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Wang SS, Zhong C, Epeldegui M, et al. Host characteristics associated with serologic inflammatory biomarkers in women. Cytokine. 2021;149:155726doi: 10.1016/j.cyto.2021.155726.
Wang, S. S., Zhong, C., Epeldegui, M., Nunes, S., Magpantay, L., DeHart, J. C., Hurley, S., Goldberg, D., Martinez, E., Lacey, J. V., Martinez-Maza, O., & Reynolds, P. (2022). Host characteristics associated with serologic inflammatory biomarkers in women. Cytokine, 149155726. https://doi.org/10.1016/j.cyto.2021.155726
Wang, Sophia S, et al. "Host characteristics associated with serologic inflammatory biomarkers in women." Cytokine vol. 149 (2022): 155726. doi: https://doi.org/10.1016/j.cyto.2021.155726
Wang SS, Zhong C, Epeldegui M, Nunes S, Magpantay L, DeHart JC, Hurley S, Goldberg D, Martinez E, Lacey JV, Martinez-Maza O, Reynolds P. Host characteristics associated with serologic inflammatory biomarkers in women. Cytokine. 2022 Jan;149:155726. doi: 10.1016/j.cyto.2021.155726. Epub 2021 Oct 16. PMID: 34666235.
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Cytokine. 2022 Jan;149:155726. doi: 10.1016/j.cyto.2021.155726. Epub 2021 Oct 16.

Host characteristics associated with serologic inflammatory biomarkers in women.

Cytokine

Sophia S Wang, Charlie Zhong, Marta Epeldegui, Sarah Nunes, Larry Magpantay, Jessica Clague DeHart, Susan Hurley, Debbie Goldberg, Elena Martinez, James V Lacey, Otoniel Martinez-Maza, Peggy Reynolds

Affiliations

  1. Division of Health Analytics, City of Hope, Duarte, CA, USA. Electronic address: [email protected].
  2. Eugene and Ruth Roberts Academy, City of Hope, Duarte, CA, USA.
  3. University of California, Los Angeles, CA, USA.
  4. Eugene and Ruth Roberts Academy, City of Hope, Duarte, CA, USA; Chapman University, Orange, CA, USA.
  5. Claremont College, Claremont, CA, USA.
  6. University of California San Francisco, CA, USA; Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, CA, USA.
  7. University of California San Francisco, CA, USA.
  8. University of California San Diego, CA, USA.
  9. Division of Health Analytics, City of Hope, Duarte, CA, USA.

PMID: 34666235 DOI: 10.1016/j.cyto.2021.155726

Abstract

BACKGROUND: There is growing evidence that exposure to low-grade inflammation may be associated with adverse health outcomes.

METHODS: We conducted a cross-sectional study within the California Teachers Study prospective cohort, among female participants who had completed a questionnaire that asked about their health behaviors (e.g., diabetes, physical activity, body mass index, medication use) and who had donated blood within a year of their questionnaire. 822 women with stored serum were evaluated for 16 immune biomarkers. In addition, four immune pathways were constructed: Th1, pro-inflammatory/macrophage activation, B-cell activation, and T-cell activation. Odds ratios (ORs) and 95% confidence intervals (CI) for the association between host characteristics and immune biomarkers were assessed using logistic regression models.

RESULT: Compared to women of a normal BMI, obese women (>30 kg/m

CONCLUSIONS: Several host characteristics were associated with circulating levels of immune biomarkers, including markers of inflammation. Further understanding of associations between immune marker profiles with human disease are warranted.

Copyright © 2021 Elsevier Ltd. All rights reserved.

Keywords: Blood; Circulating markers; Cross-sectional; Diabetes; Epidemiology; Human; Inflammation; Obesity; Physical activity; Statins

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