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Chaperone-Mediated Autophagy Upregulation Rescues Megalin Expression and Localization in Cystinotic Proximal Tubule Cells.

Frontiers in endocrinology

Zhang J, He J, Johnson JL, Rahman F, Gavathiotis E, Cuervo AM, Catz SD.
PMID: 30774622
Front Endocrinol (Lausanne). 2019 Feb 01;10:21. doi: 10.3389/fendo.2019.00021. eCollection 2019.

Cystinosis is a lysosomal storage disorder caused by defects in

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Zhang J, He J, Johnson JL, et al. Chaperone-Mediated Autophagy Upregulation Rescues Megalin Expression and Localization in Cystinotic Proximal Tubule Cells. Front Endocrinol (Lausanne). 2019;10:21doi: 10.3389/fendo.2019.00021.
Zhang, J., He, J., Johnson, J. L., Rahman, F., Gavathiotis, E., Cuervo, A. M., & Catz, S. D. (2019). Chaperone-Mediated Autophagy Upregulation Rescues Megalin Expression and Localization in Cystinotic Proximal Tubule Cells. Frontiers in endocrinology, 1021. https://doi.org/10.3389/fendo.2019.00021
Zhang, Jinzhong, et al. "Chaperone-Mediated Autophagy Upregulation Rescues Megalin Expression and Localization in Cystinotic Proximal Tubule Cells." Frontiers in endocrinology vol. 10 (2019): 21. doi: https://doi.org/10.3389/fendo.2019.00021
Zhang J, He J, Johnson JL, Rahman F, Gavathiotis E, Cuervo AM, Catz SD. Chaperone-Mediated Autophagy Upregulation Rescues Megalin Expression and Localization in Cystinotic Proximal Tubule Cells. Front Endocrinol (Lausanne). 2019 Feb 01;10:21. doi: 10.3389/fendo.2019.00021. eCollection 2019. PMID: 30774622; PMCID: PMC6367655.
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Reciprocal regulation of chaperone-mediated autophagy and the circadian clock.

Nature cell biology

Juste YR, Kaushik S, Bourdenx M, Aflakpui R, Bandyopadhyay S, Garcia F, Diaz A, Lindenau K, Tu V, Krause GJ, Jafari M, Singh R, Muñoz J, Macian F, Cuervo AM.
PMID: 34876687
Nat Cell Biol. 2021 Dec;23(12):1255-1270. doi: 10.1038/s41556-021-00800-z. Epub 2021 Dec 07.

Circadian rhythms align physiological functions with the light-dark cycle through oscillatory changes in the abundance of proteins in the clock transcriptional programme. Timely removal of these proteins by different proteolytic systems is essential to circadian strength and adaptability. Here...

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Juste YR, Kaushik S, Bourdenx M, et al. Reciprocal regulation of chaperone-mediated autophagy and the circadian clock. Nat Cell Biol. 2021;23(12):1255-1270doi: 10.1038/s41556-021-00800-z.
Juste, Y. R., Kaushik, S., Bourdenx, M., Aflakpui, R., Bandyopadhyay, S., Garcia, F., Diaz, A., Lindenau, K., Tu, V., Krause, G. J., Jafari, M., Singh, R., Muñoz, J., Macian, F., & Cuervo, A. M. (2021). Reciprocal regulation of chaperone-mediated autophagy and the circadian clock. Nature cell biology, 23(12), 1255-1270. https://doi.org/10.1038/s41556-021-00800-z
Juste, Yves R, et al. "Reciprocal regulation of chaperone-mediated autophagy and the circadian clock." Nature cell biology vol. 23,12 (2021): 1255-1270. doi: https://doi.org/10.1038/s41556-021-00800-z
Juste YR, Kaushik S, Bourdenx M, Aflakpui R, Bandyopadhyay S, Garcia F, Diaz A, Lindenau K, Tu V, Krause GJ, Jafari M, Singh R, Muñoz J, Macian F, Cuervo AM. Reciprocal regulation of chaperone-mediated autophagy and the circadian clock. Nat Cell Biol. 2021 Dec;23(12):1255-1270. doi: 10.1038/s41556-021-00800-z. Epub 2021 Dec 07. PMID: 34876687; PMCID: PMC8688252.
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Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome.

Cell

Bourdenx M, Martín-Segura A, Scrivo A, Rodriguez-Navarro JA, Kaushik S, Tasset I, Diaz A, Storm NJ, Xin Q, Juste YR, Stevenson E, Luengo E, Clement CC, Choi SJ, Krogan NJ, Mosharov EV, Santambrogio L, Grueninger F, Collin L, Swaney DL, Sulzer D, Gavathiotis E, Cuervo AM.
PMID: 33891876
Cell. 2021 May 13;184(10):2696-2714.e25. doi: 10.1016/j.cell.2021.03.048. Epub 2021 Apr 22.

Components of the proteostasis network malfunction in aging, and reduced protein quality control in neurons has been proposed to promote neurodegeneration. Here, we investigate the role of chaperone-mediated autophagy (CMA), a selective autophagy shown to degrade neurodegeneration-related proteins, in...

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Bourdenx M, Martín-Segura A, Scrivo A, et al. Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome. Cell. 2021;184(10):2696-2714.e25doi: 10.1016/j.cell.2021.03.048.
Bourdenx, M., Martín-Segura, A., Scrivo, A., Rodriguez-Navarro, J. A., Kaushik, S., Tasset, I., Diaz, A., Storm, N. J., Xin, Q., Juste, Y. R., Stevenson, E., Luengo, E., Clement, C. C., Choi, S. J., Krogan, N. J., Mosharov, E. V., Santambrogio, L., Grueninger, F., Collin, L., Swaney, D. L., Sulzer, D., Gavathiotis, E., & Cuervo, A. M. (2021). Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome. Cell, 184(10), 2696-2714.e25. https://doi.org/10.1016/j.cell.2021.03.048
Bourdenx, Mathieu, et al. "Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome." Cell vol. 184,10 (2021): 2696-2714.e25. doi: https://doi.org/10.1016/j.cell.2021.03.048
Bourdenx M, Martín-Segura A, Scrivo A, Rodriguez-Navarro JA, Kaushik S, Tasset I, Diaz A, Storm NJ, Xin Q, Juste YR, Stevenson E, Luengo E, Clement CC, Choi SJ, Krogan NJ, Mosharov EV, Santambrogio L, Grueninger F, Collin L, Swaney DL, Sulzer D, Gavathiotis E, Cuervo AM. Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome. Cell. 2021 May 13;184(10):2696-2714.e25. doi: 10.1016/j.cell.2021.03.048. Epub 2021 Apr 22. PMID: 33891876; PMCID: PMC8152331.
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Autophagy and the hallmarks of aging.

Ageing research reviews

Kaushik S, Tasset I, Arias E, Pampliega O, Wong E, Martinez-Vicente M, Cuervo AM.
PMID: 34563704
Ageing Res Rev. 2021 Dec;72:101468. doi: 10.1016/j.arr.2021.101468. Epub 2021 Sep 24.

Autophagy, an essential cellular process that mediates degradation of proteins and organelles in lysosomes, has been tightly linked to cellular quality control for its role as part of the proteostasis network. The current interest in identifying the cellular and...

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Kaushik S, Tasset I, Arias E, et al. Autophagy and the hallmarks of aging. Ageing Res Rev. 2021;72:101468doi: 10.1016/j.arr.2021.101468.
Kaushik, S., Tasset, I., Arias, E., Pampliega, O., Wong, E., Martinez-Vicente, M., & Cuervo, A. M. (2021). Autophagy and the hallmarks of aging. Ageing research reviews, 72101468. https://doi.org/10.1016/j.arr.2021.101468
Kaushik, Susmita, et al. "Autophagy and the hallmarks of aging." Ageing research reviews vol. 72 (2021): 101468. doi: https://doi.org/10.1016/j.arr.2021.101468
Kaushik S, Tasset I, Arias E, Pampliega O, Wong E, Martinez-Vicente M, Cuervo AM. Autophagy and the hallmarks of aging. Ageing Res Rev. 2021 Dec;72:101468. doi: 10.1016/j.arr.2021.101468. Epub 2021 Sep 24. PMID: 34563704; PMCID: PMC8616816.
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Lipophagy: connecting autophagy and lipid metabolism.

International journal of cell biology

Singh R, Cuervo AM.
PMID: 22536247
Int J Cell Biol. 2012;2012:282041. doi: 10.1155/2012/282041. Epub 2012 Mar 28.

Lipid droplets (LDs), initially considered "inert" lipid deposits, have gained during the last decade the classification of cytosolic organelles due to their defined composition and the multiplicity of specific cellular functions in which they are involved. The classification of...

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Singh R, Cuervo AM. Lipophagy: connecting autophagy and lipid metabolism. Int J Cell Biol. 2012;2012:282041doi: 10.1155/2012/282041.
Singh, R., & Cuervo, A. M. (2012). Lipophagy: connecting autophagy and lipid metabolism. International journal of cell biology, 2012282041. https://doi.org/10.1155/2012/282041
Singh, Rajat, and Cuervo, Ana Maria. "Lipophagy: connecting autophagy and lipid metabolism." International journal of cell biology vol. 2012 (2012): 282041. doi: https://doi.org/10.1155/2012/282041
Singh R, Cuervo AM. Lipophagy: connecting autophagy and lipid metabolism. Int J Cell Biol. 2012;2012:282041. doi: 10.1155/2012/282041. Epub 2012 Mar 28. PMID: 22536247; PMCID: PMC3320019.
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Reciprocal regulation of chaperone-mediated autophagy and the circadian clock.

Nature cell biology

Juste YR, Kaushik S, Bourdenx M, Aflakpui R, Bandyopadhyay S, Garcia F, Diaz A, Lindenau K, Tu V, Krause GJ, Jafari M, Singh R, Muñoz J, Macian F, Cuervo AM.
PMID: 34876687
Nat Cell Biol. 2021 Dec;23(12):1255-1270. doi: 10.1038/s41556-021-00800-z. Epub 2021 Dec 07.

Circadian rhythms align physiological functions with the light-dark cycle through oscillatory changes in the abundance of proteins in the clock transcriptional programme. Timely removal of these proteins by different proteolytic systems is essential to circadian strength and adaptability. Here...

Cite
Juste YR, Kaushik S, Bourdenx M, et al. Reciprocal regulation of chaperone-mediated autophagy and the circadian clock. Nat Cell Biol. 2021;23(12):1255-1270doi: 10.1038/s41556-021-00800-z.
Juste, Y. R., Kaushik, S., Bourdenx, M., Aflakpui, R., Bandyopadhyay, S., Garcia, F., Diaz, A., Lindenau, K., Tu, V., Krause, G. J., Jafari, M., Singh, R., Muñoz, J., Macian, F., & Cuervo, A. M. (2021). Reciprocal regulation of chaperone-mediated autophagy and the circadian clock. Nature cell biology, 23(12), 1255-1270. https://doi.org/10.1038/s41556-021-00800-z
Juste, Yves R, et al. "Reciprocal regulation of chaperone-mediated autophagy and the circadian clock." Nature cell biology vol. 23,12 (2021): 1255-1270. doi: https://doi.org/10.1038/s41556-021-00800-z
Juste YR, Kaushik S, Bourdenx M, Aflakpui R, Bandyopadhyay S, Garcia F, Diaz A, Lindenau K, Tu V, Krause GJ, Jafari M, Singh R, Muñoz J, Macian F, Cuervo AM. Reciprocal regulation of chaperone-mediated autophagy and the circadian clock. Nat Cell Biol. 2021 Dec;23(12):1255-1270. doi: 10.1038/s41556-021-00800-z. Epub 2021 Dec 07. PMID: 34876687; PMCID: PMC8688252.
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Reciprocal regulation of chaperone-mediated autophagy and the circadian clock.

Nature cell biology

Juste YR, Kaushik S, Bourdenx M, Aflakpui R, Bandyopadhyay S, Garcia F, Diaz A, Lindenau K, Tu V, Krause GJ, Jafari M, Singh R, Muñoz J, Macian F, Cuervo AM.
PMID: 34876687
Nat Cell Biol. 2021 Dec;23(12):1255-1270. doi: 10.1038/s41556-021-00800-z. Epub 2021 Dec 07.

Circadian rhythms align physiological functions with the light-dark cycle through oscillatory changes in the abundance of proteins in the clock transcriptional programme. Timely removal of these proteins by different proteolytic systems is essential to circadian strength and adaptability. Here...

Cite
Juste YR, Kaushik S, Bourdenx M, et al. Reciprocal regulation of chaperone-mediated autophagy and the circadian clock. Nat Cell Biol. 2021;23(12):1255-1270doi: 10.1038/s41556-021-00800-z.
Juste, Y. R., Kaushik, S., Bourdenx, M., Aflakpui, R., Bandyopadhyay, S., Garcia, F., Diaz, A., Lindenau, K., Tu, V., Krause, G. J., Jafari, M., Singh, R., Muñoz, J., Macian, F., & Cuervo, A. M. (2021). Reciprocal regulation of chaperone-mediated autophagy and the circadian clock. Nature cell biology, 23(12), 1255-1270. https://doi.org/10.1038/s41556-021-00800-z
Juste, Yves R, et al. "Reciprocal regulation of chaperone-mediated autophagy and the circadian clock." Nature cell biology vol. 23,12 (2021): 1255-1270. doi: https://doi.org/10.1038/s41556-021-00800-z
Juste YR, Kaushik S, Bourdenx M, Aflakpui R, Bandyopadhyay S, Garcia F, Diaz A, Lindenau K, Tu V, Krause GJ, Jafari M, Singh R, Muñoz J, Macian F, Cuervo AM. Reciprocal regulation of chaperone-mediated autophagy and the circadian clock. Nat Cell Biol. 2021 Dec;23(12):1255-1270. doi: 10.1038/s41556-021-00800-z. Epub 2021 Dec 07. PMID: 34876687.
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Geroscience in the Age of COVID-19.

Aging and disease

Barzilai N, Appleby JC, Austad SN, Cuervo AM, Kaeberlein M, Gonzalez-Billault C, Lederman S, Stambler I, Sierra F.
PMID: 32765937
Aging Dis. 2020 Jul 23;11(4):725-729. doi: 10.14336/AD.2020.0629. eCollection 2020 Jul.

The data on COVID-19 is clear on at least one point: Older adults are most vulnerable to hospitalization, disability and death following infection with the novel coronavirus. Therefore, therapeutically addressing degenerative aging processes as the main risk factors appears...

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Barzilai N, Appleby JC, Austad SN, et al. Geroscience in the Age of COVID-19. Aging Dis. 2020;11(4):725-729doi: 10.14336/AD.2020.0629.
Barzilai, N., Appleby, J. C., Austad, S. N., Cuervo, A. M., Kaeberlein, M., Gonzalez-Billault, C., Lederman, S., Stambler, I., & Sierra, F. (2020). Geroscience in the Age of COVID-19. Aging and disease, 11(4), 725-729. https://doi.org/10.14336/AD.2020.0629
Barzilai, Nir, et al. "Geroscience in the Age of COVID-19." Aging and disease vol. 11,4 (2020): 725-729. doi: https://doi.org/10.14336/AD.2020.0629
Barzilai N, Appleby JC, Austad SN, Cuervo AM, Kaeberlein M, Gonzalez-Billault C, Lederman S, Stambler I, Sierra F. Geroscience in the Age of COVID-19. Aging Dis. 2020 Jul 23;11(4):725-729. doi: 10.14336/AD.2020.0629. eCollection 2020 Jul. PMID: 32765937; PMCID: PMC7390533.
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Reciprocal regulation of chaperone-mediated autophagy and the circadian clock.

Nature cell biology

Juste YR, Kaushik S, Bourdenx M, Aflakpui R, Bandyopadhyay S, Garcia F, Diaz A, Lindenau K, Tu V, Krause GJ, Jafari M, Singh R, Muñoz J, Macian F, Cuervo AM.
PMID: 34876687
Nat Cell Biol. 2021 Dec;23(12):1255-1270. doi: 10.1038/s41556-021-00800-z. Epub 2021 Dec 07.

Circadian rhythms align physiological functions with the light-dark cycle through oscillatory changes in the abundance of proteins in the clock transcriptional programme. Timely removal of these proteins by different proteolytic systems is essential to circadian strength and adaptability. Here...

Cite
Juste YR, Kaushik S, Bourdenx M, et al. Reciprocal regulation of chaperone-mediated autophagy and the circadian clock. Nat Cell Biol. 2021;23(12):1255-1270doi: 10.1038/s41556-021-00800-z.
Juste, Y. R., Kaushik, S., Bourdenx, M., Aflakpui, R., Bandyopadhyay, S., Garcia, F., Diaz, A., Lindenau, K., Tu, V., Krause, G. J., Jafari, M., Singh, R., Muñoz, J., Macian, F., & Cuervo, A. M. (2021). Reciprocal regulation of chaperone-mediated autophagy and the circadian clock. Nature cell biology, 23(12), 1255-1270. https://doi.org/10.1038/s41556-021-00800-z
Juste, Yves R, et al. "Reciprocal regulation of chaperone-mediated autophagy and the circadian clock." Nature cell biology vol. 23,12 (2021): 1255-1270. doi: https://doi.org/10.1038/s41556-021-00800-z
Juste YR, Kaushik S, Bourdenx M, Aflakpui R, Bandyopadhyay S, Garcia F, Diaz A, Lindenau K, Tu V, Krause GJ, Jafari M, Singh R, Muñoz J, Macian F, Cuervo AM. Reciprocal regulation of chaperone-mediated autophagy and the circadian clock. Nat Cell Biol. 2021 Dec;23(12):1255-1270. doi: 10.1038/s41556-021-00800-z. Epub 2021 Dec 07. PMID: 34876687; PMCID: PMC8688252.
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Showing 1 to 9 of 9 entries