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Boffano P, Cavarra F, Tricarico G, et al. The epidemiology and management of ameloblastomas: A European multicenter study. J Craniomaxillofac Surg. 2021;doi: 10.1016/j.jcms.2021.09.007.
Boffano, P., Cavarra, F., Tricarico, G., Masu, L., Brucoli, M., Ruslin, M., Forouzanfar, T., Ridwan-Pramana, A., Rodríguez-Santamarta, T., Rui Ranz, M., de Vicente, J. C., Starch-Jensen, T., Pechalova, P., Pavlov, N., Doykova, I., Konstantinovic, V. S., Jelovac, D., Barrabé, A., Louvrier, A., Meyer, C., Tamme, T., Andrianov, A., Dovšak, T., Birk, A., Hresko, A., Chepurnyi, Y., Kopchak, A., Snäll, J., Hagström, J., Rasmusson, L., & Rocchetti, V. (2021). The epidemiology and management of ameloblastomas: A European multicenter study. Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, . https://doi.org/10.1016/j.jcms.2021.09.007
Boffano, Paolo, et al. "The epidemiology and management of ameloblastomas: A European multicenter study." Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery vol. (2021). doi: https://doi.org/10.1016/j.jcms.2021.09.007
Boffano P, Cavarra F, Tricarico G, Masu L, Brucoli M, Ruslin M, Forouzanfar T, Ridwan-Pramana A, Rodríguez-Santamarta T, Rui Ranz M, de Vicente JC, Starch-Jensen T, Pechalova P, Pavlov N, Doykova I, Konstantinovic VS, Jelovac D, Barrabé A, Louvrier A, Meyer C, Tamme T, Andrianov A, Dovšak T, Birk A, Hresko A, Chepurnyi Y, Kopchak A, Snäll J, Hagström J, Rasmusson L, Rocchetti V. The epidemiology and management of ameloblastomas: A European multicenter study. J Craniomaxillofac Surg. 2021 Sep 23; doi: 10.1016/j.jcms.2021.09.007. Epub 2021 Sep 23. PMID: 34583885.
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J Craniomaxillofac Surg. 2021 Sep 23; doi: 10.1016/j.jcms.2021.09.007. Epub 2021 Sep 23.

The epidemiology and management of ameloblastomas: A European multicenter study.

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery

Paolo Boffano, Francesco Cavarra, Gerardo Tricarico, Lavinia Masu, Matteo Brucoli, Muhammad Ruslin, Tymour Forouzanfar, Angela Ridwan-Pramana, Tanía Rodríguez-Santamarta, Marta Rui Ranz, Juan Carlos de Vicente, Thomas Starch-Jensen, Petia Pechalova, Nikolai Pavlov, Iva Doykova, Vitomir S Konstantinovic, Drago Jelovac, Aude Barrabé, Aurélien Louvrier, Christophe Meyer, Tiia Tamme, Aleksei Andrianov, Tadej Dovšak, Anže Birk, Andrii Hresko, Yurii Chepurnyi, Andrii Kopchak, Johanna Snäll, Jaana Hagström, Lars Rasmusson, Vincenzo Rocchetti

Affiliations

  1. Division of Dentistry, Vercelli Hospital, Vercelli, Italy. Electronic address: [email protected].
  2. Division of Dentistry, Vercelli Hospital, Vercelli, Italy.
  3. Division of Pathology, Vercelli Hospital, Vercelli, Italy.
  4. Division of Maxillofacial Surgery, University Hospital "Maggiore della Carità", University of Eastern Piedmont, Novara, Italy.
  5. Department of Oral and Maxillofacial Surgery, Hasanuddin University, Makassar, Indonesia.
  6. Department of Oral and Maxillofacial Surgery/Oral Pathology, VU University Medical Center, Amsterdam, the Netherlands.
  7. Servicio de Cirugía Maxilofacial, Hospital Universitario Central de Asturias, Oviedo, Spain.
  8. Department of Oral and Maxillofacial Surgery, Aalborg University Hospital, Aalborg, Denmark.
  9. Department of Oral Durgery, Faculty of Dental medicine, Medical University of Plovdiv, Bulgaria.
  10. Clinic of Maxillofacial Surgery, University Hospital "St. George", Plovdiv, Bulgaria.
  11. Department of Maxillofacial Murgery, Faculty of Dental Sedicine, Medical University of Plovdiv, Bulgaria.
  12. School of Dental Medicine, University of Belgrade, Belgrade, Serbia.
  13. Department of Oral and Maxillofacial Surgery - Hospital Dentistry Unit, University Hospital of Besançon, France.
  14. Department of Oral and Maxillofacial Surgery - Hospital Dentistry Unit, University Hospital of Besançon, France; University of Franche-Comté, INSERM, EFS BFC, UMR 1098 Interactions Hôte-Greffon-Tumeur/Ingénierie Cellulaire et Génique, 25000, Besançon, France.
  15. Department of Oral and Maxillofacial Surgery - Hospital Dentistry Unit, University Hospital of Besançon, France; University of Franche-Comté, EA 4662 Nanomedicine Lab Imagery and Therapeutics, 25000, Besançon, France.
  16. Department of Stomatology, University of Tartu, Estonia.
  17. Department of Maxillofacial and Oral Surgery of the University Medical Centre, Ljubljana, Slovenia.
  18. Kyiv Regional Hospital, Kyiv, Ukraine.
  19. O. Bohomolets National Medical University, Kyiv, Ukraine.
  20. Department of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  21. Department of Oral Pathology and Radiology, University of Turku, Turku, Finland; Department of Pathology, Helsinki University and Helsinki University Hospital, Helsinki, Finland.
  22. Department of Oral and Maxillofacial Surgery, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

PMID: 34583885 DOI: 10.1016/j.jcms.2021.09.007

Abstract

The present study aimed at assessing the epidemiology including demographic variables, diagnostic features, and management of ameloblastomas at several European departments of maxillofacial and oral surgery. The following data were recorded for each patient: gender, age, voluptuary habits, comorbidities, site, size, radiographic features, type, histopathological features, kind of treatment, length of hospital stay, complications, recurrence, management and complications of the recurrence. A total of 244 patients, 134 males and 110 females with ameloblastomas were included in the study. Mean age was 47.4 years. In all, 81% of lesions were found in the mandible, whereas 19% were found in the maxilla. Mean size of included ameloblastomas was 38.9 mm. The most frequently performed treatment option was enucleation plus curettage/peripheral ostectomy in 94 ameloblastomas, followed by segmental resection (60 patients), simple enucleation (46 patients), and marginal resection (40 patients). A recurrence (with a mean follow up of 5 years) was observed in 47 cases out of 244 ameloblastomas (19.3%). Segmental resection was associated with a low risk of recurrence (p = 0003), whereas enucleation plus curettage/peripheral ostectomy was associated with a high risk of recurrence (p = 0002). A multilocular radiographic appearance was associated with a high risk of recurrence (p < .05), as well as the benign solid/multicystic histologic type (p < .05). Within the limitations of the study it seems that the management of ameloblastomas will probably remain controversial even in the future. Balancing low surgical morbidity with a low recurrence rate is a difficult aim to reach.

Copyright © 2021 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

Keywords: Ameloblastoma; Epidemiology; Recurrence; Surgery; Treatment

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