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Sammallahti S, Holmlund-Suila E, Zou R, et al. Prenatal maternal and cord blood vitamin D concentrations and negative affectivity in infancy. Eur Child Adolesc Psychiatry. 2021;doi: 10.1007/s00787-021-01894-4.
Sammallahti, S., Holmlund-Suila, E., Zou, R., Valkama, S., Rosendahl, J., Enlund-Cerullo, M., Hauta-Alus, H., Lahti-Pulkkinen, M., El Marroun, H., Tiemeier, H., Mäkitie, O., Andersson, S., Räikkönen, K., & Heinonen, K. (2021). Prenatal maternal and cord blood vitamin D concentrations and negative affectivity in infancy. European child & adolescent psychiatry, . https://doi.org/10.1007/s00787-021-01894-4
Sammallahti, Sara, et al. "Prenatal maternal and cord blood vitamin D concentrations and negative affectivity in infancy." European child & adolescent psychiatry vol. (2021). doi: https://doi.org/10.1007/s00787-021-01894-4
Sammallahti S, Holmlund-Suila E, Zou R, Valkama S, Rosendahl J, Enlund-Cerullo M, Hauta-Alus H, Lahti-Pulkkinen M, El Marroun H, Tiemeier H, Mäkitie O, Andersson S, Räikkönen K, Heinonen K. Prenatal maternal and cord blood vitamin D concentrations and negative affectivity in infancy. Eur Child Adolesc Psychiatry. 2021 Oct 18; doi: 10.1007/s00787-021-01894-4. Epub 2021 Oct 18. PMID: 34657965.
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Eur Child Adolesc Psychiatry. 2021 Oct 18; doi: 10.1007/s00787-021-01894-4. Epub 2021 Oct 18.

Prenatal maternal and cord blood vitamin D concentrations and negative affectivity in infancy.

European child & adolescent psychiatry

Sara Sammallahti, Elisa Holmlund-Suila, Runyu Zou, Saara Valkama, Jenni Rosendahl, Maria Enlund-Cerullo, Helena Hauta-Alus, Marius Lahti-Pulkkinen, Hanan El Marroun, Henning Tiemeier, Outi Mäkitie, Sture Andersson, Katri Räikkönen, Kati Heinonen

Affiliations

  1. Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC, Sophia Children's Hospital, Rotterdam, The Netherlands.
  2. Department of Social and Behavioral Science, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  3. Pediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  4. Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  5. Folkhälsan Research Center, Helsinki, Finland.
  6. National Institute for Health and Welfare (THL), Helsinki, Finland.
  7. PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.
  8. Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  9. Department of Psychology, Education and Child Studies, Erasmus School of Social and Behavioural Sciences, Erasmus University Rotterdam, Rotterdam, The Netherlands.
  10. Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland. [email protected].
  11. Psychology/Welfare Sciences, Faculty of Social Sciences, Tampere University, 33014, Tampere, Finland. [email protected].

PMID: 34657965 DOI: 10.1007/s00787-021-01894-4

Abstract

Higher maternal vitamin D concentration during pregnancy is associated with better child mental health. Negative affectivity, an early-emerging temperamental trait, indicates an increased risk of psychopathology. We investigated if maternal early/mid-pregnancy 25-hydroxyvitamin D (25(OH)D) and neonatal cord blood 25(OH)D concentrations are associated with Negative affectivity in infancy. We studied term-born infants from the vitamin D Intervention in Infants study (VIDI, n = 777, follow-up rate 80%, Finland), and the Generation R Study (n = 1505, follow-up rate 40%, Netherlands). We measured maternal serum 25(OH)D at 6-27 weeks (VIDI) or 18-25 weeks (Generation R) of pregnancy, and cord blood 25(OH)D at birth (both cohorts). Caregivers rated infant Negative affectivity at 11.7 months (VIDI) or 6.5 months (Generation R) using the Revised Infant Behavior Questionnaire. Using linear regression, we tested associations between 25(OH)D and Negative affectivity adjusted for infant age, sex, season of 25(OH)D measurement, maternal age, education, smoking, and body-mass-index. Per 10 nmol/l increase in maternal early/mid-pregnancy 25(OH)D, infant Negative affectivity decreased by 0.02 standard deviations (95% confidence interval [CI] - 0.06, - 0.004) in VIDI, and 0.03 standard deviations (95% CI - 0.03, - 0.01) in Generation R. Cord blood 25(OH)D was associated with Negative affectivity in Generation R (- 0.03, 95% CI - 0.05, - 0.01), but not VIDI (0.00, 95% CI - 0.02, 0.02). Lower maternal 25(OH)D concentrations were consistently associated with higher infant Negative affectivity, while associations between cord blood 25(OH)D concentrations and Negative affectivity were less clear. Maternal vitamin D status during early- and mid-pregnancy may be linked with early-emerging differences in offspring behavior.

© 2021. The Author(s).

Keywords: Infant mental health; Negative affectivity; Nutrition; Prenatal; Temperament; Vitamin D

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