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Kwak SS, Yoo S, Avila R, et al. Skin-Integrated Devices with Soft, Holey Architectures for Wireless Physiological Monitoring, With Applications in the Neonatal Intensive Care Unit. Adv Mater. 2021;33(44):e2103974doi: 10.1002/adma.202103974.
Kwak, S. S., Yoo, S., Avila, R., Chung, H. U., Jeong, H., Liu, C., Vogl, J. L., Kim, J., Yoon, H. J., Park, Y., Ryu, H., Lee, G., Kim, J., Koo, J., Oh, Y. S., Kim, S., Xu, S., Zhao, Z., Xie, Z., Huang, Y., & Rogers, J. A. (2021). Skin-Integrated Devices with Soft, Holey Architectures for Wireless Physiological Monitoring, With Applications in the Neonatal Intensive Care Unit. Advanced materials (Deerfield Beach, Fla.), 33(44), e2103974. https://doi.org/10.1002/adma.202103974
Kwak, Sung Soo, et al. "Skin-Integrated Devices with Soft, Holey Architectures for Wireless Physiological Monitoring, With Applications in the Neonatal Intensive Care Unit." Advanced materials (Deerfield Beach, Fla.) vol. 33,44 (2021): e2103974. doi: https://doi.org/10.1002/adma.202103974
Kwak SS, Yoo S, Avila R, Chung HU, Jeong H, Liu C, Vogl JL, Kim J, Yoon HJ, Park Y, Ryu H, Lee G, Kim J, Koo J, Oh YS, Kim S, Xu S, Zhao Z, Xie Z, Huang Y, Rogers JA. Skin-Integrated Devices with Soft, Holey Architectures for Wireless Physiological Monitoring, With Applications in the Neonatal Intensive Care Unit. Adv Mater. 2021 Nov;33(44):e2103974. doi: 10.1002/adma.202103974. Epub 2021 Sep 12. PMID: 34510572.
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Adv Mater. 2021 Nov;33(44):e2103974. doi: 10.1002/adma.202103974. Epub 2021 Sep 12.

Skin-Integrated Devices with Soft, Holey Architectures for Wireless Physiological Monitoring, With Applications in the Neonatal Intensive Care Unit.

Advanced materials (Deerfield Beach, Fla.)

Sung Soo Kwak, Seonggwang Yoo, Raudel Avila, Ha Uk Chung, Hyoyoung Jeong, Claire Liu, Jamie L Vogl, Joohee Kim, Hong-Joon Yoon, Yoonseok Park, Hanjun Ryu, Geumbee Lee, Jihye Kim, Jahyun Koo, Yong Suk Oh, Sungbong Kim, Shuai Xu, Zichen Zhao, Zhaoqian Xie, Yonggang Huang, John A Rogers

Affiliations

  1. Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, 60208, USA.
  2. Department of Mechanical Engineering, Northwestern University, Evanston, IL, 60208, USA.
  3. Sibel Health, Niles, IL, 60714, USA.
  4. Department of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA.
  5. Division of Pediatric Autonomic Medicine, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 60611, USA.
  6. School of Biomedical Engineering, Korea University, Seoul, 02841, Republic of Korea.
  7. Interdisciplinary Program in Precision Public Health, Korea University, Seoul, 02841, Republic of Korea.
  8. Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology, Daejeon, 34141, Republic of Korea.
  9. Department of Materials Science and Engineering, University of Illinois at Urbana Champaign, Urbana, IL, 61801, USA.
  10. Department of Dermatology, Division of Dermatology, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
  11. State Key Laboratory of Structural Analysis for Industrial Equipment, Department of Engineering Mechanics, Dalian University of Technology, Dalian, 116024, China.
  12. Ningbo Institute of Dalian University of Technology, Ningbo, 315016, China.
  13. Department of Civil and Environmental Engineering, Northwestern University, Evanston, IL, 60208, USA.
  14. Department of Materials Science and Engineering, Northwestern University, Evanston, IL, 60208, USA.
  15. Department of Chemistry, Northwestern University, Evanston, IL, 60208, USA.
  16. Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
  17. Department of Electrical and Computer Engineering, Northwestern University, Evanston, IL, 60208, USA.

PMID: 34510572 DOI: 10.1002/adma.202103974

Abstract

Continuous monitoring of vital signs is an essential aspect of operations in neonatal and pediatric intensive care units (NICUs and PICUs), of particular importance to extremely premature and/or critically ill patients. Current approaches require multiple sensors taped to the skin and connected via hard-wired interfaces to external data acquisition electronics. The adhesives can cause iatrogenic injuries to fragile, underdeveloped skin, and the wires can complicate even the most routine tasks in patient care. Here, materials strategies and design concepts are introduced that significantly improve these platforms through the use of optimized materials, open (i.e., "holey") layouts and precurved designs. These schemes 1) reduce the stresses at the skin interface, 2) facilitate release of interfacial moisture from transepidermal water loss, 3) allow visual inspection of the skin for rashes or other forms of irritation, 4) enable triggered reduction of adhesion to reduce the probability for injuries that can result from device removal. A combination of systematic benchtop testing and computational modeling identifies the essential mechanisms and key considerations. Demonstrations on adult volunteers and on a neonate in an operating NICUs illustrate a broad range of capabilities in continuous, clinical-grade monitoring of conventional vital signs, and unconventional indicators of health status.

© 2021 Wiley-VCH GmbH.

Keywords: electrocardiogram; neonates; pediatrics; physiological monitoring; soft electronics; wireless wearables

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