Display options
Cite
Matsuoka K, Akaihata H, Hata J, et al. l-Theanine Protects Bladder Function by Suppressing Chronic Sympathetic Hyperactivity in Spontaneously Hypertensive Rat. Metabolites. 2021;11(11)doi: 10.3390/metabo11110778.
Matsuoka, K., Akaihata, H., Hata, J., Tanji, R., Honda-Takinami, R., Onagi, A., Hoshi, S., Koguchi, T., Sato, Y., Kataoka, M., Ogawa, S., & Kojima, Y. (2021). l-Theanine Protects Bladder Function by Suppressing Chronic Sympathetic Hyperactivity in Spontaneously Hypertensive Rat. Metabolites, 11(11), . https://doi.org/10.3390/metabo11110778
Matsuoka, Kanako, et al. "l-Theanine Protects Bladder Function by Suppressing Chronic Sympathetic Hyperactivity in Spontaneously Hypertensive Rat." Metabolites vol. 11,11 (2021). doi: https://doi.org/10.3390/metabo11110778
Matsuoka K, Akaihata H, Hata J, Tanji R, Honda-Takinami R, Onagi A, Hoshi S, Koguchi T, Sato Y, Kataoka M, Ogawa S, Kojima Y. l-Theanine Protects Bladder Function by Suppressing Chronic Sympathetic Hyperactivity in Spontaneously Hypertensive Rat. Metabolites. 2021 Nov 14;11(11). doi: 10.3390/metabo11110778. PMID: 34822436; PMCID: PMC8618158.
Copy Download .nbib Format: NLM
Share it on

Metabolites. 2021 Nov 14;11(11). doi: 10.3390/metabo11110778.

l-Theanine Protects Bladder Function by Suppressing Chronic Sympathetic Hyperactivity in Spontaneously Hypertensive Rat.

Metabolites

Kanako Matsuoka, Hidenori Akaihata, Junya Hata, Ryo Tanji, Ruriko Honda-Takinami, Akifumi Onagi, Seiji Hoshi, Tomoyuki Koguchi, Yuichi Sato, Masao Kataoka, Soichiro Ogawa, Yoshiyuki Kojima

Affiliations

  1. Department of Urology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960-1295, Japan.

PMID: 34822436 PMCID: PMC8618158 DOI: 10.3390/metabo11110778

Abstract

Chronic sympathetic hyperactivity is known to affect metabolism and cause various organ damage including bladder dysfunction. In this study, we evaluated whether l-theanine, a major amino acid found in green tea, ameliorates bladder dysfunction induced by chronic sympathetic hyperactivity as a dietary component for daily consumption. Spontaneously hypertensive rats (SHRs), as an animal model of bladder dysfunction, were divided into SHR-water and SHR-theanine groups. After 6 weeks of oral administration, the sympathetic nervous system, bladder function, and oxidative stress of bladder tissue were evaluated. The mean blood pressure, serum noradrenaline level, and media-to-lumen ratio of small arteries in the suburothelium were significantly lower in the SHR-theanine than in the SHR-water group. Micturition interval was significantly longer, and bladder capacity was significantly higher in the SHR-theanine than in the SHR-water group. Bladder strip contractility was also higher in the SHR-theanine than in the SHR-water group. Western blotting of bladder showed that expression of malondialdehyde was significantly lower in the SHR-theanine than in the SHR-water group. These results suggested that orally administered l-theanine may contribute at least partly to the prevention of bladder dysfunctions by inhibiting chronic sympathetic hyperactivity and protecting bladder contractility.

Keywords: bladder dysfunction; chronic sympathetic hyperactivity; l-theanine; oral administration; prevention

References

  1. Life Sci. 1988;43(13):1063-8 - PubMed
  2. Neurourol Urodyn. 2012 Mar;31(3):293-9 - PubMed
  3. Int J Urol. 2020 Mar;27(3):258-265 - PubMed
  4. Biosci Biotechnol Biochem. 1999 Apr;63(4):615-8 - PubMed
  5. Psychopharmacology (Berl). 2018 Jan;235(1):37-45 - PubMed
  6. Neurourol Urodyn. 2013 Apr;32(4):393-8 - PubMed
  7. Hokkaido Igaku Zasshi. 1982 Sep;57(5):55-6 - PubMed
  8. Eur J Cancer Prev. 2011 May;20(3):157-65 - PubMed
  9. Gynecol Obstet Invest. 2018;83(2):140-144 - PubMed
  10. J Physiol Anthropol. 2012 Oct 29;31:28 - PubMed
  11. J Nat Med. 2014 Oct;68(4):699-708 - PubMed
  12. Urology. 2018 Jan;111:238.e7-238.e12 - PubMed
  13. J Biol Eng. 2018 Jan 8;12:1 - PubMed
  14. Neurourol Urodyn. 2014 Jan;33(1):54-8 - PubMed
  15. Physiol Genomics. 2013 Jul 2;45(13):528-38 - PubMed
  16. Urol J. 2019 Aug 18;16(4):371-374 - PubMed
  17. Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H1-7 - PubMed
  18. Pharmacol Biochem Behav. 2020 Feb;189:172842 - PubMed
  19. Neurourol Urodyn. 2012 Jun;31(5):695-701 - PubMed
  20. Neurourol Urodyn. 2014 Mar;33(3):350-7 - PubMed
  21. Circ Res. 2015 Mar 13;116(6):1007-21 - PubMed
  22. J Urol. 2013 Feb;189(2):754-61 - PubMed
  23. J Hypertens. 2014 Feb;32(2):216-24 - PubMed
  24. Biol Psychol. 2008 Feb;77(2):113-22 - PubMed
  25. Nutr Hosp. 2014 Mar 01;29(3):479-90 - PubMed
  26. Biosci Biotechnol Biochem. 1995 Apr;59(4):615-8 - PubMed
  27. J Pharmacol Exp Ther. 1990 Feb;252(2):706-10 - PubMed
  28. Arh Hig Rada Toksikol. 2011 Jun;62(2):139-46 - PubMed
  29. Hypertension. 1992 May;19(5):425-7 - PubMed
  30. J Hypertens. 1995 Mar;13(3):341-7 - PubMed
  31. Asia Pac J Clin Nutr. 2008;17 Suppl 1:167-8 - PubMed
  32. Sci Rep. 2020 Nov 16;10(1):19844 - PubMed
  33. Am J Physiol. 1998 Oct;275(4):R1366-73 - PubMed
  34. Pharmacol Biochem Behav. 2013 Oct;111:128-35 - PubMed
  35. Brain Res. 1998 Apr 20;790(1-2):151-9 - PubMed
  36. Jpn Circ J. 1963 Mar;27:282-93 - PubMed
  37. Eur Child Adolesc Psychiatry. 2021 Feb 26;: - PubMed

Publication Types