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Krøigård T, Gylfadottir SS, Itani M, et al. Normative reference values for the dorsal sural nerve derived from a large multicenter cohort. Clin Neurophysiol Pract. 2021;6:239-243doi: 10.1016/j.cnp.2021.08.001.
Krøigård, T., Gylfadottir, S. S., Itani, M., Khan, K. S., Andersen, H., Sindrup, S. H., Jensen, T. S., Andersen, K. V., Tankisi, H., Beniczky, S., & Kristensen, A. G. (2021). Normative reference values for the dorsal sural nerve derived from a large multicenter cohort. Clinical neurophysiology practice, 6239-243. https://doi.org/10.1016/j.cnp.2021.08.001
Krøigård, Thomas, et al. "Normative reference values for the dorsal sural nerve derived from a large multicenter cohort." Clinical neurophysiology practice vol. 6 (2021): 239-243. doi: https://doi.org/10.1016/j.cnp.2021.08.001
Krøigård T, Gylfadottir SS, Itani M, Khan KS, Andersen H, Sindrup SH, Jensen TS, Andersen KV, Tankisi H, Beniczky S, Kristensen AG. Normative reference values for the dorsal sural nerve derived from a large multicenter cohort. Clin Neurophysiol Pract. 2021 Sep 02;6:239-243. doi: 10.1016/j.cnp.2021.08.001. eCollection 2021. PMID: 34604609; PMCID: PMC8473014.
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Clin Neurophysiol Pract. 2021 Sep 02;6:239-243. doi: 10.1016/j.cnp.2021.08.001. eCollection 2021.

Normative reference values for the dorsal sural nerve derived from a large multicenter cohort.

Clinical neurophysiology practice

Thomas Krøigård, Sandra S Gylfadottir, Mustapha Itani, Karolina S Khan, Henning Andersen, Søren H Sindrup, Troels S Jensen, Kjeld V Andersen, Hatice Tankisi, Sándor Beniczky, Alexander Gramm Kristensen

Affiliations

  1. Research Unit for Neurology, Odense University Hospital, Odense, Denmark.
  2. University of Southern Denmark, Odense, Denmark.
  3. Department of Neurology, Aarhus University Hospital, Aarhus University, Aarhus, Denmark.
  4. Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
  5. Aleris-Hamlet Hospital, Søborg, Denmark.
  6. Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus University, Aarhus, Denmark.
  7. Department of Clinical Neurophysiology, Danish Epilepsy Centre (Member of the ERN EpiCARE), Dianalund, Denmark.

PMID: 34604609 PMCID: PMC8473014 DOI: 10.1016/j.cnp.2021.08.001

Abstract

OBJECTIVES: Dorsal sural nerve conduction studies (NCS) may increase the sensitivity for the diagnosis of polyneuropathy, but clinical use is limited by a lack of reliable normative reference values in all age-groups. The aim of our study was to develop reference values for the dorsal sural nerve, based on a large multicenter cohort of healthy subjects.

METHODS: Bilateral antidromic NCS were performed using standard surface electrodes in 229 healthy subjects (aged 21-80 years; median: 54 years). We assessed the normality of data distribution for amplitudes and conduction velocity (CV) and for their logarithmic (ln) transformation. The effects of age and height were determined using linear regression analysis.

RESULTS: Sensory potentials were present in all subjects. Logarithmically transformed data were normally distributed. Age

CONCLUSIONS: Dorsal sural nerve NCS are robust and have well defined normative limits.

SIGNIFICANCE: The findings provide a basis for more sensitive NCS in clinical practice and future studies of the diagnostic accuracy of NCS in polyneuropathy.

© 2021 International Federation of Clinical Neurophysiology. Published by Elsevier B.V.

Keywords: Diagnosis; Dorsal sural nerve; Nerve conduction studies; Polyneuropathy; Reference values

Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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