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New Phytol. 2021 Dec;232(5):1959-1973. doi: 10.1111/nph.17691. Epub 2021 Sep 16.

Serrate-Associated Protein 1, a splicing-related protein, promotes miRNA biogenesis in Arabidopsis.

The New phytologist

Mu Li, Huihui Yu, Kan Liu, Weilong Yang, Bangjun Zhou, Lu Gan, Shengjun Li, Chi Zhang, Bin Yu

Affiliations

  1. School of Biological Sciences & Center for Plant Science Innovation, University of Nebraska-Lincoln, Lincoln, NE, 68588-0666, USA.
  2. Key Laboratory of Biofuels, Shandong Provincial Key Laboratory of Energy Genetics, Shandong Institute of Energy Technology, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, 266101, China.

PMID: 34449907 PMCID: PMC8568667 DOI: 10.1111/nph.17691

Abstract

MicroRNAs (miRNAs) are essential regulators of gene expression in metazoans and plants. In plants, most miRNAs are generated from primary miRNA transcripts (pri-miRNAs), which are processed by the Dicer-like 1 (DCL1) complex along with accessory proteins. Serrate-Associated Protein 1 (SEAP1), a conserved splicing-related protein, has been studied in human and yeast. However, the functions of SEAP1 in plants remain elusive. Lack of SEAP1 results in embryo lethality and knockdown of SEAP1 by an artificial miRNA (amiR

© 2021 The Authors. New Phytologist © 2021 New Phytologist Foundation.

Keywords: Arabidopsis; DCL1; SE and HYL1; SEAP1; miRNA biogenesis; splicing

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