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Farrell SW, Leonard D, Shuval K, et al. Cardiorespiratory fitness, white blood cell count, and mortality in men and women. J Sport Health Sci. 2021;doi: 10.1016/j.jshs.2021.10.005.
Farrell, S. W., Leonard, D., Shuval, K., DeFina, L. F., Barlow, C. E., Pavlovic, A., & Haskell, W. L. (2021). Cardiorespiratory fitness, white blood cell count, and mortality in men and women. Journal of sport and health science, . https://doi.org/10.1016/j.jshs.2021.10.005
Farrell, Stephen W, et al. "Cardiorespiratory fitness, white blood cell count, and mortality in men and women." Journal of sport and health science vol. (2021). doi: https://doi.org/10.1016/j.jshs.2021.10.005
Farrell SW, Leonard D, Shuval K, DeFina LF, Barlow CE, Pavlovic A, Haskell WL. Cardiorespiratory fitness, white blood cell count, and mortality in men and women. J Sport Health Sci. 2021 Nov 03; doi: 10.1016/j.jshs.2021.10.005. Epub 2021 Nov 03. PMID: 34740872.
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J Sport Health Sci. 2021 Nov 03; doi: 10.1016/j.jshs.2021.10.005. Epub 2021 Nov 03.

Cardiorespiratory fitness, white blood cell count, and mortality in men and women.

Journal of sport and health science

Stephen W Farrell, David Leonard, Kerem Shuval, Laura F DeFina, Carolyn E Barlow, Andjelka Pavlovic, William L Haskell

Affiliations

  1. Research Division, The Cooper Institute, Dallas, TX 75230, USA. Electronic address: [email protected].
  2. Research Division, The Cooper Institute, Dallas, TX 75230, USA.
  3. Department of Medicine, Stanford University, Palo Alto, CA 94305, USA.

PMID: 34740872 DOI: 10.1016/j.jshs.2021.10.005

Abstract

BACKGROUND: We examined the associations of cardiorespiratory fitness (CRF) and white blood cell count (WBC) with mortality outcomes.

METHODS: A total of 52,056 apparently healthy adults completed a comprehensive health examination, including a maximal treadmill test and blood chemistry analyses. CRF was categorized as high, moderate, or low by age and sex; WBC was categorized as sex-specific quartiles.

RESULTS: During 17.8 ± 9.5 years (mean ± SD) of follow-up, a total of 4088 deaths occurred. When regressed jointly, significantly decreased all-cause mortality across CRF categories was observed within each quartile of WBC in men. Within WBC Quartile 1, all-cause mortality hazard ratios (HRs) with a 95% confidence interval (95%CI) were 1.0 (referent), 1.29 (95%CI: 1.06‒1.57), and 2.03 (95%CI: 1.42‒2.91) for high, moderate, and low CRF categories, respectively (p trend < 0.001). Similar trends were observed in the remaining 3 quartiles. With the exception of cardiovascular disease (CVD) mortality within Quartile 1 (p trend = 0.74), there were also similar trends across CRF categories within WBC quartiles in men for both CVD and cancer mortality (p trend < 0.01 for all). For women, there were no significant trends across CRF categories for mortality outcomes within Quartiles 1-3. However, we observed significantly decreased all-cause mortality across CRF categories within WBC Quartile 4 (HR = 1.05 (0.76‒1.44), 1.63 (1.20‒2.21), and 1.87 (1.29‒2.69) for high, moderate, and low CRF, respectively (p trend = 0.002)). Similar trends in women were observed for CVD and cancer mortality within WBC Quartile 4 only.

CONCLUSION: There are strong joint associations between CRF, WBC, and all-cause, CVD, and cancer mortality in men; these associations are less consistent in women.

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Keywords: Complete blood count; Epidemiology; Inflammation; Physical fitness

Conflict of interest statement

Competing interests The authors declare that they have no competing interests.

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