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Trimmel K, Vos SB, Caciagli L, et al. Decoupling of functional and structural language networks in temporal lobe epilepsy. Epilepsia. 2021;62(12):2941-2954doi: 10.1111/epi.17098.
Trimmel, K., Vos, S. B., Caciagli, L., Xiao, F., van Graan, L. A., Winston, G. P., Koepp, M. J., Thompson, P. J., & Duncan, J. S. (2021). Decoupling of functional and structural language networks in temporal lobe epilepsy. Epilepsia, 62(12), 2941-2954. https://doi.org/10.1111/epi.17098
Trimmel, Karin, et al. "Decoupling of functional and structural language networks in temporal lobe epilepsy." Epilepsia vol. 62,12 (2021): 2941-2954. doi: https://doi.org/10.1111/epi.17098
Trimmel K, Vos SB, Caciagli L, Xiao F, van Graan LA, Winston GP, Koepp MJ, Thompson PJ, Duncan JS. Decoupling of functional and structural language networks in temporal lobe epilepsy. Epilepsia. 2021 Dec;62(12):2941-2954. doi: 10.1111/epi.17098. Epub 2021 Oct 12. PMID: 34642939.
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Epilepsia. 2021 Dec;62(12):2941-2954. doi: 10.1111/epi.17098. Epub 2021 Oct 12.

Decoupling of functional and structural language networks in temporal lobe epilepsy.

Epilepsia

Karin Trimmel, Sjoerd B Vos, Lorenzo Caciagli, Fenglai Xiao, Louis A van Graan, Gavin P Winston, Matthias J Koepp, Pamela J Thompson, John S Duncan

Affiliations

  1. Epilepsy Society MRI Unit, Epilepsy Society, Chalfont St Peter, UK.
  2. Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, Queen Square, London, UK.
  3. Department of Neurology, Medical University of Vienna, Vienna, Austria.
  4. Centre for Medical Image Computing, University College London, London, UK.
  5. Neuroradiological Academic Unit, UCL Queen Square Institute of Neurology, University College London, London, UK.
  6. Department of Neurology, West China of Sichuan University, Chengdu, China.
  7. Division of Neurology, Department of Medicine, Queen's University, Kingston, Canada.

PMID: 34642939 DOI: 10.1111/epi.17098

Abstract

OBJECTIVE: To identify functional and structural alterations in language networks of people with temporal lobe epilepsy (TLE), who frequently present with naming and word-finding difficulties.

METHODS: Fifty-five patients with unilateral TLE (29 left) and 16 controls were studied with auditory and picture naming functional magnetic resonance imaging (fMRI) tasks. Activation maxima in the left posterobasal temporal lobe were used as seed regions for whole-brain functional connectivity analyses (psychophysiological interaction). White matter language pathways were investigated using diffusion tensor imaging and neurite orientation dispersion and density imaging metrics extracted along fiber bundles starting from fMRI-guided seeds. Regression analyses were performed to investigate the correlation of functional connectivity with diffusion MRI metrics.

RESULTS: In the whole group of patients and controls, weaker functional connectivity from the left posterobasal temporal lobe (1) to the bilateral anterior temporal lobe, precentral gyrus, and lingual gyrus during auditory naming and (2) to the bilateral occipital cortex and right fusiform gyrus during picture naming was associated with decreased neurite orientation dispersion and higher free water fraction of white matter tracts. Compared to controls, TLE patients exhibited fewer structural connections and an impaired coupling of functional and structural metrics.

SIGNIFICANCE: TLE is associated with an impairment and decoupling of functional and structural language networks. White matter damage, as evidenced by diffusion abnormalities, may contribute to impaired functional connectivity and language dysfunction in TLE.

© 2021 The Authors. Epilepsia published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.

Keywords: DTI; NODDI; diffusion MRI; functional connectivity; language network; naming function; temporal lobe epilepsy

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