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Psihogios AM, Rabbi M, Ahmed A, et al. Understanding Adolescent and Young Adult 6-Mercaptopurine Adherence and mHealth Engagement During Cancer Treatment: Protocol for Ecological Momentary Assessment. JMIR Res Protoc. 2021;10(10):e32789doi: 10.2196/32789.
Psihogios, A. M., Rabbi, M., Ahmed, A., McKelvey, E. R., Li, Y., Laurenceau, J. P., Hunger, S. P., Fleisher, L., Pai, A. L., Schwartz, L. A., Murphy, S. A., & Barakat, L. P. (2021). Understanding Adolescent and Young Adult 6-Mercaptopurine Adherence and mHealth Engagement During Cancer Treatment: Protocol for Ecological Momentary Assessment. JMIR research protocols, 10(10), e32789. https://doi.org/10.2196/32789
Psihogios, Alexandra M, et al. "Understanding Adolescent and Young Adult 6-Mercaptopurine Adherence and mHealth Engagement During Cancer Treatment: Protocol for Ecological Momentary Assessment." JMIR research protocols vol. 10,10 (2021): e32789. doi: https://doi.org/10.2196/32789
Psihogios AM, Rabbi M, Ahmed A, McKelvey ER, Li Y, Laurenceau JP, Hunger SP, Fleisher L, Pai AL, Schwartz LA, Murphy SA, Barakat LP. Understanding Adolescent and Young Adult 6-Mercaptopurine Adherence and mHealth Engagement During Cancer Treatment: Protocol for Ecological Momentary Assessment. JMIR Res Protoc. 2021 Oct 22;10(10):e32789. doi: 10.2196/32789. PMID: 34677129; PMCID: PMC8571686.
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JMIR Res Protoc. 2021 Oct 22;10(10):e32789. doi: 10.2196/32789.

Understanding Adolescent and Young Adult 6-Mercaptopurine Adherence and mHealth Engagement During Cancer Treatment: Protocol for Ecological Momentary Assessment.

JMIR research protocols

Alexandra M Psihogios, Mashfiqui Rabbi, Annisa Ahmed, Elise R McKelvey, Yimei Li, Jean-Philippe Laurenceau, Stephen P Hunger, Linda Fleisher, Ahna Lh Pai, Lisa A Schwartz, Susan A Murphy, Lamia P Barakat

Affiliations

  1. Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, United States.
  2. Department of Statistics, Harvard University, Boston, MA, United States.
  3. Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
  4. Children's Hospital of Philadelphia, La Salle University, Philadelphia, PA, United States.
  5. Department of Psychology, University of Delaware, Newark, DE, United States.
  6. Health Communications and Health Disparities, Fox Chase Cancer Center, Philadelphia, PA, United States.
  7. Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, United States.

PMID: 34677129 PMCID: PMC8571686 DOI: 10.2196/32789

Abstract

BACKGROUND: Adolescents and young adults (AYAs) with cancer demonstrate suboptimal oral chemotherapy adherence, increasing their risk of cancer relapse. It is unclear how everyday time-varying contextual factors (eg, mood) affect their adherence, stalling the development of personalized mobile health (mHealth) interventions. Poor engagement is also a challenge across mHealth trials; an effective adherence intervention must be engaging to promote uptake.

OBJECTIVE: This protocol aims to determine the temporal associations between daily contextual factors and 6-mercaptopurine (6-MP) adherence and explore the proximal impact of various engagement strategies on ecological momentary assessment survey completion.

METHODS: At the Children's Hospital of Philadelphia, AYAs with acute lymphoblastic leukemia or lymphoma who are prescribed prolonged maintenance chemotherapy that includes daily oral 6-MP are eligible, along with their matched caregivers. Participants will use an ecological momentary assessment app called ADAPTS (Adherence Assessments and Personalized Timely Support)-a version of an open-source app that was modified for AYAs with cancer through a user-centered process-and complete surveys in bursts over 6 months. Theory-informed engagement strategies will be microrandomized to estimate the causal effects on proximal survey completion.

RESULTS: With funding from the National Cancer Institute and institutional review board approval, of the proposed 30 AYA-caregiver dyads, 60% (18/30) have been enrolled; of the 18 enrolled, 15 (83%) have completed the study so far.

CONCLUSIONS: This protocol represents an important first step toward prescreening tailoring variables and engagement components for a just-in-time adaptive intervention designed to promote both 6-MP adherence and mHealth engagement.

INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/32789.

©Alexandra M Psihogios, Mashfiqui Rabbi, Annisa Ahmed, Elise R McKelvey, Yimei Li, Jean-Philippe Laurenceau, Stephen P Hunger, Linda Fleisher, Ahna LH Pai, Lisa A Schwartz, Susan A Murphy, Lamia P Barakat. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 22.10.2021.

Keywords: adolescents; cancer; ecological momentary assessment; mHealth; mobile phone; oncology; self-management; young adults

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