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Karazurna NA, Porter CM, Aytur S, et al. Associations between dietary fatty acid patterns and cognitive function in the Hispanic Community Health Study/Study of Latinos. Br J Nutr. 2021;1-35doi: 10.1017/S0007114521003275.
Karazurna, N. A., Porter, C. M., Aytur, S., Scott, T., Mattei, J., Noel, S. E., Gonzalez, H. M., Mossavar-Rahmani, Y., Sotres-Alvarez, D., Gallo, L. C., Daviglus, M. L., Van Horn, L., Elfassy, T., Gellman, M. D., Moncrieft, A. E., Tucker, K. L., Kaplan, R. C., & Bigornia, S. J. (2021). Associations between dietary fatty acid patterns and cognitive function in the Hispanic Community Health Study/Study of Latinos. The British journal of nutrition, 1-35. https://doi.org/10.1017/S0007114521003275
Karazurna, Nicole A, et al. "Associations between dietary fatty acid patterns and cognitive function in the Hispanic Community Health Study/Study of Latinos." The British journal of nutrition vol. (2021): 1-35. doi: https://doi.org/10.1017/S0007114521003275
Karazurna NA, Porter CM, Aytur S, Scott T, Mattei J, Noel SE, Gonzalez HM, Mossavar-Rahmani Y, Sotres-Alvarez D, Gallo LC, Daviglus ML, Van Horn L, Elfassy T, Gellman MD, Moncrieft AE, Tucker KL, Kaplan RC, Bigornia SJ. Associations between dietary fatty acid patterns and cognitive function in the Hispanic Community Health Study/Study of Latinos. Br J Nutr. 2021 Aug 26;1-35. doi: 10.1017/S0007114521003275. Epub 2021 Aug 26. PMID: 34433507.
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Br J Nutr. 2021 Aug 26;1-35. doi: 10.1017/S0007114521003275. Epub 2021 Aug 26.

Associations between dietary fatty acid patterns and cognitive function in the Hispanic Community Health Study/Study of Latinos.

The British journal of nutrition

Nicole A Karazurna, Caitlin M Porter, Semra Aytur, Tammy Scott, Josiemer Mattei, Sabrina E Noel, Hector M Gonzalez, Yasmin Mossavar-Rahmani, Daniela Sotres-Alvarez, Linda C Gallo, Martha L Daviglus, Linda Van Horn, Tali Elfassy, Marc D Gellman, Ashley E Moncrieft, Katherine L Tucker, Robert C Kaplan, Sherman J Bigornia

Affiliations

  1. Department of Agriculture Nutrition and Food Systems, University of New Hampshire.
  2. Department of Health Management and Policy, University of New Hampshire.
  3. Department of Psychiatry, Tufts University.
  4. Department of Nutrition, Harvard T.H. Chan School of Public Health.
  5. Department of Biomedical and Nutritional Sciences, University of Massachusetts Lowell.
  6. Department of Neurosciences, University of California, San Diego.
  7. Department of Epidemiology and Population Health, Albert Einstein College of Medicine.
  8. Department of Biostatistics, University of North Carolina, Gillings School of Public Health.
  9. Department of Psychology, San Diego State University.
  10. Department of Medicine, University of Illinois at Chicago.
  11. Department of Preventative Medicine, Northwestern University.
  12. Department of Medicine, University of Miami.
  13. Department of Psychology, University of Miami.
  14. Department of Center for Applied Research Care, University of South Carolina.
  15. Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109.

PMID: 34433507 DOI: 10.1017/S0007114521003275

Abstract

Our objective was to quantify the cross-sectional associations between dietary fatty acid (DFA) patterns and cognitive function among Hispanic/Latino adults. This study included data from 8,942 participants of the Hispanic Community Health Study/Study of Latinos, a population-based cohort study (weighted age 56.2 y and proportion female 55.2%). The NCI (National Cancer Institute) method was used to estimate dietary intake from two 24-hr recalls. We derived DFA patterns using principal components analysis with 26 fatty acid and total plant and animal monounsaturated fatty acid (MUFA) input variables. Global cognitive function was calculated as the average z-score of 4 neurocognitive tests. Survey linear regression models included multiple potential confounders such as age, sex, education, depressive symptoms, physical activity, energy intake, and cardiovascular disease. DFA patterns were characterized by consumption of long-chain saturated fatty acids (SFA), animal-based MUFA, and trans fatty acids (Factor 1); short to medium-chain SFA (Factor 2); very-long-chain omega-3 polyunsaturated fatty acids (PUFA) (Factor 3); very-long-chain SFA and plant-based MUFA and PUFA (Factor 4). Factor 2 was associated with greater scores for global cognitive function (β=0.037 ± 0.012) and the Digit Symbol Substitution (DSS) (β=0.56±0.17), Brief Spanish English Verbal Learning-Sum (B-SEVLT) (β=0.23 ± 0.11), and B-SEVLT-Recall (β=0.11 ± 0.05) tests (P<0.05 for all). Factors 1 (β=0.04 ± 0.01) and 4 (β=0.70 ± 0.18) were associated with the DSS test (P<0.05 for all). Consumption of short to medium-chain SFA may be associated with higher cognitive function among U.S.-residing Hispanic/Latino adults. Prospective studies are necessary to confirm these findings.

Keywords: Cognitive function; Dietary Patterns; Fatty Acids; Hispanic/Latinos

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