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Rosero Salazar DH, van Rheden REM, van Hulzen M, et al. Fibrin with Laminin-Nidogen Reduces Fibrosis and Improves Soft Palate Regeneration Following Palatal Injury. Biomolecules. 2021;11(10)doi: 10.3390/biom11101547.
Rosero Salazar, D. H., van Rheden, R. E. M., van Hulzen, M., Carvajal Monroy, P. L., Wagener, F. A. D. T. G., & Von den Hoff, J. W. (2021). Fibrin with Laminin-Nidogen Reduces Fibrosis and Improves Soft Palate Regeneration Following Palatal Injury. Biomolecules, 11(10), . https://doi.org/10.3390/biom11101547
Rosero Salazar, Doris H, et al. "Fibrin with Laminin-Nidogen Reduces Fibrosis and Improves Soft Palate Regeneration Following Palatal Injury." Biomolecules vol. 11,10 (2021). doi: https://doi.org/10.3390/biom11101547
Rosero Salazar DH, van Rheden REM, van Hulzen M, Carvajal Monroy PL, Wagener FADTG, Von den Hoff JW. Fibrin with Laminin-Nidogen Reduces Fibrosis and Improves Soft Palate Regeneration Following Palatal Injury. Biomolecules. 2021 Oct 19;11(10). doi: 10.3390/biom11101547. PMID: 34680180; PMCID: PMC8533998.
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Biomolecules. 2021 Oct 19;11(10). doi: 10.3390/biom11101547.

Fibrin with Laminin-Nidogen Reduces Fibrosis and Improves Soft Palate Regeneration Following Palatal Injury.

Biomolecules

Doris H Rosero Salazar, René E M van Rheden, Manon van Hulzen, Paola L Carvajal Monroy, Frank A D T G Wagener, Johannes W Von den Hoff

Affiliations

  1. Department of Dentistry, Orthodontics and Craniofacial Biology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, 6525EX Nijmegen, The Netherlands.
  2. Department of Medical Basic Sciences, Faculty of Health, Universidad Icesi, Cali 760008, Colombia.
  3. Central Facility for Research with Laboratory Animals (CDL), Radboud University Medical Centre, 6525EZ Nijmegen, The Netherlands.
  4. Department of Oral and Maxillofacial Surgery, Special Dental Care and Orthodontics, Erasmus Medical Center, 3015GD Rotterdam, The Netherlands.

PMID: 34680180 PMCID: PMC8533998 DOI: 10.3390/biom11101547

Abstract

This study aimed to analyze the effects of fibrin constructs enhanced with laminin-nidogen, implanted in the wounded rat soft palate. Fibrin constructs with and without laminin-nidogen were implanted in 1 mm excisional wounds in the soft palate of 9-week-old rats and compared with the wounded soft palate without implantation. Collagen deposition and myofiber formation were analyzed at days 3, 7, 28 and 56 after wounding by histochemistry. In addition, immune staining was performed for a-smooth muscle actin (a-SMA), myosin heavy chain (MyHC) and paired homeobox protein 7 (Pax7). At day 56, collagen areas were smaller in both implant groups (31.25 ± 7.73% fibrin only and 21.11 ± 6.06% fibrin with laminin-nidogen)) compared to the empty wounds (38.25 ± 8.89%,

Keywords: cleft palate; fibrin; nidogen; regenerative medicine; skeletal muscle; soft palate

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