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Lafoz E, Campreciós G, García-Calderó H, et al. Impact of lifestyle interventions targeting physical exercise and caloric intake on cirrhosis regression in rats. Am J Physiol Gastrointest Liver Physiol. 2021;321(6):G603-G616doi: 10.1152/ajpgi.00191.2021.
Lafoz, E., Campreciós, G., García-Calderó, H., Anton, A., Vilaseca, M., Ruart, M., Guasch, E., Garrabou, G., Delgado, T. C., Martínez-Chantar, M. L., García-Martínez, R., Gracia-Sancho, J., Hernández-Gea, V., & García-Pagán, J. C. (2021). Impact of lifestyle interventions targeting physical exercise and caloric intake on cirrhosis regression in rats. American journal of physiology. Gastrointestinal and liver physiology, 321(6), G603-G616. https://doi.org/10.1152/ajpgi.00191.2021
Lafoz, Erica, et al. "Impact of lifestyle interventions targeting physical exercise and caloric intake on cirrhosis regression in rats." American journal of physiology. Gastrointestinal and liver physiology vol. 321,6 (2021): G603-G616. doi: https://doi.org/10.1152/ajpgi.00191.2021
Lafoz E, Campreciós G, García-Calderó H, Anton A, Vilaseca M, Ruart M, Guasch E, Garrabou G, Delgado TC, Martínez-Chantar ML, García-Martínez R, Gracia-Sancho J, Hernández-Gea V, García-Pagán JC. Impact of lifestyle interventions targeting physical exercise and caloric intake on cirrhosis regression in rats. Am J Physiol Gastrointest Liver Physiol. 2021 Dec 01;321(6):G603-G616. doi: 10.1152/ajpgi.00191.2021. Epub 2021 Sep 29. PMID: 34585619.
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Am J Physiol Gastrointest Liver Physiol. 2021 Dec 01;321(6):G603-G616. doi: 10.1152/ajpgi.00191.2021. Epub 2021 Sep 29.

Impact of lifestyle interventions targeting physical exercise and caloric intake on cirrhosis regression in rats.

American journal of physiology. Gastrointestinal and liver physiology

Erica Lafoz, Genís Campreciós, Héctor García-Calderó, Aina Anton, Marina Vilaseca, Maria Ruart, Eduard Guasch, Glòria Garrabou, Teresa C Delgado, María-Luz Martínez-Chantar, Rita García-Martínez, Jordi Gracia-Sancho, Virginia Hernández-Gea, Juan Carlos García-Pagán

Affiliations

  1. Barcelona Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Clínic, Universitat de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
  2. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain.
  3. Institut Clínic Cardiovascular, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.
  4. Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.
  5. Muscle Research and Mitochondrial Function Laboratory, CELLEX-IDIBAPS, University of Barcelona, Barcelona, Spain.
  6. CIBERER-Spanish Biomedical Research Centre in Rare Diseases, Madrid, Spain.
  7. Liver Disease Laboratory, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain.
  8. Servicio de Medicina Interna, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

PMID: 34585619 DOI: 10.1152/ajpgi.00191.2021

Abstract

In patients, advanced cirrhosis only regresses partially once the etiological agent is withdrawn. Animal models for advanced cirrhosis regression are missing. Lifestyle interventions (LIs) have been shown to improve steatosis, inflammation, fibrosis, and portal pressure (PP) in liver disease. We aimed at characterizing cirrhosis regression after etiological agent removal in experimental models of advanced cirrhosis and to study the impact of different LI on it. Advanced cirrhosis was induced in rats either by carbon tetrachloride (CCl

Keywords: ammonia; decompensated cirrhosis; hepatic fibrosis; moderate exercise; portal hypertension

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