to commencing 24-week HFD, ARC-/- mice had lower body weight than wild type (WT) mice. This body weight difference was maintained until the end of the study and was associated with decreased epididymal and inguinal adipose tissue mass in ARC-/- mice. Non-fasting plasma glucose was not different between ARC-/- and WT mice prior to HFD feeding, and ARC-/- mice displayed a greater increase in plasma glucose over the first 4 weeks of HFD. Plasma glucose remained elevated in ARC-/- mice after 16 weeks of HFD feeding, at which time it had returned to baseline in WT mice. Following 24 weeks of HFD, non-fasting plasma glucose in ARC-/- mice returned to baseline and was not different from WT mice. At this final time point, no differences were observed between genotypes in plasma glucose or insulin under fasted conditions or following intravenous glucose administration. However, HFD-fed ARC-/- mice exhibited significantly decreased β-cell area compared to WT mice. Thus, ARC deficiency delays, but does not prevent, metabolic adaptation to HFD feeding in mice, worsening transient HFD-induced hyperglycemia.

Keywords: ARC; cell death; diabetes; islet; β cell

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