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Webb LM, Phythian-Adams AT, Costain AH, et al. Plasmacytoid Dendritic Cells Facilitate Th Cell Cytokine Responses throughout . Immunohorizons. 2021;5(8):721-732doi: 10.4049/immunohorizons.2100071.
Webb, L. M., Phythian-Adams, A. T., Costain, A. H., Brown, S. L., Lundie, R. J., Forde-Thomas, J., Cook, P. C., Jackson-Jones, L. H., Marley, A. K., Smits, H. H., Hoffmann, K. F., Tait Wojno, E. D., & MacDonald, A. S. (2021). Plasmacytoid Dendritic Cells Facilitate Th Cell Cytokine Responses throughout . ImmunoHorizons, 5(8), 721-732. https://doi.org/10.4049/immunohorizons.2100071
Webb, Lauren M, et al. "Plasmacytoid Dendritic Cells Facilitate Th Cell Cytokine Responses throughout ." ImmunoHorizons vol. 5,8 (2021): 721-732. doi: https://doi.org/10.4049/immunohorizons.2100071
Webb LM, Phythian-Adams AT, Costain AH, Brown SL, Lundie RJ, Forde-Thomas J, Cook PC, Jackson-Jones LH, Marley AK, Smits HH, Hoffmann KF, Tait Wojno ED, MacDonald AS. Plasmacytoid Dendritic Cells Facilitate Th Cell Cytokine Responses throughout . Immunohorizons. 2021 Aug 30;5(8):721-732. doi: 10.4049/immunohorizons.2100071. PMID: 34462311.
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Immunohorizons. 2021 Aug 30;5(8):721-732. doi: 10.4049/immunohorizons.2100071.

Plasmacytoid Dendritic Cells Facilitate Th Cell Cytokine Responses throughout .

ImmunoHorizons

Lauren M Webb, Alexander T Phythian-Adams, Alice H Costain, Sheila L Brown, Rachel J Lundie, Josephine Forde-Thomas, Peter C Cook, Lucy H Jackson-Jones, Angela K Marley, Hermelijn H Smits, Karl F Hoffmann, Elia D Tait Wojno, Andrew S MacDonald

Affiliations

  1. Department of Immunology, University of Washington, Seattle, WA; [email protected] [email protected].
  2. Department of Immunology, University of Washington, Seattle, WA.
  3. Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, United Kingdom.
  4. Department of Parasitology, Leiden University Medical Center, Leiden, the Netherlands.
  5. 360biolabs, Melbourne, Victoria, Australia.
  6. Institute of Biological, Environmental and Rural Sciences, Aberystwyth University, Aberystwyth, United Kingdom.
  7. Medical Research Council Centre for Medical Mycology, University of Exeter, Exeter, United Kingdom.
  8. Division of Biomedical and Life Sciences, Lancaster University, Lancaster, United Kingdom; and.
  9. Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom.
  10. Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, United Kingdom; [email protected] [email protected].

PMID: 34462311 DOI: 10.4049/immunohorizons.2100071

Abstract

Plasmacytoid dendritic cells (pDCs) are potent producers of type I IFN (IFN-I) during viral infection and respond to IFN-I in a positive feedback loop that promotes their function. IFN-I shapes dendritic cell responses during helminth infection, impacting their ability to support Th2 responses. However, the role of pDCs in type 2 inflammation is unclear. Previous studies have shown that pDCs are dispensable for hepatic or splenic Th2 responses during the early stages of murine infection with the trematode

Copyright © 2021 The Authors.

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