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Kaushik S, Tasset I, Arias E, et al. Autophagy and the hallmarks of aging. Ageing Res Rev. 2021;72:101468doi: 10.1016/j.arr.2021.101468.
Kaushik, S., Tasset, I., Arias, E., Pampliega, O., Wong, E., Martinez-Vicente, M., & Cuervo, A. M. (2021). Autophagy and the hallmarks of aging. Ageing research reviews, 72101468. https://doi.org/10.1016/j.arr.2021.101468
Kaushik, Susmita, et al. "Autophagy and the hallmarks of aging." Ageing research reviews vol. 72 (2021): 101468. doi: https://doi.org/10.1016/j.arr.2021.101468
Kaushik S, Tasset I, Arias E, Pampliega O, Wong E, Martinez-Vicente M, Cuervo AM. Autophagy and the hallmarks of aging. Ageing Res Rev. 2021 Dec;72:101468. doi: 10.1016/j.arr.2021.101468. Epub 2021 Sep 24. PMID: 34563704; PMCID: PMC8616816.
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Ageing Res Rev. 2021 Dec;72:101468. doi: 10.1016/j.arr.2021.101468. Epub 2021 Sep 24.

Autophagy and the hallmarks of aging.

Ageing research reviews

Susmita Kaushik, Inmaculada Tasset, Esperanza Arias, Olatz Pampliega, Esther Wong, Marta Martinez-Vicente, Ana Maria Cuervo

Affiliations

  1. Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, NY, USA; Institute for Aging Studies, Albert Einstein College of Medicine, NY, USA.
  2. Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, NY, USA; Institute for Aging Studies, Albert Einstein College of Medicine, NY, USA; Departmento de Bioquimica y Biologia Molecular, Universidad de Cordoba, Cordoba, Spain.
  3. Institute for Aging Studies, Albert Einstein College of Medicine, NY, USA; Department of Medicine, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, NY, USA.
  4. Achucarro Basque Center for Neuroscience, Departmento de Neurosciencias, Universidad del Pais Vasco (UPV/EHU), 48940 Leioa, Spain.
  5. Centre for Healthy Longevity, National University Health System, Healthy Longevity Translational Research Programme, Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  6. Autophagy and Lysosomal Dysfunction Lab, Vall d'Hebron Research Institute (VHIR), Barcelona, Spain.
  7. Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, NY, USA; Institute for Aging Studies, Albert Einstein College of Medicine, NY, USA; Department of Medicine, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, NY, USA. Electronic address: [email protected].

PMID: 34563704 PMCID: PMC8616816 DOI: 10.1016/j.arr.2021.101468

Abstract

Autophagy, an essential cellular process that mediates degradation of proteins and organelles in lysosomes, has been tightly linked to cellular quality control for its role as part of the proteostasis network. The current interest in identifying the cellular and molecular determinants of aging, has highlighted the important contribution of malfunctioning of autophagy with age to the loss of proteostasis that characterizes all old organisms. However, the diversity of cellular functions of the different types of autophagy and the often reciprocal interactions of autophagy with other determinants of aging, is placing autophagy at the center of the aging process. In this work, we summarize evidence for the contribution of autophagy to health- and lifespan and provide examples of the bidirectional interplay between autophagic pathways and several of the so-called hallmarks of aging. This central role of autophagy in aging, and the dependence on autophagy of many geroprotective interventions, has motivated a search for direct modulators of autophagy that could be used to slow aging and extend healthspan. Here, we review some of those ongoing therapeutic efforts and comment on the potential of targeting autophagy in aging.

Copyright © 2021 Elsevier B.V. All rights reserved.

Keywords: Aging; Chaperones; Lysosomes; Organelle turnover; Proteolysis; Proteostasis

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