Display options
Cite
Alatise OI, Knapp GC, Sharma A, et al. Molecular and phenotypic profiling of colorectal cancer patients in West Africa reveals biological insights. Nat Commun. 2021;12(1):6821doi: 10.1038/s41467-021-27106-w.
Alatise, O. I., Knapp, G. C., Sharma, A., Chatila, W. K., Arowolo, O. A., Olasehinde, O., Famurewa, O. C., Omisore, A. D., Komolafe, A. O., Olaofe, O. O., Katung, A. I., Ibikunle, D. E., Egberongbe, A. A., Olatoke, S. A., Agodirin, S. O., Adesiyun, O. A., Adeyeye, A., Kolawole, O. A., Olakanmi, A. O., Arora, K., Constable, J., Shah, R., Basunia, A., Sylvester, B., Wu, C., Weiser, M. R., Seier, K., Gonen, M., Stadler, Z. K., Kemel, Y., Vakiani, E., Berger, M. F., Chan, T. A., Solit, D. B., Shia, J., Sanchez-Vega, F., Schultz, N., Brennan, M., Smith, J. J., & Kingham, T. P. (2021). Molecular and phenotypic profiling of colorectal cancer patients in West Africa reveals biological insights. Nature communications, 12(1), 6821. https://doi.org/10.1038/s41467-021-27106-w
Alatise, Olusegun Isaac, et al. "Molecular and phenotypic profiling of colorectal cancer patients in West Africa reveals biological insights." Nature communications vol. 12,1 (2021): 6821. doi: https://doi.org/10.1038/s41467-021-27106-w
Alatise OI, Knapp GC, Sharma A, Chatila WK, Arowolo OA, Olasehinde O, Famurewa OC, Omisore AD, Komolafe AO, Olaofe OO, Katung AI, Ibikunle DE, Egberongbe AA, Olatoke SA, Agodirin SO, Adesiyun OA, Adeyeye A, Kolawole OA, Olakanmi AO, Arora K, Constable J, Shah R, Basunia A, Sylvester B, Wu C, Weiser MR, Seier K, Gonen M, Stadler ZK, Kemel Y, Vakiani E, Berger MF, Chan TA, Solit DB, Shia J, Sanchez-Vega F, Schultz N, Brennan M, Smith JJ, Kingham TP. Molecular and phenotypic profiling of colorectal cancer patients in West Africa reveals biological insights. Nat Commun. 2021 Nov 24;12(1):6821. doi: 10.1038/s41467-021-27106-w. PMID: 34819518; PMCID: PMC8613248.
Copy Download .nbib Format: NLM
Share it on

Nat Commun. 2021 Nov 24;12(1):6821. doi: 10.1038/s41467-021-27106-w.

Molecular and phenotypic profiling of colorectal cancer patients in West Africa reveals biological insights.

Nature communications

Olusegun Isaac Alatise, Gregory C Knapp, Avinash Sharma, Walid K Chatila, Olukayode A Arowolo, Olalekan Olasehinde, Olusola C Famurewa, Adeleye D Omisore, Akinwumi O Komolafe, Olaejinrinde O Olaofe, Aba I Katung, David E Ibikunle, Adedeji A Egberongbe, Samuel A Olatoke, Sulaiman O Agodirin, Olusola A Adesiyun, Ademola Adeyeye, Oladapo A Kolawole, Akinwumi O Olakanmi, Kanika Arora, Jeremy Constable, Ronak Shah, Azfar Basunia, Brooke Sylvester, Chao Wu, Martin R Weiser, Ken Seier, Mithat Gonen, Zsofia K Stadler, Yelena Kemel, Efsevia Vakiani, Michael F Berger, Timothy A Chan, David B Solit, Jinru Shia, Francisco Sanchez-Vega, Nikolaus Schultz, Murray Brennan, J Joshua Smith, T Peter Kingham

Affiliations

  1. Faculty of Clinical Sciences, College of Health Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria.
  2. Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  3. Division of General Surgery, Department of Surgery, Dalhousie University, Halifax, NS, Canada.
  4. Marie-Jose and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  5. Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  6. Tri-Institutional Program in Computational Biology and Medicine, Weill Cornell Medical College, New York, NY, USA.
  7. Federal Medical Centre, Owo, Ondo State, Nigeria.
  8. Department of Surgery, University of Ilorin Teaching Hospital, Ilorin, Nigeria.
  9. Department of Surgery, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.
  10. Department of Surgery, University of Medical Sciences, Ondo, Ondo State, Nigeria.
  11. Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  12. Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  13. Clinical Genetics Service and the Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  14. Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  15. Niehaus Center for Inherited Cancer Genomics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  16. Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  17. Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  18. Bobst International Center, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  19. Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA. [email protected].

PMID: 34819518 PMCID: PMC8613248 DOI: 10.1038/s41467-021-27106-w

Abstract

Understanding the molecular and phenotypic profile of colorectal cancer (CRC) in West Africa is vital to addressing the regions rising burden of disease. Tissue from unselected Nigerian patients was analyzed with a multigene, next-generation sequencing assay. The rate of microsatellite instability is significantly higher among Nigerian CRC patients (28.1%) than patients from The Cancer Genome Atlas (TCGA, 14.2%) and Memorial Sloan Kettering Cancer Center (MSKCC, 8.5%, P < 0.001). In microsatellite-stable cases, tumors from Nigerian patients are less likely to have APC mutations (39.1% vs. 76.0% MSKCC P < 0.001) and WNT pathway alterations (47.8% vs. 81.9% MSKCC, P < 0.001); whereas RAS pathway alteration is more prevalent (76.1% vs. 59.6%, P = 0.03). Nigerian CRC patients are also younger and more likely to present with rectal disease (50.8% vs. 33.7% MSKCC, P < 0.001). The findings suggest a unique biology of CRC in Nigeria, which emphasizes the need for regional data to guide diagnostic and treatment approaches for patients in West Africa.

© 2021. The Author(s).

References

  1. BMC Med Genomics. 2017 May 19;10(1):33 - PubMed
  2. Anticancer Res. 2017 May;37(5):2649-2654 - PubMed
  3. Nat Med. 2017 Jun;23(6):703-713 - PubMed
  4. JCO Precis Oncol. 2017;2017: - PubMed
  5. J Glob Oncol. 2019 Feb;5:1-22 - PubMed
  6. J Clin Oncol. 2008 Dec 10;26(35):5783-8 - PubMed
  7. Cancer Cell. 2018 Jan 8;33(1):125-136.e3 - PubMed
  8. Science. 2017 Jul 28;357(6349):409-413 - PubMed
  9. Niger Postgrad Med J. 2009 Mar;16(1):35-9 - PubMed
  10. Niger Med J. 2017 May-Jun;58(3):87-91 - PubMed
  11. Nat Commun. 2018 Jun 12;9(1):2287 - PubMed
  12. Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6870-5 - PubMed
  13. Surgery. 2014 Aug;156(2):305-10 - PubMed
  14. West Afr J Med. 2012 Jul-Sep;31(3):198-203 - PubMed
  15. J Clin Oncol. 2016 Jun 20;34(18):2141-7 - PubMed
  16. JCO Precis Oncol. 2017 Jul;2017: - PubMed
  17. Clin Gastroenterol Hepatol. 2008 Feb;6(2):206-14 - PubMed
  18. Lancet. 2010 Mar 20;375(9719):1030-47 - PubMed
  19. Genet Med. 2015 May;17(5):405-24 - PubMed
  20. Niger J Clin Pract. 2011 Oct-Dec;14(4):432-5 - PubMed
  21. Nat Rev Gastroenterol Hepatol. 2019 Dec;16(12):713-732 - PubMed
  22. J Glob Health. 2012 Dec;2(2):020404 - PubMed
  23. Genome Biol. 2014 Feb 03;15(2):R22 - PubMed
  24. Eur J Cancer Care (Engl). 2009 Mar;18(2):110-5 - PubMed
  25. Nature. 2012 Jul 18;487(7407):330-7 - PubMed
  26. Clin Cancer Res. 2014 Sep 15;20(18):4962-70 - PubMed
  27. Cell. 2018 Apr 5;173(2):321-337.e10 - PubMed
  28. Best Pract Res Clin Gastroenterol. 2010 Aug;24(4):381-96 - PubMed
  29. Bioinformatics. 2014 Apr 1;30(7):1015-6 - PubMed
  30. Gastroenterology. 2014 Dec;147(6):1308-1316.e1 - PubMed
  31. J Mol Diagn. 2015 May;17(3):251-64 - PubMed

Publication Types

Grant support