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Wang J, Chen B, Sha M, et al. Positive and neutral updating reconsolidate aversive episodic memories via different routes. Neurobiol Learn Mem. 2021;184:107500doi: 10.1016/j.nlm.2021.107500.
Wang, J., Chen, B., Sha, M., Gu, Y., Wu, H., Forcato, C., & Qin, S. (2021). Positive and neutral updating reconsolidate aversive episodic memories via different routes. Neurobiology of learning and memory, 184107500. https://doi.org/10.1016/j.nlm.2021.107500
Wang, Jingyi, et al. "Positive and neutral updating reconsolidate aversive episodic memories via different routes." Neurobiology of learning and memory vol. 184 (2021): 107500. doi: https://doi.org/10.1016/j.nlm.2021.107500
Wang J, Chen B, Sha M, Gu Y, Wu H, Forcato C, Qin S. Positive and neutral updating reconsolidate aversive episodic memories via different routes. Neurobiol Learn Mem. 2021 Oct;184:107500. doi: 10.1016/j.nlm.2021.107500. Epub 2021 Aug 10. PMID: 34389448.
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Neurobiol Learn Mem. 2021 Oct;184:107500. doi: 10.1016/j.nlm.2021.107500. Epub 2021 Aug 10.

Positive and neutral updating reconsolidate aversive episodic memories via different routes.

Neurobiology of learning and memory

Jingyi Wang, Boxuan Chen, Manqi Sha, Yiran Gu, Haitao Wu, Cecilia Forcato, Shaozheng Qin

Affiliations

  1. State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Faculty of Psychology at Beijing Normal University, Beijing, China. Electronic address: [email protected].
  2. State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Faculty of Psychology at Beijing Normal University, Beijing, China.
  3. Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), Institute of Brain Functional Genomics, School of Life Science, NYU-ECNU Institute of Brain and Cognitive Science, East China Normal University, Shanghai, China.
  4. Department of Neurobiology, Beijing Institute of Basic Medical Sciences, Beijing, China; Chinese Institute for Brain Research, Beijing, China.
  5. Laboratorio de Sueño y Memoria, Depto. De Ciencias de la Vida, Instituto Tecnológico de Buenos Aires (ITBA), Av. Madero 399, (1106) Capital Federal, Buenos Aires, Argentina.
  6. State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Faculty of Psychology at Beijing Normal University, Beijing, China; Chinese Institute for Brain Research, Beijing, China. Electronic address: [email protected].

PMID: 34389448 DOI: 10.1016/j.nlm.2021.107500

Abstract

Aversive memories are long-lasting and prone to burden our emotional wellbeing and mental health. Yet, how to remedy the maladaptive effects of aversive memories remains elusive. Using memory reactivation and emotional updating manipulations, we investigated how positive and neutral emotion may update aversive memories for reconsolidation in humans. We found that positive updating after reactivation was equivalent to neutral updating in impairing true memories of a previous aversive event after a 12-hour wakeful delay, but induced more false memory. Moreover, additional 12-hour delay with overnight sleep did not further enlarge true memory differences, but attenuated the effect of reactivation and updating on false memory. Interestingly, the neutral rather than the positive updating reduced the emotional arousal of the aversive memory 24 h later. Our findings could serve as a reference for real-world therapeutic applications regarding how positive and neutral updating may reshape aversive memories, especially when taking wake- and sleep-filled reconsolidation into account.

Copyright © 2021 Elsevier Inc. All rights reserved.

Keywords: Emotion; Episodic memory; False memory; Reconsolidation; Updating

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