Display options
Cite
Chen S, Chen L, Ye L, et al. PP2A-mTOR-p70S6K/4E-BP1 axis regulates M1 polarization of pulmonary macrophages and promotes ambient particulate matter induced mouse lung injury. J Hazard Mater. 2021;424:127624doi: 10.1016/j.jhazmat.2021.127624.
Chen, S., Chen, L., Ye, L., Jiang, Y., Li, Q., Zhang, H., Zhang, R., Li, H., Yu, D., Zhang, R., Niu, Y., Zhao, Q., Liu, J., Ouyang, G., Aschner, M., Zheng, Y., Zhang, L., Chen, W., & Li, D. (2021). PP2A-mTOR-p70S6K/4E-BP1 axis regulates M1 polarization of pulmonary macrophages and promotes ambient particulate matter induced mouse lung injury. Journal of hazardous materials, 424127624. https://doi.org/10.1016/j.jhazmat.2021.127624
Chen, Shen, et al. "PP2A-mTOR-p70S6K/4E-BP1 axis regulates M1 polarization of pulmonary macrophages and promotes ambient particulate matter induced mouse lung injury." Journal of hazardous materials vol. 424 (2021): 127624. doi: https://doi.org/10.1016/j.jhazmat.2021.127624
Chen S, Chen L, Ye L, Jiang Y, Li Q, Zhang H, Zhang R, Li H, Yu D, Zhang R, Niu Y, Zhao Q, Liu J, Ouyang G, Aschner M, Zheng Y, Zhang L, Chen W, Li D. PP2A-mTOR-p70S6K/4E-BP1 axis regulates M1 polarization of pulmonary macrophages and promotes ambient particulate matter induced mouse lung injury. J Hazard Mater. 2021 Oct 29;424:127624. doi: 10.1016/j.jhazmat.2021.127624. Epub 2021 Oct 29. PMID: 34740159.
Copy Download .nbib Format: NLM
Share it on

J Hazard Mater. 2021 Oct 29;424:127624. doi: 10.1016/j.jhazmat.2021.127624. Epub 2021 Oct 29.

PP2A-mTOR-p70S6K/4E-BP1 axis regulates M1 polarization of pulmonary macrophages and promotes ambient particulate matter induced mouse lung injury.

Journal of hazardous materials

Shen Chen, Liping Chen, Lizhu Ye, Yue Jiang, Qiong Li, Haiyan Zhang, Rui Zhang, Huiyao Li, Dianke Yu, Rong Zhang, Yujie Niu, Qun Zhao, Jianhui Liu, Gangfeng Ouyang, Michael Aschner, Yuxin Zheng, Lihua Zhang, Wen Chen, Daochuan Li

Affiliations

  1. Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
  2. Department of Toxicology, School of Public Health, Qingdao University, Qingdao 266021, China.
  3. Department of Toxicology, School of Public Health, Hebei Medical University, Shijiazhuang 050017, China.
  4. Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Science, National Chromatographic Research and Analysis Center, Dalian 116023, China.
  5. KLGHEI of Environment and Energy Chemistry, School of Chemistry, Sun Yat-sen University, Guangzhou 510275, Guangdong, China.
  6. Department of Molecular Pharmacology, Albert Einstein College of Medicine, Forchheimer 209, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
  7. Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. Electronic address: [email protected].
  8. Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. Electronic address: [email protected].

PMID: 34740159 DOI: 10.1016/j.jhazmat.2021.127624

Abstract

To identify key signaling pathways involved in ambient particulate matter (PM)-induced pulmonary injury, we generated a mouse model with myeloid-specific deletion of Ppp2r1a gene (encoding protein phosphatase 2 A (PP2A) A subunit), and conducted experiments in a real-ambient PM exposure system. PP2A Aα

Copyright © 2021 Elsevier B.V. All rights reserved.

Keywords: Inflammatory response; MTOR-p70S6K/4E-BP1 signaling pathway; Macrophage polarization; Particulate matter; Protein phosphatase 2A

Publication Types