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Zhang D, Zhang F, Liu M, et al. Disease activity prediction and prognosis of anti-GBM nephritis based on T lymphocyte subset ratios. Int J Immunopathol Pharmacol. 2021;35:20587384211039391doi: 10.1177/20587384211039391.
Zhang, D., Zhang, F., Liu, M., Zhang, M., Zhang, J., & Wang, J. (2021). Disease activity prediction and prognosis of anti-GBM nephritis based on T lymphocyte subset ratios. International journal of immunopathology and pharmacology, 3520587384211039391. https://doi.org/10.1177/20587384211039391
Zhang, Dan, et al. "Disease activity prediction and prognosis of anti-GBM nephritis based on T lymphocyte subset ratios." International journal of immunopathology and pharmacology vol. 35 (2021): 20587384211039391. doi: https://doi.org/10.1177/20587384211039391
Zhang D, Zhang F, Liu M, Zhang M, Zhang J, Wang J. Disease activity prediction and prognosis of anti-GBM nephritis based on T lymphocyte subset ratios. Int J Immunopathol Pharmacol. 2021 Jan-Dec;35:20587384211039391. doi: 10.1177/20587384211039391. PMID: 34595959; PMCID: PMC8489752.
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Int J Immunopathol Pharmacol. 2021 Jan-Dec;35:20587384211039391. doi: 10.1177/20587384211039391.

Disease activity prediction and prognosis of anti-GBM nephritis based on T lymphocyte subset ratios.

International journal of immunopathology and pharmacology

Dan Zhang, Fan Zhang, Meiling Liu, Mingchao Zhang, Jiong Zhang, Jinquan Wang

Affiliations

  1. National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
  2. Department of Nephrology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
  3. Division of Life Sciences and Medicine, 117556The First Affiliated Hospital of USTC, Hefei, Anhui, China.

PMID: 34595959 PMCID: PMC8489752 DOI: 10.1177/20587384211039391

Abstract

INTRODUCTION: Cell-mediated autoimmunity, especially the autoreactivity of T cells, is known to underlie the initiation of anti-glomerular basement membrane disease. However, the T lymphocyte subsets that determine the disease activity, renal fibrosis, and prognosis of anti-GBM disease have not been clearly elucidated.

METHODS: The T lymphocyte subsets (CD4+ and CD8+) were examined on peripheral blood and renal biopsy tissues from 65 patients with biopsy proven anti-GBM disease. Patients were divided into the high ratio group and low ratio group according to the cutoff values in the receiver operating characteristic curve analysis. The correlations of T lymphocyte subsets with clinical, pathological data, and renal outcome were analyzed.

RESULTS: By the end of follow-up, 45 patients (69.2%) developed end-stage renal disease (ESRD). In peripheral blood, the CD4+/CD8+ ratio showed a predictive ability with a sensitivity and specificity of 91.3% and 52.9%, respectively, which gave rise to a cutoff value of 0.89. There was a significant difference in the activity index between these two groups (3.91 ± 1.38 vs. 2.89 ± 1.13,

CONCLUSIONS: The CD4+/CD8+ ratio was associated with renal activity index both in peripheral blood and renal tissue and predicts the renal prognosis of patients with anti-GBM nephritis.

Keywords: Anti-GBM nephritis; disease activity; immune cells; renal outcome

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