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Zu Y, Yang J, Zhang C, et al. The Pathological Mechanisms of Estrogen-Induced Cholestasis: Current Perspectives. Front Pharmacol. 2021;12:761255doi: 10.3389/fphar.2021.761255.
Zu, Y., Yang, J., Zhang, C., & Liu, D. (2021). The Pathological Mechanisms of Estrogen-Induced Cholestasis: Current Perspectives. Frontiers in pharmacology, 12761255. https://doi.org/10.3389/fphar.2021.761255
Zu, Yue, et al. "The Pathological Mechanisms of Estrogen-Induced Cholestasis: Current Perspectives." Frontiers in pharmacology vol. 12 (2021): 761255. doi: https://doi.org/10.3389/fphar.2021.761255
Zu Y, Yang J, Zhang C, Liu D. The Pathological Mechanisms of Estrogen-Induced Cholestasis: Current Perspectives. Front Pharmacol. 2021 Nov 08;12:761255. doi: 10.3389/fphar.2021.761255. eCollection 2021. PMID: 34819862; PMCID: PMC8606790.
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Front Pharmacol. 2021 Nov 08;12:761255. doi: 10.3389/fphar.2021.761255. eCollection 2021.

The Pathological Mechanisms of Estrogen-Induced Cholestasis: Current Perspectives.

Frontiers in pharmacology

Yue Zu, Jinyu Yang, Chengliang Zhang, Dong Liu

Affiliations

  1. Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

PMID: 34819862 PMCID: PMC8606790 DOI: 10.3389/fphar.2021.761255

Abstract

Estrogens are steroid hormones with a wide range of biological activities. The excess of estrogens can lead to decreased bile flow, toxic bile acid (BA) accumulation, subsequently causing intrahepatic cholestasis. Estrogen-induced cholestasis (EIC) may have increased incidence during pregnancy, and within women taking oral contraception and postmenopausal hormone replacement therapy, and result in liver injury, preterm birth, meconium-stained amniotic fluid, and intrauterine fetal death in pregnant women. The main pathogenic mechanisms of EIC may include deregulation of BA synthetic or metabolic enzymes, and BA transporters. In addition, impaired cell membrane fluidity, inflammatory responses and change of hepatocyte tight junctions are also involved in the pathogenesis of EIC. In this article, we review the role of estrogens in intrahepatic cholestasis, and outlined the mechanisms of EIC, providing a greater understanding of this disease.

Copyright © 2021 Zu, Yang, Zhang and Liu.

Keywords: bile acid homeostasis; estrogens; inflammation; intrahepatic cholestasis; membrane fluidity; transporter

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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