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Chen J, Su Y, Lin F, et al. Effect of paraquat on cytotoxicity involved in oxidative stress and inflammatory reaction: A review of mechanisms and ecological implications. Ecotoxicol Environ Saf. 2021;224:112711doi: 10.1016/j.ecoenv.2021.112711.
Chen, J., Su, Y., Lin, F., Iqbal, M., Mehmood, K., Zhang, H., & Shi, D. (2021). Effect of paraquat on cytotoxicity involved in oxidative stress and inflammatory reaction: A review of mechanisms and ecological implications. Ecotoxicology and environmental safety, 224112711. https://doi.org/10.1016/j.ecoenv.2021.112711
Chen, Jiaxin, et al. "Effect of paraquat on cytotoxicity involved in oxidative stress and inflammatory reaction: A review of mechanisms and ecological implications." Ecotoxicology and environmental safety vol. 224 (2021): 112711. doi: https://doi.org/10.1016/j.ecoenv.2021.112711
Chen J, Su Y, Lin F, Iqbal M, Mehmood K, Zhang H, Shi D. Effect of paraquat on cytotoxicity involved in oxidative stress and inflammatory reaction: A review of mechanisms and ecological implications. Ecotoxicol Environ Saf. 2021 Aug 26;224:112711. doi: 10.1016/j.ecoenv.2021.112711. Epub 2021 Aug 26. PMID: 34455184.
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Ecotoxicol Environ Saf. 2021 Aug 26;224:112711. doi: 10.1016/j.ecoenv.2021.112711. Epub 2021 Aug 26.

Effect of paraquat on cytotoxicity involved in oxidative stress and inflammatory reaction: A review of mechanisms and ecological implications.

Ecotoxicology and environmental safety

Jiaxin Chen, Yalin Su, Fei Lin, Mujahid Iqbal, Khalid Mehmood, Hui Zhang, Dayou Shi

Affiliations

  1. College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
  2. Department of Pathology, Cholistan University of Veterinary and Animal Sciences (CUVAS), Bahawalpur 63100, Pakistan.
  3. Department of Clinical Medicine and Surgery, Faculty of Veterinary and Animal Sciences, The Islamia University of Bahawalpur, 63100, Pakistan.
  4. College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China. Electronic address: [email protected].
  5. College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China. Electronic address: [email protected].

PMID: 34455184 DOI: 10.1016/j.ecoenv.2021.112711

Abstract

Paraquat (PQ) is a cheap and an effective herbicide, which is widely being used worldwide to remove weeds in cultivated crop fields. However, it can cause soil and water pollution, and pose serious harm to the environment and organisms. Several countries have started to limit or prohibit the use of PQ because of the increasing number of human deaths. Its toxicity can damage the organisms with a multi-target mechanism, which has not been fully understood yet. That is why it is hard to treat as well. The current research on PQ focuses on its targeted organ, the lungs, in which PQ mostly trigger pulmonary fibrosis. While there is a lack of systematic research, there are few studies published discussing its toxic effects at systematic level. This review summarizes the major damages caused by PQ in different organisms and partial mechanisms by which it causes these damages. For this purpose, we consulted several research articles that studied the toxicity of PQ in various tissues. We also listed some drugs that can be used to alleviate the toxicity of PQ. However, at present, the effectiveness of these drugs is still being explored in animal experiments and the study of their mechanism will also help in understanding the poisoning mechanism of PQ, which will ultimately lead to effective treatment in future.

Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

Keywords: Environment; Organisms; Paraquat; Toxicity

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