Display options
Cite
Fraitag S, Boccara O. What to Look Out for in a Newborn with Multiple Papulonodular Skin Lesions at Birth. Dermatopathology (Basel). 2021;8(3):390-417doi: 10.3390/dermatopathology8030043.
Fraitag, S., & Boccara, O. (2021). What to Look Out for in a Newborn with Multiple Papulonodular Skin Lesions at Birth. Dermatopathology (Basel, Switzerland), 8(3), 390-417. https://doi.org/10.3390/dermatopathology8030043
Fraitag, Sylvie, and Boccara, Olivia. "What to Look Out for in a Newborn with Multiple Papulonodular Skin Lesions at Birth." Dermatopathology (Basel, Switzerland) vol. 8,3 (2021): 390-417. doi: https://doi.org/10.3390/dermatopathology8030043
Fraitag S, Boccara O. What to Look Out for in a Newborn with Multiple Papulonodular Skin Lesions at Birth. Dermatopathology (Basel). 2021 Aug 17;8(3):390-417. doi: 10.3390/dermatopathology8030043. PMID: 34449594; PMCID: PMC8395860.
Copy Download .nbib Format: NLM
Share it on

Dermatopathology (Basel). 2021 Aug 17;8(3):390-417. doi: 10.3390/dermatopathology8030043.

What to Look Out for in a Newborn with Multiple Papulonodular Skin Lesions at Birth.

Dermatopathology (Basel, Switzerland)

Sylvie Fraitag, Olivia Boccara

Affiliations

  1. Department of Pathology, Necker-Enfants Malades Hospital, APHP, 75015 Paris, France.
  2. Department of Dermatology, Necker-Enfants Malades Hospital, APHP, 75015 Paris, France.

PMID: 34449594 PMCID: PMC8395860 DOI: 10.3390/dermatopathology8030043

Abstract

Multiple papulonodular skin lesions at birth can indicate the presence of various benign and malignant disorders. Although the lesions' clinical aspect (color and consistency, in particular) may steer the clinician towards one disorder or another (infantile myofibromatosis, xanthogranuloma, or metastatic neuroblastoma), the diagnosis can only be confirmed by the histopathologic assessment of a biopsy. In neonates, a rapid but accurate diagnosis is critical because skin lesions may be the first manifestation of a malignant disorder like leukemia cutis or metastatic neuroblastoma. Here, we review the various disorders that may manifest themselves as multiple skin lesions at birth.

Keywords: Langerhans cell histiocytosis; blue rubber bleb nevus syndrome; blueberry muffin rash; dermal erythropoiesis; glomuveinous malformation; infantile myofibromatosis; leukemia cutis; lymphangioendotheliomatosis with thrombocytopenia; mastocytosis; metastatic neuroblastoma; metastatic rhabdoid tumor; metastatic rhabdomyosarcoma; multiple juvenile xanthogranuloma; multiple neonatal hemangiomatosis; newborn; subcutaneous fat necrosis of the newborn

References

  1. Melanoma Res. 2010 Dec;20(6):443-9 - PubMed
  2. J Am Acad Dermatol. 2014 Aug;71(2):264-70 - PubMed
  3. J Am Acad Dermatol. 2008 Feb;58(2 Suppl):S12-5 - PubMed
  4. Am J Surg Pathol. 2003 May;27(5):579-93 - PubMed
  5. Pediatr Blood Cancer. 2016 Mar;63(3):486-92 - PubMed
  6. Int J Dermatol. 1999 Sep;38(9):693-6 - PubMed
  7. Pediatr Dev Pathol. 2005 Jul-Aug;8(4):407-19 - PubMed
  8. J Cutan Pathol. 2015 Oct;42(10):757-64 - PubMed
  9. J Pediatr Surg. 1988 Apr;23(4):315-8 - PubMed
  10. Pediatr Blood Cancer. 2021 Jan;68(1):e28576 - PubMed
  11. Am J Dermatopathol. 1999 Dec;21(6):557-61 - PubMed
  12. Arch Dermatol. 2009 Jul;145(7):847-8 - PubMed
  13. Br J Dermatol. 2018 Oct;179(4):925-932 - PubMed
  14. Cancer. 2001 Feb 1;91(3):606-12 - PubMed
  15. Mod Pathol. 2017 Sep;30(9):1234-1240 - PubMed
  16. Arch Dermatol. 2006 Jul;142(7):892-6 - PubMed
  17. Curr Opin Pediatr. 2009 Jun;21(3):373-8 - PubMed
  18. Case Rep Pediatr. 2014;2014:104652 - PubMed
  19. Gynecol Oncol Case Rep. 2012 May 08;2(3):102-4 - PubMed
  20. Am J Dermatopathol. 2019 Jan;41(1):29-36 - PubMed
  21. Br J Dermatol. 2007 Apr;156(4):709-15 - PubMed
  22. J Am Acad Dermatol. 1989 Aug;21(2 Pt 2):347-51 - PubMed
  23. Ann Dermatol Venereol. 2011 Aug-Sep;138(8-9):586-90 - PubMed
  24. Arch Dermatol. 2004 May;140(5):599-606 - PubMed
  25. Pediatr Dermatol. 2011 Mar-Apr;28(2):85-93 - PubMed
  26. J Am Acad Dermatol. 2007 Feb;56(2):290-4 - PubMed
  27. J Pediatr. 2020 Jul 2;: - PubMed
  28. Eur J Pediatr. 2004 Jan;163(1):1-6 - PubMed
  29. JAMA Dermatol. 2019 Aug 1;155(8):946-950 - PubMed
  30. Int J Dermatol. 2014 Apr;53(4):e247-50 - PubMed
  31. Pediatr Dermatol. 2021 Mar;38(2):464-468 - PubMed
  32. J Am Acad Dermatol. 1989 Jun;20(6):1104-10 - PubMed
  33. Arch Dermatol. 2010 Feb;146(2):149-56 - PubMed
  34. Lancet. 2003 May 10;361(9369):1617-20 - PubMed
  35. Am J Dermatopathol. 1998 Aug;20(4):403-7 - PubMed
  36. Pediatr Dermatol. 2020 Sep;37(5):972-973 - PubMed
  37. Pediatrics. 1967 Oct;40(4):627-35 - PubMed
  38. Pediatrics. 2015 Aug;136(2):e517-22 - PubMed
  39. J Pediatr Surg. 2010 Mar;45(3):619-26 - PubMed
  40. Acta Derm Venereol. 2015 Sep;95(7):860-1 - PubMed

Publication Types